“…Moreover, comparison of expressed cDNAs has identified HMG-1(Y) as one of a number of genes upregulated in metastatic neoplasms as compared with primary cancers in both animals [29,31] and human [31,51]. In surgical specimens of human cancers, HMG-1(Y) expression is upregulated in neoplastic tissues compared with pathologically normal tissue in colorectal [32][33][34][35], prostate [28,53], thyroid [42,43,55], pancreatic [39,40], and cervical [36] carcinoma, with most studies reporting a correlation with the more aggressive phenotypes. There is some evidence associating HMG-1(Y) expression with breast [24,51], neuroblastic [37], and gastric [44] carcinomas, but the numbers of patients studied are very small.…”