The extended scope of neuroimaging and prospects in brain atrophy mitigation: A systematic review

Sungura, R; Onyambu, CK; Mpolya, Emmanuel; Sauli, Elingarami; Vianney, J-M

doi:10.1016/j.inat.2020.100875

Cited by 3 publications

(4 citation statements)

References 175 publications

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“…Brain atrophy is considered a physiologic process in aging, however, infections, nutritional deficiency, metabolic and endocrine causes, trauma, drugs, and neurodegenerative diseases are among pathological causes which should be monitored and prevented [ 8 ]. Clinical manifestations of cognitive impairment, dementia, depression, gait, and visual disturbance are among the symptoms which imply brain atrophy [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Clinical manifestations of cognitive impairment, dementia, depression, gait, and visual disturbance are among the symptoms which imply brain atrophy [9]. Neuro-imaging (CT scan, and magnetic resonance imaging [MRI]) can be served as an invaluable diagnostic tool to monitor and detect brain atrophy commonly as ventricular dilation and sulci widening [8,10]. This study investigated the morphologic alterations of a normal brain through aging including ventricular changes, and cortical atrophy to provide reliable criteria for age-related degenerative changes in the brain.…”

Section: Discussionmentioning

confidence: 99%

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In search of subcortical and cortical morphologic alterations of a normal brain through aging: an investigation by computed tomography scan

Ghorbanlou,

Moradi,

Kazemi-Galougahi

et al. 2023

Anat Cell Biol

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Morphologic changes in the brain through aging, as a physiologic process, may involve a wide range of variables including ventricular dilation, and sulcus widening. This study reports normal ranges of these changes as standard criteria. Normal brain computed tomography scans of 400 patients (200 males, 200 females) in every decade of life (20 groups each containing 20 participants) were investigated for subcortical/cortical atrophy (bicaudate width [BCW], third ventricle width [ThVW], maximum length of lateral ventricle at cella media [MLCM], bicaudate index [BCI], third ventricle index [ThVI], and cella media index 3 [CMI3], interhemispheric sulcus width [IHSW], right hemisphere sulci diameter [RHSD], and left hemisphere sulci diameter [LHSD]), ventricular symmetry. Distribution and correlation of all the variables were demonstrated with age and a multiple linear regression model was reported for age prediction. Among the various parameters of subcortical atrophy, BCW, ThVW, MLCM, and the corresponding indices of BCI, ThVI, and CMI3 demonstrated a significant correlation with age (R 2 ≥0.62). All the cortical atrophy parameters including IHSW, RHSD, and LHSD demonstrated a significant correlation with age (R 2 ≥0.63). This study is a thorough investigation of variables in a normal brain which can be affected by aging disclosing normal ranges of variables including major ventricular variables, derived ventricular indices, lateral ventricles asymmetry, cortical atrophy, in every decade of life introducing BW, ThVW, MLCM, BCI, ThVI, CMI3 as most significant ventricular parameters, and IHSW, RHSD, LHSD as significant cortical parameters associated with age.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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In search of subcortical and cortical morphologic alterations of a normal brain through aging: an investigation by computed tomography scan

Ghorbanlou,

Moradi,

Kazemi-Galougahi

et al. 2023

Anat Cell Biol

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“…One theory for the maintenance of language function in light of age-related brain atrophy is the engagement of compensatory brain networks (Park and Reuter-Lorenz, 2009 ). The impact of age-related atrophy on various cognitive domains is well-documented (Raz and Rodrigue, 2006 ; Ferreira et al, 2014 ; Lowe et al, 2019 ; Sungura et al, 2020 ). Hence, investigating how compensatory mechanisms in specific cognitive domains (e.g., language) counteract the onslaught of aging may articulate ways to improve everyday functioning of older adults.…”

Section: Introductionmentioning

confidence: 99%

Functional Connectivity and Compensation of Phonemic Fluency in Aging

Mohanty

Gonzalez-Burgos

Díaz‐Flores

et al. 2021

Front. Aging Neurosci.

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Neural compensatory mechanisms associated with broad cognitive abilities have been studied. However, those associated with specific cognitive subdomains (e.g., verbal fluency) remain to be investigated in healthy aging. Here, we delineate: (a) neural substrates of verbal (phonemic) fluency, and (b) compensatory mechanisms mediating the association between these neural substrates and phonemic fluency. We analyzed resting-state functional magnetic resonance imaging from 133 right-handed, cognitively normal individuals who underwent the Controlled Oral Word Association Test (COWAT) to record their phonemic fluency. We evaluated functional connectivity in an established and extended language network comprising Wernicke, Broca, thalamic and anti-correlated modules. (a) We conducted voxel-wise multiple linear regression to identify the brain areas associated with phonemic fluency. (b) We used mediation effects of cognitive reserve, measured by the Wechsler Adult Intelligence Scale—Information subtest, upon the association between functional connectivity and phonemic fluency tested to investigate compensation. We found that: (a) Greater functional connectivity between the Wernicke module and brain areas within the anti-correlated module was associated with better performance in phonemic fluency, (b) Cognitive reserve was an unlikely mediator in younger adults. In contrast, cognitive reserve was a partial mediator of the association between functional connectivity and phonemic fluency in older adults, likely representing compensation to counter the effect of aging. We conclude that in healthy aging, higher performance in phonemic fluency at older ages could be attributed to greater functional connectivity partially facilitated by higher cognitive reserve, presumably reflecting compensatory mechanisms to minimize the effect of aging.

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Sex differences in cortical thickness and diffusion properties in patients with traumatic brain injury: a pilot study

et al. 2022

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The extended scope of neuroimaging and prospects in brain atrophy mitigation: A systematic review

Cited by 3 publications

References 175 publications

In search of subcortical and cortical morphologic alterations of a normal brain through aging: an investigation by computed tomography scan

In search of subcortical and cortical morphologic alterations of a normal brain through aging: an investigation by computed tomography scan

Functional Connectivity and Compensation of Phonemic Fluency in Aging

Sex differences in cortical thickness and diffusion properties in patients with traumatic brain injury: a pilot study

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