The expression of the novel CYP2W1 enzyme is an independent prognostic factor in colorectal cancer – A pilot study

KRT13, FAIM2 and CYP2W1 mRNA Expression in Oral Squamous Cell Carcinoma Patients with Risk Habits

“…Comparatively at 30 months after first diagnosis, OSCC patients' overall survival seems to be better at 90% and 75% among those with up-regulation of FAIM2 and CYP2W1 expressions respectively. While the reason for these may be unknown, the finding by Edler et al (2009) seems to be in contrast with the current study. In his study, he found that 64% of colorectal cancer expressed low level of CYP2W1 expression and 36% expressed high level of CYP2W1expression and they concluded that its expression can be used as independent prognostic factor for survival, where a high expression was associated with a worse clinical outcome.…”

“…In his study, he found that 64% of colorectal cancer expressed low level of CYP2W1 expression and 36% expressed high level of CYP2W1expression and they concluded that its expression can be used as independent prognostic factor for survival, where a high expression was associated with a worse clinical outcome. It is possible that the difference in sample size in the study (n=162) by Edler et al (2009) from the current study (n=41) as one of the factors influencing the current study result.…”

“…Meanwhile, other studies showed CYP2W1 over-expression in gastric cancer (50.0%), colon cancer (78.0%) and adrenal tumour (75.0%) compared to normal tissue (Aung et al, 2006;Karlgren et al, 2006). An immunohistochemical study in colorectal cancer showed that CYP2W1 expression was associated with tumour staging and patients with higher CYP2W1 expression had worse clinical outcome in 5 and 10 year survival (Edler et al, 2009;Stenstedt et al, 2012). While most of the samples in this study showed down-regulation of CYP2W1, it could probably be due to different type of tumour and heterogeneity of the tumour itself.…”

CYP2S1 and CYP2W1 Mediate 2-(3,4-Dimethoxyphenyl)-5-Fluorobenzothiazole (GW-610, NSC 721648) Sensitivity in Breast and Colorectal Cancer Cells

“…Edler and colleagues reported that 36% CRCs expressed high CYP2W1 protein levels, which correlated with worse clinical outcome (P ¼ 0.007; ref. 13). Thus, expression of CYP2W1 is an independent prognostic factor in patients with stage II or stage III CRC.…”

Genetic and Epigenetic Factors Affecting Cytochrome P450 Phenotype and Their Clinical Relevance

“…CYP2W1 is expressed at relatively low levels (mRNA) in the human adult non-transformed tissues whereas the expression in colorectal cancer tissues was significantly higher (both at mRNA and protein levels) (Li et al, 2009;Edler et al, 2009). CYP2W1 gene expression appears to be governed by gene methylation.…”