The fabrication of a supra-amphiphile for dissipative self-assembly

Wang, Guangtong; Tang, Bohan; Liu, Yang; Gao, Qingyu; Wang, Zhiqiang; Zhang, Xi

doi:10.1039/c5sc03907j

Cited by 80 publications

(52 citation statements)

References 44 publications

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“…In contrast with conventional amphiphiles, there appears an emerging field of supra‐amphiphiles, which refer to amphiphiles fabricated on the basis of various noncovalent interactions and/or dynamic covalent bonds, such as host‐guest interaction, electrostatic interaction, charge‐transfer interaction, hydrogen bond, coordination bond, imine bond and boronic ester bond . Generally, the strategies for designing supra‐amphiphiles can be sorted into two main categories .…”

Section: Introductionmentioning

confidence: 99%

Supra‐Amphiphiles for Functional Assemblies

Kang

Tang

Cai

et al. 2016

Adv Funct Materials

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wileyonlinelibrary.comVarious building blocks can be used to fabricate supra-amphiphiles, ranging from small molecules to polymers, from synthetic compounds to natural chemicals. [31][32][33][34][35][36] The preparation method is adapted to the solubility of these building blocks. The simplest method is to mix all the building blocks together in water or other solvent simultaneously. According to the fast dynamics of the noncovalent interactions, the supra-amphiphiles can spontaneously form and self-assemble in a short time. When some of the building blocks are not readily soluble in water, a good solvent for all building blocks is usually applied. For example, as shown in Figure 1, we mixed a nitrobenzene derivative (DNB) and a pyrene derivative (PYR) in tetrahydrofuran (THF), which is a good solvent for DNB and PYR. [37] The supra-amphiphile could form on the basis of the charge-transfer interaction. The PYR, which was a conventional amphiphile, self-assembled in water to form tubular structures, while the supra-amphiphiles could self-assemble in water to form vesicles. Therefore, the formation of supra-amphiphiles can be regarded as the first-level self-assembly based on the noncovalent synthesis of covalent components, and then the supra-amphiphiles can undergo second-level self-assembly to form well-defined organizations.Abundant studies have been reported on the design, fabrication and application of supra-amphiphiles. In this feature article, we would like to introduce recent progresses of supra-amphiphiles from molecular architecture to functional assemblies. Limited by the volume of this article and our knowledge, it is impossible to cover every aspect of this developing area, therefore, we will put special emphasis on a few topics where supra-amphiphiles function as surfactants, and in the areas of nanocarriers, photodynamic therapies, chemical analysis and functional interfaces. Hopefully, it can reflect in a way that the study on supra-amphiphiles is enriching the molecular engineering of supramolecular systems by combining the molecular architecture and functional assembly. Supra-Amphiphiles as SurfactantsSurfactants, referring to surface-active reagents which can induce significant decrease in interfacial tension by adsorption, are crucial substances for colloidal research, industrial applications as well as our daily life. Supra-amphiphiles can also be utilized as surfactants, functioning in emulsification, foaming, etc. As there is more flexibility in the structure of supra-amphiphiles compared to that of the covalent counterparts, finer tuning of interfacial tension and other physicochemical properties can be realized. In addition, the feature of noncovalent Supra-amphiphiles refer to amphiphiles which are fabricated on the basis of various noncovalent interactions and dynamic covalent bonds, including host-guest interaction, charge-transfer interaction, electrostatic interaction, imine bonds, etc. In this feature article, recent progresses of supra-amphiphiles from molecular architecture to func...

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Section: Introductionmentioning

confidence: 99%

Supra‐Amphiphiles for Functional Assemblies

Kang

Tang

Cai

et al. 2016

Adv Funct Materials

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“…[58] Except for the groups like Ru(bpy) 3 , which itself is an indispensable component of the oscillatory reaction, other structures that can respond to the oscillatory component of an oscillatory reaction can also be applied for constructing a fueldriven oscillatory self-assembly. [59][60][61][62] In 2010, B. A. Grzybowski and co-workers realized the oscillatory self-assembly of surfactants based on oleic acid by coupling them with methylene glycol-sulfite-gluconolactone (MGSG) chemical oscillator, in which pH changed periodically.…”

Section: Oscillatory Reactionsmentioning

confidence: 99%

“…[60] In 2016, X. Zhang and his co-workers used the IO 3À À NH 3 OH + chemical oscillator to realize the oscillatory selfassembly of a polymeric supra-amphiphile. [61] The I 2 -responsive PEO chain in the supra-amphiphile allowed its assembly to be controlled by the IO 3À À NH 3 OH + oscillator, in which I 2 was periodically produced. Furthermore, they also tried to use the theoretical modeling of IO 3À À NH 3 OH + oscillator to estimate the kinetic data of the I 2 -responsive self-assembly of the polymeric supra-amphiphile, which are difficult to monitor directly, providing a new possible strategy to study the kinetics of stimuli-responsive molecular self-assembly.…”

Section: Oscillatory Reactionsmentioning

confidence: 99%

Strategies to Construct a Chemical‐Fuel‐Driven Self‐Assembly

Wang

Liu

2020

ChemSystemsChem

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Fuel-driven self-assembly widely exists in the biological world since functional micro-or nanostructures in living bodies are usually transiently formed by biomolecular self-assembly far from thermodynamic equilibrium driven by active molecules (chemical fuel), for example, adenosine triphosphate (ATP). Therefore, research focusing on artificial fuel-driven self-assembly has drawn extensive attention in recent years. Compared with spontaneous molecular self-assembly at thermodynamic equilibrium, constructing a fuel-driven self-assembly remains complicated because it requires a delicately designed chemical reaction network mainly involving an "activation" and a "deactivation". In this Minireview, we will review recent developments in fuel-driven self-assembly and generalize several strategies for constructing such a self-assembly. Besides that, the functional micro-or nanostructures and materials achieved by these fuel-driven self-assemblies will also be discussed.

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“…Compared with amphiphilic covalent macromolecules, macromolecular supra‐amphiphiles are more promising due to their dynamic and reversible nature of noncovalent interactions . The introduction of noncovalent forces can endow macromolecular supra‐amphiphiles abundant stimuli‐responsiveness, such as light, pH, temperature, redox and so on, which significantly enhances the versatility of these materials in the drug release field. Therefore, it is of great importance to develop multiresponsive macromolecular supra‐assemblies and thus broaden their application fields.…”

Section: Introductionmentioning

confidence: 99%

Dual-responsive supramolecular self-assembly of inclusion complex of an azobenzene-ended poly(ε-caprolactone) with a water-soluble pillar[6]arene and its application in controlled drug release

Tong

Zhou

Huang

et al. 2017

J. Polym. Sci. Part A: Polym. Chem.

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Dual photo-and pH-responsive polymeric vesicles are constructed from a host-guest complex between a watersoluble pillar[6]arene and an azobenzene ended functionalized poly(e-caprolactone). Reversible morphological transitions between vesicles and solid aggregates are achieved upon repeated UV stimulus and pH stimulus. Moreover, the polymeric vesicles present excellent cytocompatibility toward HepG2 cells and can be further applied for controlled release of a hydrophilic model drug, DOX•HCl.

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The fabrication of a supra-amphiphile for dissipative self-assembly

Cited by 80 publications

References 44 publications

Supra‐Amphiphiles for Functional Assemblies

Supra‐Amphiphiles for Functional Assemblies

Strategies to Construct a Chemical‐Fuel‐Driven Self‐Assembly

Dual-responsive supramolecular self-assembly of inclusion complex of an azobenzene-ended poly(ε-caprolactone) with a water-soluble pillar[6]arene and its application in controlled drug release

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