The expression of Toll-like receptors in patients with acute myeloid leukemia treated with induction chemotherapy

Rybka, Justyna; Butrym, Aleksandra; Wróbel, Tomasz; Jaźwiec, Bożena; Stefanko, Ewa; Dobrzyńska, Olga; Poręba, Rafał; Kuliczkowski, Kazimierz

doi:10.1016/j.leukres.2015.01.002

Cited by 32 publications

(37 citation statements)

References 20 publications

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“…Our findings were similar to those of previous studies [8,20,21] which evaluated the quantitative expression of TLRs in patients with newly diagnosed or relapsed AML and concluded that the highest level of TLR expression was seen for TLR-7 while there was no significant difference in the expression of the other TLRs compared to the healthy volunteers. Similarly, other studies [6,22,23] demonstrated that the level of TLR-7/β-actin mRNA expression was significantly elevated in AML patients compared to normal cases (P < 0.05). Meanwhile there was no statistically significant difference between the level of TLR-9/β-actin mRNA expression in AML patients and in normal cases (P > 0.05).…”

Section: Discussionsupporting

confidence: 61%

Quantitative Expression of Toll-Like Receptors TLR-7 and TLR-9 on Peripheral Blood Mononuclear Cells in Leukemias

Morsi¹,

Gharabawy²,

Hamed³

et al. 2016

J Hematol

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Background: Toll-like receptors (TLRs) are agents of innate and adaptive immunity, involved in tumor activation. The expression and functionality of TLR on leukemic cells have seldom been investigated. The aims of the study were to throw some light on the quantitative expression of TLR-7 and TLR-9 on leukemic cells and to compare it with their expression on mononuclear cells of healthy volunteers.

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Section: Discussionsupporting

confidence: 61%

Quantitative Expression of Toll-Like Receptors TLR-7 and TLR-9 on Peripheral Blood Mononuclear Cells in Leukemias

Morsi¹,

Gharabawy²,

Hamed³

et al. 2016

J Hematol

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“…Finally, we identified five genes (ESR1, CD44, TLR9, DRD4, and MPO) associated with differentially methylated regions that are independent predictors of prognosis in patients with AML. 47 The expression of myeloperoxidase (MPO), a microbicidal protein, is a definitive marker for the diagnosis of AML. It plays important roles in bone growth, bone mass maintenance, and bone loss prevention.…”

Section: Discussionmentioning

confidence: 99%

Developing DNA methylation‐based prognostic biomarkers of acute myeloid leukemia

Gao

Zhuang

Zhou

et al. 2018

J of Cellular Biochemistry

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Acute myeloid leukemia (AML) is a heterogeneous clonal neoplasm characterized by complex genomic alterations. The incidence of AML increases with age, and most cases experience serious illness and poor prognosis. To explore the relationship between abnormal DNA methylation and the occurrence and development of AML based on the Gene Expression Database (GEO), this study extracted data related to methylation in AML and identified a methylated CpG site that was significantly different in terms of expression and distribution between the primary cells of AML patients, and hematopoietic stem/progenitor cells from normal bone marrow. To further investigate the differences caused by the dysfunction of methylation sites, bioinformatics analysis was used to screen methylation-related biomarkers, and the potential prognostic genes were selected by univariate and multivariate Cox proportional hazards regressions. Finally, five independent prognostic indicators were identified. In addition, these results provide new insight into the molecular mechanisms of methylation.

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“…Of note, expression of these both TLRs was reported by Rybka et al . (, ) as factors associated with the risk of sepsis and the outcome of induction therapy. Nevertheless, further genetic studies are indispensable to confirm the role of expression and polymorphisms of these two TLRs in development of infectious complications in patients with AML.…”

Section: Discussionmentioning

confidence: 99%

“…IL17F ) may be associated with AML susceptibility (Wróbel et al ., ). It was also found that TLR2 and TLR4 could act as risk factors for the development of sepsis and response to therapy in patients with AML (Rybka et al ., , ). The present study aimed to assess the effect of the polymorphisms in genes in the inflammatory pathways involved in regulation of the NF‐κB pathway ( TLR2 , TLR4 , TLR9 , TRAF3 and NFkB1 ) and susceptibility to AML and progression of the disease.…”

Section: Introductionmentioning

confidence: 99%

Variations in genes involved in regulation of the nuclear factor – κB pathway and the risk of acute myeloid leukaemia

Rybka

Gębura

Wróbel

et al. 2016

Int J Immunogenetics

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Genes involved in regulation of the nuclear factor - kappa B (NF-κB) pathway are suggested to play a role in the pathogenesis of acute myeloid leukaemia (AML). The present study aimed to assess the association between the NF-κB1, TRAF3 and TLRs genes single nucleotide polymorphisms (SNPs) and disease susceptibility as well as progression in patients with AML. For this purpose 62 patients and 126 healthy individuals were genotyped for NF-κB1 (rs28362491), TRAF3 (rs11160707; rs12147254), TLR2 (rs201786064), TLR4 (rs4986790; rs4986791) and TLR9 (rs5743836; rs187084) alleles. Three SNPs were found to be associated with the risk for the AML development. The TRAF3 (rs12147254) AA homozygosity (RR = 2.770, P = 0.0392), TLR9 (rs5743836) C wild-type allele (RR = 2.542, P = 0.0096) as well as TLR9 (rs187084) T allele (RR = 13.396, P < 0.0001) and its homozygosity (RR = 11.805, P < 0.0001) were more frequent among patients with AML than healthy individuals. The associations of the rs187084 SNP were significant for both sexes. Moreover, patients who relapsed were more frequently characterized with the presence of the rs187084 TLR9 TT genotype (P = 0.045) or the rs12147254 TRAF3 A variant (P = 0.066). In conclusion, polymorphisms within the TLR9 and TRAF3 genes are associated with predisposition to AML and may affect the progression of the disease in the Polish population.

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The expression of Toll-like receptors in patients with acute myeloid leukemia treated with induction chemotherapy

Cited by 32 publications

References 20 publications

Quantitative Expression of Toll-Like Receptors TLR-7 and TLR-9 on Peripheral Blood Mononuclear Cells in Leukemias

Quantitative Expression of Toll-Like Receptors TLR-7 and TLR-9 on Peripheral Blood Mononuclear Cells in Leukemias

Developing DNA methylation‐based prognostic biomarkers of acute myeloid leukemia

Variations in genes involved in regulation of the nuclear factor – κB pathway and the risk of acute myeloid leukaemia

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