The factors influencing peripapillary choroidal thickness in primary open-angle glaucoma

Ersöz, Mehmet Giray; Mart, Duygu Kunak; Ayıntap, Emre; Hazar, Leyla; Güneş, İrfan Botan; Adıyeke, Seda Karaca; Dogan, Beysim

doi:10.1007/s10792-016-0346-9

Cited by 11 publications

(8 citation statements)

References 22 publications

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“…Although it may also be the case that the choroid is thicker in Korean eyes, Chung et al33 measured PCT using Spectralis circle scans in 87 healthy Korean eyes and reported an average thickness of 157.3 μm, which is within the confidence intervals of our measurements at 900 and 1000 μm (roughly the position of a standard circle scan within our data). Several other studies have reported global PCT within standard 12° (or 3.4 mm diameter) circle scans in a wide variety of healthy participants that varies from 130 μm to 167 μm,34–42 which are again within the confidence intervals of our measurements at the PCT-900 μm and PCT-1000 μm measurement points.…”

Section: Discussionsupporting

confidence: 87%

Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study

Yang

Luo

Gardiner

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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Purpose To quantify peripapillary choroidal thickness (PCT) and the factors that influence it in healthy participants who represent the racial and ethnic composition of the U.S. population. Methods A total of 362 healthy participants underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head with a 24 radial B-scan pattern aligned to the fovea to Bruch's membrane opening axis. Bruch's membrane, anterior scleral canal opening (ASCO), and the anterior scleral surface were manually segmented. PCT was measured at 100, 300, 500, 700, 900, and 1100 μm from the ASCO globally and within 12 clock-hour sectors. The effects of age, axial length, intraocular pressure, ethnicity, sex, sector, and ASCO area on PCT were assessed by ANOVA and univariable and multivariable regressions. Results Globally, PCT was thicker further from the ASCO border and thinner with older age, longer axial length, larger ASCO area, European descent, and female sex. Among these effectors, age and axial length explained the greatest proportion of variance. The rate of age-related decline increased further from the ASCO border. Sectorally, the inferior-temporal sectors were thinnest (10.7%–20.0% thinner than the thickest sector) and demonstrated a higher rate of age-related loss (from 15.6% to 20.7% faster) at each ASCO distance. Conclusions In healthy eyes, PCT was thinnest in the inferior temporal sectors and thinner PCT was associated with older age, European descent, longer axial length, larger ASCO area, and female sex. Among these associations, age had the strongest influence, and its effect was greatest within the inferior temporal sectors.

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Section: Discussionsupporting

confidence: 87%

Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study

Yang

Luo

Gardiner

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…[27][28][29] Nonetheless, others claimed that the peripapillary choroidal thickness in glaucomatous eyes was obviously thinner than that in eyes of normal or glaucoma suspects. [30][31][32] Regarding factors related to the width of deep VD, IOP was the most in uential factor. In line with this nding, Ersoz et al 32 reported that higher IOP was signi cantly associated with the peripapillary choroidal thickness, while the parameters, including MD, RNFLT, and lamina and prelaminar thicknesses were not.…”

Section: Discussionmentioning

confidence: 99%

“…[30][31][32] Regarding factors related to the width of deep VD, IOP was the most in uential factor. In line with this nding, Ersoz et al 32 reported that higher IOP was signi cantly associated with the peripapillary choroidal thickness, while the parameters, including MD, RNFLT, and lamina and prelaminar thicknesses were not. According to Maul et al, 27 signi cant relationships were found between the peripapillary choroidal thickness and higher IOP, lower diastolic ocular and blood perfusion pressures.…”

Section: Discussionmentioning

confidence: 99%

Determinants of Vessel Defects in Superficial and Deep Vascular Layers in Normal-Tension Glaucoma Using Optical Coherence Tomography Angiography

Lee

Park

2021

Preprint

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We investigated the characteristics of localized vessel density defects (VD) either in the deep or superficial vascular layer of normal-tension glaucoma patients using optical coherence tomography angiography (OCTA). In this retrospective, cross-sectional study, 74 eyes with localized retinal nerve fiber layer (RNFL) defect were included. The relationships between the widths of the VD in the superficial and deep layer and ocular factors were evaluated. Eyes with greater deep VD were significantly older (P = 0.023). Baseline and treated IOPs were significantly related to the width of the deep VD (P=0.009 and 0.014, respectively). By contrast, average ganglion cell inner plexiform layer thickness (GCIPLT) was substantially related to the width of the superficial VD (Both Ps=0.004). In logistic regression analysis, aging was noticeably associated with wider deep VD, whereas worse pattern standard deviation (PSD) had a significant association with wider superficial VD (Both Ps=0.001). In sum, while changes of the superficial layer seemed an overall ramification of glaucomatous damages, the deep layer was more likely to be affected by factors related to ocular microcirculation, such as IOPs and older age. Thus, looking into the deep vascular layer using OCTA could identify risk factors related to the disturbance in ocular microcirculation.

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“…The development of EDI in SD-OCT enabled clear visualization of prelaminar and laminar tissues and accelerated investigation of the relationships between these structures and glaucoma. 14 , 15 , 16 , 17 , 19 Park et al 16 pointed out a limitation; with EDI OCT, the deeper portion and posterior border of the LC lack the clarity required for precise characterization of the structure. Recently, high-penetration OCT, also known as swept-source-OCT, which uses a center wavelength of approximately 1,050 nm instead of 840 nm (the wavelength used by current SD-OCT instruments), allows the imaging of deeper ocular layers, including the choroid and LC.…”

Section: Discussionmentioning

confidence: 99%

“…Although optical coherence tomography (OCT) can visualize the anterior margins of LC and prelaminar tissue, it cannot visualize the posterior margins of the LC. It is possible to safely visualize the posterior margins of the LC and optic nerve head (ONH) with enhanced depth imaging (EDI), which is present in spectral domain (SD)-OCT. 14 , 15 , 16 , 17 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Prelaminar Region and Lamina Cribrosa with Enhanced Depth Imaging Optical Coherence Tomography in Pseudoexfoliation Glaucoma

Ersöz

Mart

Hazar

et al. 2018

tjo

Self Cite

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Objectives:To analyze optic nerve head images of pseudoexfoliative glaucoma (PXG) patients and healthy volunteers obtained with enhanced depth imaging spectral domain-optical coherence tomography (SD-OCT).Materials and Methods:Seventy patients with PXG and 68 age- and gender-matched healthy subjects were included in this prospective study. The prelaminar tissue and lamina cribrosa were imaged using spectralis OCT with the enhanced depth imaging technique. PXG disease stage was determined with visual field to evaluate relationships between prelaminar tissue thickness (PTT), lamina cribrosa thickness (LT) and disease severity.Results:There was no significant difference between the PXG group and control group with regard to age, gender, central corneal thickness, or axial length. The mean PTT (93.1±44.5 μm, p<0.05) and LT (206.3±33.6 μm p<0.05) values of the PXG group were significantly lower compared to the control group in enhanced depth imaging OCT measurements. The PXG patients were divided into stages according to visual field defect severity. While a significant difference was not detected in PTT based on disease stage (p>0.05), a statistically significant difference was detected between stages for LT (p<0.05).Conclusion:A thinner PTT was correlated with the presence of PXG but not with the severity of glaucoma. In addition, LT has a stronger relationship with disease severity and progression compared to PTT.

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The factors influencing peripapillary choroidal thickness in primary open-angle glaucoma

Abstract: In addition to previous studies, IOP and pulse rate were detected to be effective on CT. Further studies are required for determining the whole factors effective on CT and better understanding CT and glaucoma relationship.

Cited by 11 publications

References 22 publications

Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study

Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study

Determinants of Vessel Defects in Superficial and Deep Vascular Layers in Normal-Tension Glaucoma Using Optical Coherence Tomography Angiography

Evaluation of Prelaminar Region and Lamina Cribrosa with Enhanced Depth Imaging Optical Coherence Tomography in Pseudoexfoliation Glaucoma

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