The extraordinary transformation of traditional Chinese medicine: processing with liquid excipients

Chen, Zhi; Ye, Si-Yong; Zhu, R. Y.

doi:10.1080/13880209.2020.1778740

Cited by 33 publications

(20 citation statements)

References 96 publications

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“…In clinical application, steaming with wine is often used to achieve the purpose of enhancing e ciency. As one of the commonly used adjuvants in processing, yellow rice wine can promote drug blood circulation and accelerate the release of effective components [37]. However, the Q-markers related to the e cacy of the WSC decoction pieces are still unclear, and the exclusive quality standard of WSC has not been established.…”

Section: Discussionmentioning

confidence: 99%

Screening of Q-markers for the wine-steamed Schisandra chinensis decoction pieces in improving allergic asthma

Bing

Zhang

et al. 2022

Preprint

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Background Traditional Chinese medicine (TCM) posits that Chinese medicinal materials can only be used for clinical use after being processed and prepared into decoction pieces. Schisandra Chinensis Fructus (derived from the dried and mature fruits of Schisandra chinensis (Turcz.) Baill.) has been traditionally used as an antiasthmatic, kidney strengthening, and hepatoprotective agent for 2000 years. TCM clinic believes that the decoction pieces of wine-steamed Schisandra chinensis (WSC) is advantageous over the raw decoction pieces of Schisandra chinensis (RSC) for cough and asthma. Studies have shown that steaming with wine can promote the dissolution of ingredients. However, the relationship between the changes of components in the decoction pieces of WSC and the therapeutic effect remains unclear. Methods The efficacy of the decoction of RSC and WSC were compared based on allergic asthma rats. The potential bioactive components in the serum of the WSC treatment group and the changes of chemical composition in the decoction pieces before and after wine steaming were determined by ultra-performance liquid chromatography quadrupole time-of-flight mass (UPLC-Q-TOF-MS/MS) analysis to speculate quality markers (Q-markers) related to the efficacy of WSC, which was further verified based on the zebrafish model of inflammation. Results: The results indicated the effect of RSC decoction pieces in improving allergic asthma was increased after being steamed with wine. Moreover, 12 components were detected in the serum of the WSC treatment group, which were conjectured to be the potential effective components. Among them, 5 components, such as Schisandrin, Schisandrol B, Schisandrin A, Schisandrin B, and Gomisin D, have higher dissolution rates than RSC after steaming with wine. The validation test based on the inflammatory zebrafish model showed that these 5 ingredients exerted their effects in a dose-dependent manner, demonstrating that they were Q-markers for WSC in the treatment of allergic asthma. Conclusion: This study clarified the changes of components of the decoction pieces of RSC and WSC and the Q-markers related to the WSC efficacy, which provide precious value for expanding the application of WVS and establishing its exclusive quality standard.

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Section: Discussionmentioning

confidence: 99%

Screening of Q-markers for the wine-steamed Schisandra chinensis decoction pieces in improving allergic asthma

Bing

Zhang

et al. 2022

Preprint

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“…Many methods of processing, such as stir-frying, steaming, and boiling, need to be carried out at the heating conditions, which probably leads to complex chemical changes [ 17 ]. In this study, AR was processed with salt water under the temperature range of 80 to 120 °C.…”

Section: Discussionmentioning

confidence: 99%

Changes in Triterpenes in Alismatis rhizoma after Processing Based on Targeted Metabolomics Using UHPLC-QTOF-MS/MS

Dai

Shi

et al. 2021

Molecules

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Alismatis rhizoma (AR) has been used as an herbal medicine in China for over a thousand years. Crude AR, salt-processed AR (SAR), and bran-processed AR (BAR) are recorded in the Pharmacopoeia of the People′s Republic of China. However, the differences of chemical composition between crude AR and its processing products remain limited. In this study, triterpenes were identified from crude AR, SAR, and BAR by ultra-high performance liquid chromatography coupled with quadrupole time-of-flight-mass spectrometer (UHPLC-QTOF-MS/MS). Subsequently, the differences of triterpenes between the crude AR and processed ARs were compared via a targeted metabolomics approach. Finally, a total of 114 triterpenes were identified, of which 83, 100, and 103 triterpenes were found in crude AR, SAR, and BAR, respectively. After salt-processing, there were 17 triterpenes newly generated, 7 triterpenes with trends of increasing, and 37 triterpenes decreased. Meanwhile, 56 triterpenes including 21 newly generated and 35 with significant increases were observed in BAR. This study could be benefit to investigate the processing mechanism of AR, as well as support their clinical applications.

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“…By adding vinegar and high-temperature processing, the components volatilize with the temperature rise, and the dissolution of active ingredient increase, which enhances the effect of dispersing the blood accumulation, soothing the liver, relieving pain, detoxification, and so on. [5][6][7][8] Under the condition of high temperature and acid, the material basis of CW changed significantly, resulting in both similarities and differences in its efficacy.…”

Section: Introductionmentioning

confidence: 99%

Based on UPLC/MS/MS and Bioinformatics Analysis to Explore the Difference Substances and Mechanism of Curcumae Radix (Curcuma wenyujin) in Dysmenorrhea

Qin

Fei

Zhang

et al. 2022

Chemistry & Biodiversity

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Background: Curcumae Radix (CW) is traditionally used to treat dysmenorrhea caused by uterine spasm. However, the changes of its composition and anti-uterine spasms during vinegar processing and the mechanism in treating dysmenorrhea are not clear. Objective: To elucidate the changes of anti-uterine spasm and its substance basis, and the mechanism of treating dysmenorrhea before and after vinegar processing. Methods:The uterine spasm contraction model was established, and the uterine activity and its inhibition rate were calculated to evaluate the differences. The main chemical constituents of CW were quickly analyzed by UPLC-Q-TOF-MS/MS technology, and the differences between them were explored by multivariate statistical analysis. Then, the regulatory network of "active ingredients-core targets-signal pathways" related to dysmenorrhea was constructed by using network pharmacology, and the combination between differential active components and targets was verified by molecular docking. Results: CW extract relaxed the isolated uterine by reducing the contractile tension, amplitude, and frequency. Compared with CW, the inhibitory effect of vinegar products was stronger, and the inhibition rate was 70.08 %. 39 compounds were identified from CW and 13 differential components were screened out (p < 0.05). Network pharmacology screened 11 active components and 32 potential targets, involving 10 key pathways related to dysmenorrhea. The results of molecular docking showed that these differentially active components had good binding activity to target. Conclusion: It was preliminarily revealed that CW could treat dysmenorrhea mainly through the regulation of inflammatory reaction, relaxing smooth muscle and endocrine by curcumenone, 13-hydroxygermacrone, (+)-cuparene, caryophyllene oxide, zederone, and isocurcumenol.

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The extraordinary transformation of traditional Chinese medicine: processing with liquid excipients

Cited by 33 publications

References 96 publications

Screening of Q-markers for the wine-steamed Schisandra chinensis decoction pieces in improving allergic asthma

Screening of Q-markers for the wine-steamed Schisandra chinensis decoction pieces in improving allergic asthma

Changes in Triterpenes in Alismatis rhizoma after Processing Based on Targeted Metabolomics Using UHPLC-QTOF-MS/MS

Based on UPLC/MS/MS and Bioinformatics Analysis to Explore the Difference Substances and Mechanism of Curcumae Radix (Curcuma wenyujin) in Dysmenorrhea

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