The Failing Kidney Transplant Allograft. Transplant Nephrectomy: Current State-of-the-Art

Gómez-Dos-Santos, Victoria; Álvaro, J. Lorca; Hevia, Vital; Fernández-Rodríguez, Ana; Diez-Nicolás, V.; Álvarez-Rodríguez, Sara; Burgos, Jesús; Guerrero, Clara Sánchez; Burgos-Revilla, F.J.

doi:10.1007/s11934-020-0957-6

Cited by 10 publications

(8 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is well-established that GN is indicated in cases of vascular thrombosis, hyperacute rejection, and therapy resistant malignancy (183)(184)(185)(186)(187). Relative indications include severe graft pyelonephritis, the wish of withdrawal of immunosuppressants and symptoms of the intolerance syndrome (185,188,189).…”

Section: Transplantectomymentioning

confidence: 99%

“…In adults, GN is performed in about 35% of patients with a failing graft (187,190). In pediatric recipients over 50% of patients with a failing graft had GN, although data on the pediatric population are scarce (186,191).…”

Section: Transplantectomymentioning

confidence: 99%

“…This difference might be caused by the higher rates of acute rejection in children, which was thought to be caused by a more vigorous immune response in children (192). In both adults and children, recipients were most likely to have GN when graft failure occurred in the 1st year after transplantation (185)(186)(187)191).…”

Section: Transplantectomymentioning

confidence: 99%

“…Post-operative mortality rates ranged from 1 to 39% and was mostly caused by sepsis (17%). Moreover, re-transplantation outcomes are worse after GN compared to no GN (187,193,194).…”

Section: Transplantectomymentioning

confidence: 99%

“…Moreover, GN is associated with higher donor specific antibodies because of the potential absorptive capacity of the graft (195). Previous studies showed a longer interval between graft loss and re-transplantation after GN (186,187,193). Moreover, minimal residual urine and erythropoietin production from the failed graft may be preserved when immunosuppression was continued (196).…”

Section: Transplantectomymentioning

confidence: 99%

See 4 more Smart Citations

Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades

et al. 2022

View full text Add to dashboard Cite

Worldwide, over 1,300 pediatric kidney transplantations are performed every year. Since the first transplantation in 1959, healthcare has evolved dramatically. Pre-emptive transplantations with grafts from living donors have become more common. Despite a subsequent improvement in graft survival, there are still challenges to face. This study attempts to summarize how our understanding of pediatric kidney transplantation has developed and improved since its beginnings, whilst also highlighting those areas where future research should concentrate in order to help resolve as yet unanswered questions. Existing literature was compared to our own data of 411 single-center pediatric kidney transplantations between 1968 and 2020, in order to find discrepancies and allow identification of future challenges. Important issues for future care are innovations in immunosuppressive medication, improving medication adherence, careful donor selection with regard to characteristics of both donor and recipient, improvement of surgical techniques and increased attention for lower urinary tract dysfunction and voiding behavior in all patients.

show abstract

Section: Transplantectomymentioning

confidence: 99%

Section: Transplantectomymentioning

confidence: 99%

Section: Transplantectomymentioning

confidence: 99%

“…Post-operative mortality rates ranged from 1 to 39% and was mostly caused by sepsis (17%). Moreover, re-transplantation outcomes are worse after GN compared to no GN (187,193,194).…”

Section: Transplantectomymentioning

confidence: 99%