The extent of aortic lymphadenectomy in locally advanced cervical cancer impacts on survival

Llueca, Antoni; Escrig-Sos, Javier; Benito, Virginia; Hernández, Alicia; Díaz-Feijoó, Berta

doi:10.3802/jgo.2021.32.e4

Cited by 5 publications

(3 citation statements)

References 30 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Authors found positive PALNs in 119 women. Skip metastasis in the supramesenteric region was found in 18% of lymph nodes retrieved, without the presence of a metastases inframesenteric region [17]. According to these studies, we concluded that the LRV should be considered as the ventral limit of PALND for patients with cervical cancer and suspected PALNs' metastases.…”

Section: Boundaries Of Palnd In Gynecological Malignanciesmentioning

confidence: 80%

Section: Boundaries Of Palnd In Gynecological Malignanciesmentioning

confidence: 92%

“…Additionally, the presence of skip metastases should also be considered. [17]. Llueca et al observed 394 patients with locally advanced cancer of the uterine cervix.…”

Section: Boundaries Of Palnd In Gynecological Malignanciesmentioning

confidence: 99%

See 2 more Smart Citations

Paraaortic Lymphadenectomy in Gynecologic Oncology—Significance of Vessels Variations

Kostov

Selçuk

Yordanov

et al. 2022

JCM

View full text Add to dashboard Cite

Lymphadenectomy has been an essential part of the surgical treatment in surgical oncology, as the lymphatic channels and nodes are the main dissemination pathway for most of the gynecological cancers. Pelvic and paraaortic lymphadenectomy are frequent surgical procedures in gynecologic oncology. Paraaortic lymph node dissection facilitates staging, prognosis, surgical and postoperative management of patients. It is one of the most challenging retroperitoneal surgeries. A comprehensive knowledge of the paraaortic region is mandatory. Intraoperative bleeding is the most common complication during lymphadenectomy due to direct vascular injury, poor tissue handling, exuberant retraction and possible anatomical variations of the vessels in the paraaortic region. Approximately, one-third of women will have at least one anatomic variation in the paraaortic region. It must be stressed that anomalous vessels may be encountered in every woman who will undergo surgery. Consequently, detailed knowledge of anatomical vessels variations is required in order to prevent iatrogenic vessel injury. The importance of these variations is well described in urology, vascular and general surgery. Conversely, in oncogynecological surgery, there are few articles, which described some of the vessels variations in the paraaortic region. The present article aims to propose a surgical classification and to describe the majority of vessels variation, which could be encountered during paraaortic lymphadenectomy in gynecologic oncology. Moreover, surgical considerations in order to prevent anomalous vessels injury are well described.

show abstract

Section: Boundaries Of Palnd In Gynecological Malignanciesmentioning

confidence: 80%

Section: Boundaries Of Palnd In Gynecological Malignanciesmentioning

confidence: 92%

See 1 more Smart Citation

Paraaortic Lymphadenectomy in Gynecologic Oncology—Significance of Vessels Variations

Kostov

Selçuk

Yordanov

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

Nodal staging score: A tool to quantify the number of lymph nodes for examination and predict survival in IB–IIA cervical cancer

Qiu,

Hu,

Huang

et al. 2024

Medicine Advances

View full text Add to dashboard Cite

BackgroundAccording to current official guidelines, there is no generally recommended minimum number of lymph nodes examined during surgery for cervical cancer. However, patients with few nodes removed are still common, and the prevalence of nodal invasion may be underestimated because of false‐negative findings. In this article, we introduced a statistical tool called the Nodal Staging Score (NSS), which predicts the minimum number of examined lymph nodes to confidently ensure a node‐negative status preoperatively.MethodsUsing the beta‐binomial model, we analyzed lymph node invasion data for 8789 patients with cervical cancer from the Surveillance, Epidemiology, and End Results database. This analysis quantified the number of lymph nodes that require assessment across various early International Federation of Gynecology and Obstetrics (FIGO) stages. We also performed univariate and multivariate Cox regression analyses to explore the prognostic significance of NSS.ResultsWith an increased number of examined lymph nodes, the probability of missing nodal disease decreased and varied among different FIGO stages. For stages IB1–IIA, the examination of 6, 21, and 33 lymph nodes, respectively, was required to reduce the probability of missing positive nodes (i.e., 1−NSS) to less than 10%. The clinical significance of NSS was verified with prognostic information. Compared with NSS <0.90, NSS ≥0.90 was significantly associated with better overall survival for node‐negative patients.ConclusionThe NSS is an auxiliary tool that not only enhances the precision of FIGO staging but also provides a statistical basis for postoperative evaluation to inform further clinical decision‐making.

show abstract

Transperitoneal versus extraperitoneal laparoscopic aortic lymph nodal staging for locally advanced cervical cancer: A systematic review and meta-analysis

Capozzi¹,

Sozzi

Monfardini³

et al. 2021

European Journal of Surgical Oncology

View full text Add to dashboard Cite

The extent of aortic lymphadenectomy in locally advanced cervical cancer impacts on survival

Cited by 5 publications

References 30 publications

Paraaortic Lymphadenectomy in Gynecologic Oncology—Significance of Vessels Variations

Paraaortic Lymphadenectomy in Gynecologic Oncology—Significance of Vessels Variations

Nodal staging score: A tool to quantify the number of lymph nodes for examination and predict survival in IB–IIA cervical cancer

Transperitoneal versus extraperitoneal laparoscopic aortic lymph nodal staging for locally advanced cervical cancer: A systematic review and meta-analysis

Contact Info

Product

Resources

About