The factors affecting neurogenesis after stroke and the role of acupuncture

Abstract

Stroke induces a state of neuroplasticity in the central nervous system, which can lead to neurogenesis phenomena such as axonal growth and synapse formation, thus affecting stroke outcomes. The brain has a limited ability to repair ischemic damage and requires a favorable microenvironment. Acupuncture is considered a feasible and effective neural regulation strategy to improve functional recovery following stroke via the benign modulation of neuroplasticity. Therefore, we summarized the current research progress on the key factors and signaling pathways affecting neurogenesis, and we also briefly reviewed the research progress of acupuncture to improve functional recovery after stroke by promoting neurogenesis. This study aims to provide new therapeutic perspectives and strategies for the recovery of motor function after stroke based on neurogenesis.

Annexin A6 mitigates neurological deficit in ischemia/reperfusion injury by promoting synaptic plasticity

“…This limited functional recovery may be due to limited neurogenesis. 31 Axon sprouting, synapse remodeling, and central microenvironment regulation have been identified as targets for alleviating post-stroke neurological deficits. 31 Synaptophysin belongs to the synaptic vesicle membrane protein family and is widely distributed in brain tissue.…”

“…31 Axon sprouting, synapse remodeling, and central microenvironment regulation have been identified as targets for alleviating post-stroke neurological deficits. 31 Synaptophysin belongs to the synaptic vesicle membrane protein family and is widely distributed in brain tissue. Synaptophysin is highly expressed during synaptogenesis, regulating synapse formation and synaptic vesicle cycling.…”

“…However, poststroke function recovery is extremely limited, causing long‐term neurological dysfunction. This limited functional recovery may be due to limited neurogenesis 31 . Axon sprouting, synapse remodeling, and central microenvironment regulation have been identified as targets for alleviating post‐stroke neurological deficits 31 …”

“…This poststroke neuroplasticity involves reconstructing neural networks and functional responses in neurogenic niches 32 . Increased plasticity allows neurogenesis, including axon sprouting, synapse generation, and neurological function remapping 31 . Neuroplasticity is vital for recovering cerebral function after injury 33 .…”

“…Neuroplasticity refers to the capacity of the brain to adapt to its current microenvironment during growth and development. Even after a stroke, the brain tissue retains neuroplasticity 31 . This poststroke neuroplasticity involves reconstructing neural networks and functional responses in neurogenic niches 32 .…”