The facile preparation of p-(methoxy)calix[n]arenes (n = 6, 7, or 8) and their permethylated derivatives

The Structure Determination of Organic Molecules by Co-crystallization of Anthracene-Based Crystallization Chaperone

“…Whether the organic compounds are natural products − or synthesized by chemists, it is extremely important to determine their structures and absolute conformations at the atomic level. Over the past few decades, numerous researchers have developed and refined many methods for the structural identification of organic molecules, such as nuclear magnetic resonance ( NMR ), − infrared spectroscopy ( IR ), − mass spectrometry ( MS ), − single crystal X-ray diffraction ( X-ray SCD ), − etc. Among them, X-ray SCD can provide direct and accurate structural information and is globally recognized as a fairly reliable method for the structural identification of organic compounds, including their stereochemical conformation.…”

“…TMAPA as a novel crystallization chaperone with 9-methoxy anthracene moieties was successfully synthesized by the classical Suzuki coupling reaction 62 between intermediates 1 and 2 that both were prepared in good quantities by commercially available reagents (Figure 1a and Figures S1 and S2 in the Supporting Information). After TMAPA was prepared, 1 H NMR (Figure S10) and 13 C NMR (Figure S11) of the resulting compound showed its successful synthesis. And further, the yellow single crystals of TMAPA were smoothly obtained by slowly cooling its hot saturated tetrahydrofuran (THF) solution, and they were measured using the X-ray method to obtain the high-resolution single-crystal structure of TMAPA.…”

Water soluble macrocyclic host for recognition of N-methylquinolinium salts in water

“…Macrocyclic arenes composed of hydroxyl-substituted aromatic rings bridged by methylene or methenyl groups have attracted considerable attention for their wide application in molecular recognition and assembly, biomedicine, materials science, and adsorption separation. [1][2][3][4][5][6][7][8][9] Good examples are calixarenes, [10][11][12] pillar[n]arenes, [13][14][15][16] prism [5]arene, 17 pagoda[n]arene, 18,19 geminiarenes, 20,21 tiara [5]arene, 22,23 biphen[n]arenes, [24][25][26] helic [6] arene [27][28][29] and so on. 30,31 Although a large number of macrocyclic arenes have been reported in the last decade.…”