The failure of truncal vagotomy to affect motilin release in dogs

Yoshiya, Kenichi; Yamamura, Takehira; Ishikawa, Yoshihiro; Utsunomiya, Joji; Mori, Kotaro; Seino, Yutaka; Imura, Hiroo; Yanaihara, Noboru

doi:10.1016/0022-4804(85)90036-8

Cited by 16 publications

(9 citation statements)

References 5 publications

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“…While most of the GI hormones are released in response to the ingestion of a meal, motilin has the following specific characteristics: it is released at about 100-min intervals during the interdigestive state, when no nutrient is present, at least in the duodenum and the upper jejunum, and moreover the release of motilin is inhibited by feeding in dogs [30]and humans [31]. The participation of vagal control in the release of motilin has been controversial, but because chronic truncal vagotomy fails to affect motilin release [32], the release of motilin is likely to be controlled by nonvagal cholinergic innervation. In our study, the serum levels of motilin did not change during each study period.…”

Section: Discussionmentioning

confidence: 99%

Effect of Electrical Stimulation on Acupuncture Points in Diabetic Patients with Gastric Dysrhythmia: A Pilot Study

Chang

et al. 2001

Digestion

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Background/Aims: Abnormal gastric slow-wave frequencies have been observed in diabetic gastroparesis and are associated with impaired antral motor activity. In this study, we aimed at evaluating the effect of acupuncture on gastric slow waves in diabetic patients with symptoms suggesting gastric motor dysfunction. Methods: Fifteen patients with type II diabetes who had had dyspeptic symptoms for more than 3 months were enrolled. Two acupuncture needles were inserted into the subjects’ legs at the Zusanli points, and electrical stimulation (2-Hz pulses) was delivered for 30 min. Cutaneous electrogastrography was performed for 30 min at baseline, for 30 min during acupuncture, and for an additional 30 min after acupuncture. Serum gastrin, motilin, and human pancreatic polypeptide levels were also measured. Results: There was a significant increase in the percentages of normal frequency during and after acupuncture (baseline vs. acupuncture and after acupuncture 21.99 ± 19.38% vs. 45.93 ± 19.72 and 48.92 ± 19.56%; p < 0.01). In addition, the percentage of tachygastric frequency was decreased significantly during and after acupuncture. The dominant frequency was also changed significantly. There was an increase of serum human pancreatic polypeptide during acupuncture (baseline vs. acupuncture 56.96 ± 27.64 vs. 73.11 ± 22.37 pmol/l; p < 0.05). Conclusions: The results of this study revealed that electrical stimulation at the Zusanli points could increase the percentage of normal electrogastrography frequency and decrease the percentage of tachygastric frequency in diabetic patients. The data indicate that acupuncture may enhance the regularity of gastric myoelectrical activity in diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Effect of Electrical Stimulation on Acupuncture Points in Diabetic Patients with Gastric Dysrhythmia: A Pilot Study

Chang

et al. 2001

Digestion

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“…; Yoshiya et al. ; Tanaka et al. ), it has already been shown that the vagus nerve is not involved in the regulation of phase III contractions of the MMC in the study of suncus (Miyano et al.…”

Section: Discussionmentioning

confidence: 99%

Underlying mechanism of the cyclic migrating motor complex inSuncus murinus: a change in gastrointestinal pH is the key regulator

et al. 2017

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In the fasted gastrointestinal (GI) tract, a characteristic cyclical rhythmic migrating motor complex (MMC) occurs in an ultradian rhythm, at 90–120 min time intervals, in many species. However, the underlying mechanism directing this ultradian rhythmic MMC pattern is yet to be completely elucidated. Therefore, this study aimed to identify the possible causes or factors that involve in the occurrence of the fasting gastric contractions by using Suncus murinus a small model animal featuring almost the same rhythmic MMC as that found in humans and dogs. We observed that either intraduodenal infusion of saline at pH 8 evoked the strong gastric contraction or continuously lowering duodenal pH to 3‐evoked gastric phase II‐like and phase III‐like contractions, and both strong contractions were essentially abolished by the intravenous administration of MA 2029 (motilin receptor antagonist) and D‐Lys3‐GHRP6 (ghrelin receptor antagonist) in a vagus‐independent manner. Moreover, we observed that the prostaglandin E2‐alpha (PGE2‐ α) and serotonin type 4 (5HT4) receptors play important roles as intermediate molecules in changes in GI pH and motilin release. These results suggest a clear insight mechanism that change in the duodenal pH to alkaline condition is an essential factor for stimulating the endogenous release of motilin and governs the fasting MMC in a vagus‐independent manner. Finally, we believe that the changes in duodenal pH triggered by flowing gastric acid and the release of duodenal bicarbonate through the involvement of PGE2‐ α and 5HT4 receptor are the key events in the occurrence of the MMC.

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“…Electrical stimulation of the vagus results in a significant increase in the plasma motilin concentration in anesthetized dogs 19,22,23. On the other hand, others demonstrated that truncal vagotomy did not influence the intermittent fluctuation or concentration of plasma motilin in the fasting state 24. This is further supported by an acute experiment showing that the spontaneous fluctuations in the plasma motilin concentration were not influenced by vago-sympathetic nerve blockade 3.…”

Section: Questions About the Mechanism Of Gastrointestinal Migrating mentioning

confidence: 90%

Mechanism of Interdigestive Migrating Motor Complex

Takahashi

2012

J Neurogastroenterol Motil

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Migrating motor complex (MMC) is well characterized by the appearance of gastrointestinal contractions in the interdigestive state. This review article discussed the mechanism of gastrointestinal MMC. Luminal administration of 5-hydroxytryptamine (5-HT) initiates duodenal phase II followed by gastrointestinal phase III with a concomitant increase of plasma motilin release in conscious dogs. Duodenal 5-HT concentration is increased during gastric phase II and phase III. Intravenous infusion of motilin increases luminal 5-HT content and induces gastrointestinal phase III. 5-HT4 antagonists significantly inhibits both of gastric and intestinal phase III, while 5-HT3 antagonists inhibited only gastric phase III. These suggest that gastrointestinal MMC cycle is mediated via the interaction between motilin and 5-HT by the positive feedback mechanism. Gastric MMC is regulated via vagus, 5-HT3/4 receptors and motilin, while intestinal MMC is regulated via intrinsic primary afferent neurons and 5-HT4 receptors. Stress is highly associated with the pathogenesis of functional dyspepsia. Acoustic stress attenuates gastric phase III without affecting intestinal phase III in conscious dogs, via reduced vagal activity and increased sympathetic activity. It has been shown that subset of functional dyspepsia patients show reduced vagal activity and impaired gastric phase III. The physiological importance of gastric MMC is a mechanical and chemical cleansing of the empty stomach in preparation for the next meal. The impaired gastric MMC may aggravate dyspeptic symptoms following a food ingestion. Thus, maintaining gastric MMC in the interdigestive state is an important factor to prevent the postprandial dyspeptic symptoms.

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The failure of truncal vagotomy to affect motilin release in dogs

Cited by 16 publications

References 5 publications

Effect of Electrical Stimulation on Acupuncture Points in Diabetic Patients with Gastric Dysrhythmia: A Pilot Study

Effect of Electrical Stimulation on Acupuncture Points in Diabetic Patients with Gastric Dysrhythmia: A Pilot Study

Underlying mechanism of the cyclic migrating motor complex inSuncus murinus: a change in gastrointestinal pH is the key regulator

Mechanism of Interdigestive Migrating Motor Complex

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