The fabrication and characterization of dicalcium phosphate dihydrate-modified magnetic nanoparticles and their performance in hyperthermia processes in vitro

Hou, Chun‐Han; Chen, Ching-wei; Hou, Sheng‐Mou; Li, Yuting; Lin, Fa‐Hsuan

doi:10.1016/j.biomaterials.2009.05.018

Cited by 48 publications

(33 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the class of calcium phosphate bone substitutes, calcium phosphate cements (CPCs) have unique self-setting property at body temperature, high mouldability with adequate biocompatibility and degradation rate [1,2,3]. One of the first orthopedic CPCs was formulated by Brown and Chow in 1986 [4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of silicon on osteoclast cell mediated degradation, in vivo osteogenesis and vasculogenesis of brushite cement

2015

View full text Add to dashboard Cite

Calcium phosphate cements (CPCs) are being widely used for treating small scale bone defects. Among the various CPCs, brushite (dicalcium phosphate dihydrate, DCPD) cement is widely used due to its superior solubility and ability to form new bone. In the present study, we have studied the physical, mechanical, osteoclast-like-cells differentiation and in vivo osteogenic and vasculogenic properties of silicon (Si) doped brushite cements. Addition of Si did not alter the phase composition of final product and regardless of Si level, all samples included β-tricalcium phosphate (β-TCP) and DCPD. 1.1 wt. % Si addition increased the compressive strength of undoped brushite cement from 4.78±0.21 MPa to 5.53±0.53 MPa, significantly. Cellular activity was studied using receptor activator of nuclear factor κβ ligand (RANKL) supplemented osteoclast-like-cells precursor RAW 264.7 cell. Phenotypic expressions of the cells confirmed successful differentiation of RAW264.7 monocytes to osteoclast-like-cells on undoped and doped brushite cements. An increased activity of osteoclast-like cells was noticed due to Si doping in the brushite cement. An excellent new bone formation was found in all cement compositions, with significant increase in Si doped brushite samples as early as 4 weeks post implantation in rat femoral model. After 4 weeks of implantation, no significant difference was found in blood vessel formation between the undoped and doped cements, however, a significant increase in vasculgenesis was found in 0.8 and 1.1 wt. % Si doped brushite cements after 8 weeks. These results show the influence of Si dopant on physical, mechanical, in vitro osteoclastogenesis and in vivo osteogenic and vasculogenic properties of brushite cements.

show abstract

Section: Introductionmentioning

confidence: 99%

“…One of the first orthopedic CPCs was formulated by Brown and Chow in 1986 [4]. Since then, several reports have been published on CPCs’ potential applications in bone defect filling, osteosynthetic screw reinforcement, pulp tissue engineering, and drug delivery [2,5,6]. …”

Section: Introductionmentioning

confidence: 99%

Effects of silicon on osteoclast cell mediated degradation, in vivo osteogenesis and vasculogenesis of brushite cement

2015

View full text Add to dashboard Cite

show abstract

“…This decreasing trend in magnetization is mainly due to the presence of non-magnetic silica phase and it is due to the presence of excess SiO 2 particles, the effective mass of α-Fe 2 O 3 gets reduced thereby leading to the strong loss in magnetization [24]. It has been stated in many research works that the magnetization values even in the range of 1 emu/g could be used for cancer treatment, [25][26][27].…”

Section: Magnetic Studiesmentioning

confidence: 99%

In-situ synthesis, structural, magnetic and in vitro analysis of α-Fe2O3–SiO2 binary oxides for applications in hyperthermia

Deka

Singh

Kannan

2015

Ceramics International

View full text Add to dashboard Cite

“…The relationship was based on temperature dependence of the proton chemical shift of water < 0.01 ppm/ºC at < 0.7 Hz at 1.5T for 1 ºC temperature change using lanthanide complexes [141]. [142][143][144][145].…”

Section: Lanthanum Complexmentioning

confidence: 99%

State of Art on Bioimaging by Nanoparticles in Hyperthermia and Thermometry: Visualization of Tissue Protein Targeting

Sharma¹,

Sharma²,

Chen³

2011

TONMJ

View full text Add to dashboard Cite

Abstract:Heating tumors by nanoparticles and resistance in tumor cells to a high temperature is emerging as an effective tool as nanomedicine tool in cancer therapy. The art of thermal mapping in a tumor at various locations is emerging as the selective approach of hyperthermia to monitor temperature and treat the tumor. However, thermometry and tumor cell interaction with nanoparticles may monitor and evaluate the tumor cell survival after exposure to high physiological temperatures but show cytotoxicity. The design and application of 10-100 nano meter sized nanoparticles in tumor hyperthermia has emerged as an effective technology in hyperthermia imaging and treatment. The temperature and nanoparticle magnetic moment relationship is specific. Furthermore, there are two main issues that are unsolved as of yet. First issue is the relationship of tumor energy changes due to tumor magnetization by different nanoparticles. The second issue is the heat transfer behavior of the nanoparticle inside the tumor combined with hyperthermia and efficacy of combined modality on the tumor tissue temperature rise. In present study, we highlight that in vivo imaging such as MR thermometry, photoacuastic mapping of different tumor locations solve these issues to some extent. The art of combined use of hyperthermia by nanoparticles with hypoxia sensitive nitroimidazole radiosensitizers with chemotherapeutic drugs is highlighted to have a great impact on public health as alternative therapeutic oncology and monitoring therapy.

show abstract

The fabrication and characterization of dicalcium phosphate dihydrate-modified magnetic nanoparticles and their performance in hyperthermia processes in vitro

Cited by 48 publications

References 21 publications

Effects of silicon on osteoclast cell mediated degradation, in vivo osteogenesis and vasculogenesis of brushite cement

Effects of silicon on osteoclast cell mediated degradation, in vivo osteogenesis and vasculogenesis of brushite cement

In-situ synthesis, structural, magnetic and in vitro analysis of α-Fe2O3–SiO2 binary oxides for applications in hyperthermia

State of Art on Bioimaging by Nanoparticles in Hyperthermia and Thermometry: Visualization of Tissue Protein Targeting

Contact Info

Product

Resources

About