The factor V Leiden mutation, high factor VIII, and high plasminogen activator inhibitor activity: etiologies for sporadic miscarriage

Glueck, Charles J.; Pranikoff, Joel; Aregawi, D.; Haque, M.; Zhu, Bing; Tracy, Trent; Wang, Ping

doi:10.1016/j.metabol.2005.04.024

Cited by 26 publications

(31 citation statements)

References 48 publications

(77 reference statements)

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“…Sample size calculations (36) were done, based on an estimated 3% Cincinnati area prevalence of the FVL mutation (37) and assuming a 12% FVL prevalence (24) in sporadic pregnancy loss cases with alpha .05 and power .80.…”

Section: Methodsmentioning

confidence: 99%

“…Plasminogen activator inhibitor activity (PAI-Fx) was high (R21.1 U/ mL) in 21 (33%) of 63 cases with sporadic miscarriage versus 27 (18%) of 152 control subjects (P¼.013). Factor VIII was high (>150%) in 15 (31%) of 48 case subjects versus 19 (18%) of 103 control subjects (P¼.079) (24). We concluded (24) that the thrombophilic FVL gene mutation was a common, significant, and treatable (9,21,24,25) cause of both sporadic pregnancy loss and RPL.…”

mentioning

confidence: 85%

“…We recently compared the frequency of the FVL mutation in 92 women with R1 pregnancy and 1 sporadic pregnancy loss, in 72 women with RPL, and in 380 female control subjects with R1 pregnancy and 0 pregnancy losses (24). We also assessed other heritable and acquired thrombophilias and hypofibrinolysis in the 92 women with R1 pregnancy and 1 sporadic pregnancy loss (24).…”

mentioning

confidence: 99%

“…We also assessed other heritable and acquired thrombophilias and hypofibrinolysis in the 92 women with R1 pregnancy and 1 sporadic pregnancy loss (24). Of the 380 control subjects, 6 (1.6%) had FVL heterozygosity versus 12 heterozygous and 2 homozygous FVL cases with sporadic pregnancy loss (14/92, 15.2%; P<.0001) (24). Plasminogen activator inhibitor activity (PAI-Fx) was high (R21.1 U/ mL) in 21 (33%) of 63 cases with sporadic miscarriage versus 27 (18%) of 152 control subjects (P¼.013).…”

mentioning

confidence: 99%

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Factor V Leiden mutation: a treatable etiology for sporadic and recurrent pregnancy loss

Glueck

Gogenini

Munjal

et al. 2008

Fertility and Sterility

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 85%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Factor V Leiden mutation: a treatable etiology for sporadic and recurrent pregnancy loss

Glueck

Gogenini

Munjal

et al. 2008

Fertility and Sterility

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“…Various studies in the recent years have been examined the incidence of specific thrombophilic gene mutations in women with unexplained spontaneous abortion. Some of these studies have been demonstrated an association between thrombophilic gene mutations and abortions (11)(12)(13) whereas others have shown the lack of any association (14-16).…”

Section: Discussionmentioning

confidence: 99%

Thrombophilic Status of Extracted Fetal Tissues of Spontaneously Aborted Embroys

2017

GMJ

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Objective:The reports about Factor V (FV) Leiden, Factor II (FII) G20210A and Methylenetetrahydrofolate reductase (MTHFR) C677T gene mutations of parents and fetal viability are frequently encountered in the literature, despite the fetal side of thrombophilia is scant. To clarify the three common thrombophilic gene mutations of the spontaneously aborted embryos, an accurate algorithm was followed to extract the fetal tissues and then the mutations were searched. Material and Methods:70 spontaneous abortion materials were included to the study and all were karyotyped. Cytogenetically abnormals were excluded from the study. To extract the fetal tissues, amplifications of sex determination region of chromosome-Y (SRY) gene and genotypings were performed, respectively. Extracted fetal tissues of spontaneous aborted embroys and parents were screened for the thrombophilic gene mutations via electronic microarray. Results:After excluding chromosomally abnormal and maternally contaminated ones totally ten fetal tissues were screened for the FII G20210A, FV Leiden and MTHFR C677T gene mutations, and two carry F II G20210A and F Leiden heterozygote mutations, and six carry heterozygote forms of MTHFR C677T. Conclusion:The present study performed on the limited number of abortion materials, has a value for distinguishing the fetal tissues before analyzing the three common mutation of thrombophilic genes which make the results are very substantial.

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High FVIII Level Is Associated with Idiopathic Portal Vein Thrombosis in South India

Koshy

Jeyakumari

2007

The American Journal of Medicine

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The factor V Leiden mutation, high factor VIII, and high plasminogen activator inhibitor activity: etiologies for sporadic miscarriage

Cited by 26 publications

References 48 publications

Factor V Leiden mutation: a treatable etiology for sporadic and recurrent pregnancy loss

Factor V Leiden mutation: a treatable etiology for sporadic and recurrent pregnancy loss

Thrombophilic Status of Extracted Fetal Tissues of Spontaneously Aborted Embroys

High FVIII Level Is Associated with Idiopathic Portal Vein Thrombosis in South India

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