The Expression of VEGF-A in Maxillary Mucosal Tissue of Mucormycosis Infection on Dental Extraction after Hyperbaric Oxygen Therapy

Abstract

Objective: Mucormycosis is a rare invasive fungal infection, but fatal when it occurs and triggered by tooth extraction, cause damage of the oral mucosa gingival tissue. The aim of this study is to analyze the expression of VEGF-A in maxillary mucosal tissue of mucormycosis infection on dental extraction after Hyperbaric Oxygen (HBO) therapy. Material and methods: It was a true laboratory experimental study with post test only control group design, using 34 male marmots with mean age of 3-4 month and body weight 300-400 gram and were divided in 6 groups by random allocation : 1 control group, 1 group of dental extraction and 4 intervention group. Two group, first with injection of 10 6 CFU/ml Rhizopus oryzae strain CBS 110.17 0,3 ml , and then tooh extraction. The other two group, dental extraction first and then rhizopus oryzae injection. The four intervention group were divided with non HBO and HBO treatment of 2,4 ATA 3x30 minute, one session, for 5 days. The expression of VEGF-A was examined by immunochemistry.