The factor analysis approach to mortality prediction in COVID-19 severe disease using laboratory values: a retrospective study

Kara, Umut; ŞİMŞEK, Fatih; Özhan, Mehmet Özgür; Ince, Mehmet; Özkan, Gökhan; ŞENKAL, Serkan; COŞAR, Ahmet

doi:10.32322/jhsm.1052191

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…CRP values above 130 mg/L were found to be associated with mortality. In our study, a statistically significant increase in CRP levels was found in the non-survivor group compared with the survivor group (p<0.001) (36)(37) In our study, a relationship between a decrease in albumin levels and mortality was shown. In addition, when clinically important variable logistic regression analysis was performed, it was observed that the albumin ratio was AUC 0.681 (95% CI: [0.621-0.742]; p<0.001), and albumin had high sensitivity in predicting mortality (84.5%).…”

Section: Discussionsupporting

confidence: 59%

The relationship of laboratory parameters and mortality of patients followed in intensive care units with COVID-19

GÖLEN¹,

OKUYAN²,

Tutar³

et al. 2022

Journal of Health Sciences and Medicine

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Aim: We aimed to evaluate the parameters associated with mortality in COVID-19 patients followed up in the intensive care unit. Material and Method: Three hundred twenty-one patients followed up with the diagnosis of COVID-19 were included in the study. Demographic characteristics, laboratory and clinical parameters were compared in patients with and without mortality. Results: A higher intubation rate (98.6% vs. 10.9%) and longer hospitalization (10.0 vs. 8.0 days) were detected in the non-survivor group (p

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Section: Discussionsupporting

confidence: 59%

The relationship of laboratory parameters and mortality of patients followed in intensive care units with COVID-19

GÖLEN¹,

OKUYAN²,

Tutar³

et al. 2022

Journal of Health Sciences and Medicine

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“…B.1.1.7 variant has 17 mutations, including eight in the spike protein. Mutations affect the binding affinity to human angiotensin-converting enzyme 2 (ACE2) and entry into human cells which increase the infectivity (2)(3)(4) and changed the clinical presentation, morbidity and mortality of the disease (2,5,6). Due to the worse clinical presentation, we think that there may be differences in the radiological findings of the B.1.1.7 variant induced pneumonia compared to the Wuhan type.…”

Section: Introductionmentioning

confidence: 99%

Radiological comparison of the Wuhan and B.1.1.7 variant COVID-19 infection; are there any differences in chest CT scans?

Demircioglu

Kocakaya

Çimşit

et al. 2022

Journal of Health Sciences and Medicine

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Aim: In September 2020, a variant of the SARS-CoV-2 virus was detected in England and it became the dominant type in most of the countries. The clinical behavior of the B.1.1.7 variant COVID-19 infectionis different from the Wuhan type.So we aimed to investigate whether there are any differences in computed tomography (CT) imaging findings of pneumonia caused by COVID-19 variants. Material and Method: 340 patients who admitted to the emergency departmentwith symptoms of dyspnea and chest pain suspecting COVID-19 pneumonia and pulmonary embolism were included in the study. Oncology (n:12) and pediatric (n:8) patients, patients with negative PCR test (n:56), and patients infected with different variant (n:6) were excluded leaving 258 patients grouped into two (B.1.1.7 and Wuhan type) for evaluation of CT findings such as pleural thickening,pleural and pericardial effusion, consolidation, GGO presence and distribution, upper lobe involvement, pulmonary embolism, tree in bud pattern, centrilobuler nodule, revers halo sign, and hepatosteatosis. Results: A statistically significant difference was obtained between the two groups in terms of pleural thickening (p=0.020), upper lobe involvement (p=0.037), localization of GGO (p=0.001), presence of pleural effusion (p=0.025), embolism (p=0.011) and presence of consolidation (p=0.042). However, no significant difference was found for the development of hepatosteatosis (p=0.520). Conclusion: There aredifferences in radiological findings between B.1.1.7 variant and Wuhan type. In our study atypical radiological findings are more common in B.1.1.7 type. In addition, radiological findings that seen in severe COVID-19 pneumonia are more common in B.1.1.7.

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“…The biochemical tests used routinely provide clinicians with important data about COVID-19. Many studies have been conducted to date on the effect of biochemical parameters on mortality in COVID-19 patients, and some risk factors have been found, such as comorbid diseases, D-dimer, and troponin (8)(9)(10)(11)(12). However, the number of publications evaluating the effect of arterial blood gases such as lactate, base excess, and bicarbonate on mortality is very few and the clinical consequences of these results during the first admission remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Base excess, bicarbonate, and lactate levels predict 28-day mortality in patients with COVID-19: a retrospective study

Saruhan

ÖZDEMİR

Acar

2022

Anatolian Current Medical Journal

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Aim: It is critical to categorize the risk factors that could disclose the severity of COVID-19. This study aimed to determine the effects of arterial blood gases on hospital mortality by examining the results retrospectively measured at the first admission to the emergency department of cases diagnosed with COVID-19. Material and Method: In this retrospective study, arterial blood gases of patients with COVID-19 were analyzed using univariate analysis to identify factors linked to 28-day all-cause in-hospital mortality. The patients were divided into two groups survivors and nonsurvivors. Results: The study included 159 survivors and 33 nonsurvivors with COVID-19. Serum levels of lactate, D-dimer, troponin, and CRP were higher and serum levels of base excess, bicarbonate, and albumin to creatinine ratio were lower in nonsurvivor patients than in survivors. The highest AUC was found for lactate and base excess. Conclusion: The arterial blood gases performed during the first admission to the emergency department are linked with disease severity and can be used to predict disease progression and mortality. Furthermore, patients with higher levels of lactate and lower levels of base excess and bicarbonate should be monitored closely and treated early.

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The factor analysis approach to mortality prediction in COVID-19 severe disease using laboratory values: a retrospective study

Cited by 4 publications

References 19 publications

The relationship of laboratory parameters and mortality of patients followed in intensive care units with COVID-19

The relationship of laboratory parameters and mortality of patients followed in intensive care units with COVID-19

Radiological comparison of the Wuhan and B.1.1.7 variant COVID-19 infection; are there any differences in chest CT scans?

Base excess, bicarbonate, and lactate levels predict 28-day mortality in patients with COVID-19: a retrospective study

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