The Factors Associated With Tumor Stability Observed With Conservative Management of Intracanalicular Vestibular Schwannoma

Lee, Jong Dae; Park, Moo Kyun; Kim, Jong Sei; Cho, Yang Sun

doi:10.1097/mao.0000000000000338

Cited by 19 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, it would be helpful to identify predictive factors for VS growth at time of diagnosis. Several epidemiological, clinical, and radiological characteristics were thought to be related to the increased risk of subsequent tumor growth, such as patients' age, tumor location, hearing loss, and grow at first follow-up (9,(12)(13)(14). But there were some inconsistencies among reports of predicting growth-related factors (9), making the accuracy of this approach debatable.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, observation policy carries the inherent risk of tumor progression and hearing deterioration in growing tumors, which emphasizing the importance of the identification of effective and convenient indicators to predict growth characteristics at the time of diagnosis to weigh the benefits and risks of active treatment against watchful observation. Previous studies have reported onset at an early age, increasing size in the first year, hearing loss, extrameatal tumor location, cerebellopontine angle extension, sway velocity with eyes open were risk factors for tumor growth (9,(12)(13)(14)(15). Here, we provide a narrative review on the topic of biomarkers currently considered to be related to VS growth in order to assist surgeons to select the most accurate treatment approach and the development of innovative targeted therapies.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Potential Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects

et al. 2021

View full text Add to dashboard Cite

Vestibular schwannomas (VSs, also known as acoustic neuromas) are relatively rare benign brain tumors stem from the Schwann cells of the eighth cranial nerve. Tumor growth is the paramount factor for neurosurgeons to decide whether to choose aggressive treatment approach or careful follow-up with regular magnetic resonance imaging (MRI), as surgery and radiation can introduce significant trauma and affect neurological function, while tumor enlargement during long-term follow-up will compress the adjacent nerves and tissues, causing progressive hearing loss, tinnitus and vertigo. Recently, with the deepening research of VS biology, some proteins that regulate merlin conformation changes, inflammatory cytokines, miRNAs, tissue proteins and cerebrospinal fluid (CSF) components have been proposed to be closely related to tumor volume increase. In this review, we discuss advances in the study of biomarkers that associated with VS growth, providing a reference for exploring the growth course of VS and determining the optimal treatment strategy for each patient.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects

et al. 2021

View full text Add to dashboard Cite

show abstract

“…After abstract review, 61 articles were included for complete paper evaluation. Twenty-six publications met inclusion criteria (Table 1) (19–21,24–46). Of these studies, 25 were single-center and one was population-based.…”

Section: Resultsmentioning

confidence: 99%

Hearing Preservation in Observed Sporadic Vestibular Schwannoma: A Systematic Review

Khandalavala

Saba

Kocharyan

et al. 2022

Otology &Amp; Neurotology

View full text Add to dashboard Cite

ObjectiveTo characterize the natural history of hearing loss for patients presenting with serviceable hearing (SH) who undergo a wait-and-scan approach for sporadic vestibular schwannoma (VS) using aggregate time-to-event survival analysis.Study DesignSystematic review.SettingPublished international English literature, January 1, 2000 to May 31, 2020.PatientsPatients with sporadic VS entering a wait-and-scan approach with SH at diagnosis.InterventionsObservation with serial MRI and audiometry.ResultsIn total, 3,652 patients from 26 studies were included for analysis. Mean age at diagnosis was 58.8 years (SD, 4.1). Mean follow-up was 49.2 months (SD, 26.5). In total, 755 patients (21%) failed conservative treatment and underwent radiosurgery or microsurgery at the time of last follow-up. The average loss to follow-up was 6.9% (SD, 11.1). A total of 1,674 patients had SH at the time of diagnosis. Survival rates for maintaining SH were 96% at 1 year, 77% at 3 years, 62% at 5 years, and 42% at 10 years following diagnosis.ConclusionIn this systematic review, aggregate data from 3,652 patients across 26 studies show consistent patterns in progression of hearing loss during observation for patients with sporadic VS as a function of time. As an easy-toremember conservative benchmark for those presenting with SH at diagnosis: approximately 75% retain SH at 3 years, 60% at 5 years, and 40% at 10 years.

show abstract

“…The average tumour size at diagnosis varied from 5.1 mm 20 to 20.1 mm. 26 No average value was reported in five articles; 22,29,35,36,38 two articles 30,33 included intra-canalicular tumours only, two articles 23,39 included intra-canalicular tumours and up to 2 cm of extra-canalicular tumours, while one article 34 considered tumour volume. We calculated the weighted average diameter of tumours at diagnosis as 9.32 mm.…”

Section: Resultsmentioning

confidence: 99%

Screening for vestibular schwannoma in the context of an ageing population

Basu¹,

Youngs²,

Mitchell‐Innes

2019

J. Laryngol. Otol.

View full text Add to dashboard Cite

ObjectiveTo review the literature regarding screening for vestibular schwannoma in the context of demographic changes leading to increasing numbers of elderly patients presenting with asymmetric auditory symptoms.MethodsA systematic review of the literature was performed, with narrative synthesis and statistical analysis of data where appropriate.ResultsVestibular schwannomas diagnosed in patients aged over 70 years exhibit slower growth patterns and tend to be of smaller size compared to those tumours in younger age groups. This fact, combined with reduced life expectancy, renders the probability of these tumours in the elderly requiring active treatment with surgery or stereotactic radiotherapy to be extremely low. Vestibular schwannomas in the elderly are much more likely to be managed by serial monitoring with magnetic resonance imaging. The weighted yield of magnetic resonance imaging in the diagnosis of vestibular schwannoma in all age groups is 1.18 per cent, with almost 85 scans required to diagnose 1 tumour.ConclusionAn evidence-based approach to the investigation of asymmetric hearing loss and tinnitus in the elderly patient can be used to formulate guidelines for the rational use of magnetic resonance imaging in this population.

show abstract

The Factors Associated With Tumor Stability Observed With Conservative Management of Intracanalicular Vestibular Schwannoma

Abstract: Patients with ICVS showed favorable results with conservative management. Among them, patients with small tumors and normal hearing showed a good prognosis.

Cited by 19 publications

References 22 publications

Potential Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects

Potential Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects

Hearing Preservation in Observed Sporadic Vestibular Schwannoma: A Systematic Review

Screening for vestibular schwannoma in the context of an ageing population

Contact Info

Product

Resources

About