The Eyes in Mongolism

Characteristic ocular findings in Asian children with Down syndrome

“…The ocular findings in Korean children with DS are characterized as an unreported, high incidence of epiblepharon, the highest rate of exotropia and no cases of Brushfield spots. Although the ocular features of DS have been described in several studies (Table 4), [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] we could not find any reference to epiblepharon with DS in a computerized search utilizing Medline. It is surprising that epiblepharon has not been reported in other studies given the frequency in this study.…”

“…The overall incidence of ocular abnormalities in Korean children with DS (91%) was markedly higher than previously reported (Table 5). [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] This might be due to the preparation of a special examination sheet for DS documenting every reported ocular finding, slit-lamp biomicroscopy (before and after fluorescein instillation), cycloplegic refraction, and indirect ophthalmoscopic examination for every patient. The ocular findings in Korean children with DS are characterized as an unreported, high incidence of epiblepharon, the highest rate of exotropia and no cases of Brushfield spots.…”

“…2 However, the prevalence of exotropia in the whole strabismus was 42%, in contrast with the data in all other reports, which range from 0% to 19% (Table 4). [2][3][4][5][6][7][8][9][10][11][12]16 Asians are known to have a higher prevalence of exotropia than Caucasians or Africans in a normal population. 19 Racial factors may play a role in this strikingly high incidence.…”

“…1 Numerous ophthalmic features have been reported, including abnormalities of the eyelid, cornea, iris, lens, retina, and optic disc, as well as ametropia, amblyopia, strabismus, and nystagmus. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] The incidence of each ocular abnormality varies in different studies. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Most reported studies of ocular findings in DS have been performed in Caucasians.…”

“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] The incidence of each ocular abnormality varies in different studies. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Most reported studies of ocular findings in DS have been performed in Caucasians. [2][3][4][5][6][7][8][9][10][11][12][13][14][15] There are only a few reports in the literature that make reference to ocular findings in Asian patients with DS.…”