The Failure of a Prostaglandin F2a Analogue, Cloprostenol, to Initiate Lactation in Cattle

Gray, AW; Hooley, D; Fulkerson, WJ

doi:10.1071/bi9790097

Aust. Jnl. Of Bio. Sci.

1979

DOI: 10.1071/bi9790097

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The Failure of a Prostaglandin F2a Analogue, Cloprostenol, to Initiate Lactation in Cattle

AW Gray¹,

D Hooley²,

WJ Fulkerson³

Abstract: An experiment was designed to determine if the analogue of prostaglandin F2., cloprostenol, at a dose sufficient to cause luteolysis, was lactogenic in cattle.

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1986

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Artificial Induction of Lactation in Cattle: Initiation of Lactation and Estrogen and Progesterone Concentrations in Milk

Sawyer

Fulkerson²,

Martin

et al. 1986

Journal of Dairy Science

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Thirty heifers were given 11 subcutaneous injections of 5 mg estradiol benzoate and 200 mg progesterone every 3 d to develop their mammary glands. Three days later groups of animals were treated with 1) 20 mg dexamethasone twice, 2) 500 micrograms cloprostenol thrice, 3) dexamethasone and cloprostenol, 4) oxytocin 4 IU six times, or 5) no further injections. Two further groups of six heifers each (6 and 7) were treated in a manner similar to groups 1 and 3 except the dose of estrogen to develop their mammary glands was doubled to 10 mg/3 d. Six lactating first calf heifers were controls (8). The proportion of animals lactating, combined milk yield for each group (kg), and mean days lactated were 1) 5/6, 3831, 142; 2) 1/6, 912, 195; 3) 6/6, 4898, 194; 4) 3/6, 1066, 128; 5) 1/6, 293, 154; 6) 6/6, 6109, 130; 7) 6/6, 6265, 130; and 8) 6/6, 19, 190, 251. The lactogenic response to dexamethasone and oxytocin is similar to that in sheep, but the response to cloprostenol indicates a species difference. Intensive blood sampling before and after injection of hormones, intended to trigger lactogenesis, showed that plasma prolactin rose to peaks above 210 ng/ml in cows of groups 2, 3, and 4 and were unchanged from the base below 40 ng/ml in groups 1 and 5. Monitoring of steroids after induction treatment showed estradiol-17 beta ranged between 35 and 400 pg/ml and 20 to 80 pg/ml in mammary secretion and plasma and progesterone concentrations were less than at diestrus.(ABSTRACT TRUNCATED AT 250 WORDS)

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Artificial Induction of Lactation in Cattle: Initiation of Lactation and Estrogen and Progesterone Concentrations in Milk

Sawyer

Fulkerson²,

Martin

et al. 1986

Journal of Dairy Science

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show abstract

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The Failure of a Prostaglandin F2a Analogue, Cloprostenol, to Initiate Lactation in Cattle

Abstract: An experiment was designed to determine if the analogue of prostaglandin F2., cloprostenol, at a dose sufficient to cause luteolysis, was lactogenic in cattle.

Cited by 1 publication

References 8 publications

Artificial Induction of Lactation in Cattle: Initiation of Lactation and Estrogen and Progesterone Concentrations in Milk

Artificial Induction of Lactation in Cattle: Initiation of Lactation and Estrogen and Progesterone Concentrations in Milk

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