The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients

Validity of adiponectin-to-leptin and adiponectin-to-resistin ratios as predictors of polycystic ovary syndrome

“…In agreement with our results, lower adiponectin levels were seen in women with PCOS apparently independent of BMI and IR (18,35). On the other hand, leptin serum levels were higher in unselected women with PCOS compared with controls (36,37), and in obese women with PCOS and BMImatched controls compared with lean women with PCOS (11,12). It should be noted that although the waist-hip ratio was comparable between the women with PCOS and the control women, an assessment of the percentage of body fat visceral adiposity component was not performed, thus prompting the conclusion that the results may not necessarily reflect changes in body fat deposits or adiposity, which cannot be controlled for by BMI.…”

Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome

“…In contrast, adiponectin gene expression did not differ between obese and non-obese subgroups (Lecke et al 2011a(Lecke et al , 2013b. These data are in agreement with other reports regarding PCOS and control populations (Wang et al 2012). Tan et al (2006a) showed an increase in both adiponectin receptors -1 and 2 -in …”

“…These results suggest that hyperandrogenism and hyperinsulinemia may be involved in the molecular mechanisms that activate aromatase mRNA transcription in abdominal fat tissue in PCOS. Wang et al (2012) also inferred that an imbalanced androgen/ estrogen ratio and altered progesterone levels may occur in SC fat, and that this disturbance could impact the normal function of adipose tissue. Their data showed significant abnormalities in enzyme gene expression in SC adipose tissue: mRNA of enzymes synthesizing testosterone and inactivating dihydrotestosterone (DHT) and progesterone was increased in PCOS vs matched controls (Wang et al 2012).…”

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

“…It still remains controversial whether serum leptin levels are different in PCOS compared with control subjects, as shown in Table 1. Increased serum leptin concentrations have been observed in women with PCOS in comparison to weight-matched controls in certain studies (Brzechffa et al 1996, Vicennati et al 1998, El Orabi et al 1999, Brannian & Hansen 2002, Pehlivanov & Mitkov 2009, Yildizhan et al 2011). Wang et al (2012a also reported significantly higher mRNA expression of leptin in subcutaneous adipose tissue of PCOS patients compared with controls.…”