The extracts of Dracaena cochinchinensis stemwood suppress inflammatory response and phagocytosis in lipopolysaccharide-activated microglial cells

Ospondpant, Dusadee; Xia, Yingjie; Lai, Queenie Wing Sze; Yuen, Gary Ka-Wing; Yang, Meixia; Chanthanam, Kanlayakorn; Dong, Tina Tingxia; Tsim, Karl Wah Keung

doi:10.1016/j.phymed.2023.154936

Cited by 3 publications

(6 citation statements)

References 19 publications

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“…Previous findings have demonstrated that the ethanol extract of DCS exhibited a higher yield and greater pharmacological activities, as compared to the water extract ( Ospondpant et al, 2022 ; Ospondpant et al, 2023 ). To develop a promising BHP of DCS and AEF, various ratios of DCS and AEF ethanol extracts were conducted to determine the optimal level of synergism.…”

Section: Resultsmentioning

confidence: 89%

“…In this study, we have examined the potential synergistic interactions of two botanical drugs in a specific ratio deriving from BHP of nine botanical drugs. Having previous studies of the multifunctional roles of DCS in neuroprotection and anti-inflammation ( Ospondpant et al, 2022 ; Ospondpant et al, 2023 ), BHP of DCS with eight other botanical drugs was investigated. Firstly, our findings revealed that BHP of DCS and AEF at 1:1 w/w ratio demonstrated an optimal enhancement of activities in promoting neuronal differentiation and reducing Aβ fibril formation.…”

Section: Discussionmentioning

confidence: 99%

“…DCS:AEF (1:9) acts as an anti-inflammatory agent, reducing the expression of the proinflammatory molecules and promoting morphological changes in activated microglia to a resting stage. Previous study has reported that DCS could suppress the production of proinflammatory molecules through the phosphorylations of c-Jun N-terminal kinase (JNK), p38, and Akt in BV2 microglia, as well as decrease excessive phagocytosis of Aβ fibrils ( Ospondpant et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

“…S.C. Chen stemwood (DCS), known as Lakkachan or Chan Deang in Thai, has been used in Thai traditional medicine as a remedy for pyretic and inflammatory conditions ( Bureau of Drug and Narcotic, 2021 ). Previous studies have demonstrated that DCS possesses multifunctional properties, including inhibition of Aβ aggregation, protection against Aβ fibril-induced cell death, promotion of neuronal differentiation, and suppression of neuroinflammation ( Ospondpant et al, 2022 ; Ospondpant et al, 2023 ). In the Royal Medical Book of King Rama V (ตำราเวชศาสตร์ฉบับหลวง รัชกาลที่ ๕), volume II, in the section of Sabba-Lakkhana Sabba-Guna Scripture, on page 376, lines 11-13, there is a mention of a traditional formula composed of nine botanical drugs, including DCS.…”

Section: Introductionmentioning

confidence: 99%

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Synergy of botanical drug extracts from Dracaena cochinchinensis stemwood and Ardisia elliptica fruit in multifunctional effects on neuroprotection and anti-inflammation

Ospondpant,

Lai,

Dong

et al. 2024

Front. Pharmacol.

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Combination therapy is one of the promising approaches in developing therapeutics to cure complex diseases, such as Alzheimer’s disease (AD). In Thai traditional medicines, the clinical application often comprises multiple botanical drugs as a formulation. The synergistic interactions between botanical drugs in combination therapies are proposed to have several advantages, including increased therapeutic efficacy, and decreased toxicity and/or adverse effects. This study aimed to explore the therapeutic functions of a botanical hybrid preparation (BHP) of two botanical drugs within a traditional multi-herbal formulation. The synergistic actions of BHP of Dracaena cochinchinensis stemwood (DCS) and Ardisia elliptica fruit (AEF) at a specific ratio of 1:9 w/w were illustrated in neuroprotection and anti-inflammation. In cultured PC12 cells, BHP of DCS and AEF showed synergistic functions in inducing neuronal differentiation, characterized by neurofilament expression and neurite outgrowth. In addition, BHP of DCS and AEF exhibited a synergistic effect in inhibiting the aggregation of Aβ, a hallmark of AD pathology. The activated BV2 microglial cells induced by LPS were synergistically suppressed by the BHP of DCS and AEF, as evaluated by the expression of pro-inflammatory markers, including TNF-α, IL-1β, and iNOS, as well as the morphological change of microglial cells. The findings suggested that the effects of BHP of DCS and AEF were greater than individual botanical drugs in a specific ratio of 1:9 w/w to enhance neuroprotective and anti-inflammatory functions.

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Section: Resultsmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synergy of botanical drug extracts from Dracaena cochinchinensis stemwood and Ardisia elliptica fruit in multifunctional effects on neuroprotection and anti-inflammation

Ospondpant,

Lai,

Dong

et al. 2024

Front. Pharmacol.

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“…In LPS-activated microglia, D. cochinchinensis stemwood extract reduced the neuroinflammatory response by reducing pro-inflammatory factors and inhibiting the activation of p38, JNK, and Akt and by reducing the gene expressions of IL-1β, TNF-α, and iNOS. Additionally, D. cochinchinensis stemwood extract could decrease excessive phagocytosis of beads and Aβ fibrils in activated microglia ( Ospondpant et al, 2023 ). Dracaena cochinchinensis stemwood extract can also prevent the formation of Aβ fibrils, protecting against Aβ-mediated cell damage and stimulating neural differentiation ( Ospondpant et al, 2022 ).…”

Section: Neurodegenerative Diseases Involving Microglia (M1/m2) Pathwaymentioning

confidence: 99%

The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases

Darwish,

Elbadry,

Elbokhomy

et al. 2023

Front. Aging

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The pathophysiology of different neurodegenerative illnesses is significantly influenced by the polarization regulation of microglia and macrophages. Traditional classifications of macrophage phenotypes include the pro-inflammatory M1 and the anti-inflammatory M2 phenotypes. Numerous studies demonstrated dynamic non-coding RNA modifications, which are catalyzed by microglia-induced neuroinflammation. Different nutraceuticals focus on the polarization of M1/M2 phenotypes of microglia and macrophages, offering a potent defense against neurodegeneration. Caeminaxin A, curcumin, aromatic-turmerone, myricetin, aurantiamide, 3,6′-disinapoylsucrose, and resveratrol reduced M1 microglial inflammatory markers while increased M2 indicators in Alzheimer’s disease. Amyloid beta-induced microglial M1 activation was suppressed by andrographolide, sulforaphane, triptolide, xanthoceraside, piperlongumine, and novel plant extracts which also prevented microglia-mediated necroptosis and apoptosis. Asarone, galangin, baicalein, and a-mangostin reduced oxidative stress and pro-inflammatory cytokines, such as interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha in M1-activated microglia in Parkinson’s disease. Additionally, myrcene, icariin, and tenuigenin prevented the nod-like receptor family pyrin domain-containing 3 inflammasome and microglial neurotoxicity, while a-cyperone, citronellol, nobiletin, and taurine prevented NADPH oxidase 2 and nuclear factor kappa B activation. Furthermore, other nutraceuticals like plantamajoside, swertiamarin, urolithin A, kurarinone, Daphne genkwa flower, and Boswellia serrata extracts showed promising neuroprotection in treating Parkinson’s disease. In Huntington’s disease, elderberry, curcumin, iresine celosia, Schisandra chinensis, gintonin, and pomiferin showed promising results against microglial activation and improved patient symptoms. Meanwhile, linolenic acid, resveratrol, Huperzia serrata, icariin, and baicalein protected against activated macrophages and microglia in experimental autoimmune encephalomyelitis and multiple sclerosis. Additionally, emodin, esters of gallic and rosmarinic acids, Agathisflavone, and sinomenine offered promising multiple sclerosis treatments. This review highlights the therapeutic potential of using nutraceuticals to treat neurodegenerative diseases involving microglial-related pathways.

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Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

Liu,

Li,

Liang

et al. 2024

Front. Pharmacol.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory loss and cognitive impairment. It severely affects the quality of life of victims. The prevalence of AD has been increasing in recent years. Therefore, it is of great importance to elucidate the pathogenic mechanism of AD and search for effective therapeutic approaches. Gut microbiota dysbiosis, an altered state of gut microbiota, has been well known for its involvement in the pathogenesis of AD. Much effort has been made in searching for approaches capable of modulating the composition of gut microbiota in recent years. Herbal medicines have attracted extensive attention in recent decades for the prevention and treatment of AD. Here, we gave an overview of the recent research progress on the modulatory effects of herbal medicines and herbal formulae on gut microbiota as well as the possible beneficial effects on AD, which may provide new insights into the discovery of anti-AD agents and their therapeutic potential for AD through modulating the composition of gut microbiota.

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The extracts of Dracaena cochinchinensis stemwood suppress inflammatory response and phagocytosis in lipopolysaccharide-activated microglial cells

Cited by 3 publications

References 19 publications

Synergy of botanical drug extracts from Dracaena cochinchinensis stemwood and Ardisia elliptica fruit in multifunctional effects on neuroprotection and anti-inflammation

Synergy of botanical drug extracts from Dracaena cochinchinensis stemwood and Ardisia elliptica fruit in multifunctional effects on neuroprotection and anti-inflammation

The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases

Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

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