The Family Streptomycetaceae, Part I: Taxonomy

Kämpfer, Peter

doi:10.1007/0-387-30743-5_22

Cited by 112 publications

(79 citation statements)

References 250 publications

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“…The taxonomy of Streptomyces species is particularly challenging due to the high number of species and the limited resolution of the 16S rRNA gene for species circumscription (32). This has led to the adoption of multilocus sequence analysis approaches to resolve the taxonomy of this genus (33)(34)(35).…”

Section: Resultsmentioning

confidence: 99%

Western Bats as a Reservoir of Novel Streptomyces Species with Antifungal Activity

Hamm

Caimi

Northup

et al. 2017

Appl Environ Microbiol

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At least two-thirds of commercial antibiotics today are derived from Actinobacteria, more specifically from the genus Streptomyces. Antibiotic resistance and new emerging diseases pose great challenges in the field of microbiology. Cave systems, in which actinobacteria are ubiquitous and abundant, represent new opportunities for the discovery of novel bacterial species and the study of their interactions with emergent pathogens. White-nose syndrome is an invasive bat disease caused by the fungus Pseudogymnoascus destructans, which has killed more than six million bats in the last 7 years. In this study, we isolated naturally occurring actinobacteria from white-nose syndrome (WNS)-free bats from five cave systems and surface locations in the vicinity in New Mexico and Arizona, USA. We sequenced the 16S rRNA region and tested 632 isolates from 12 different bat species using a bilayer plate method to evaluate antifungal activity. Thirty-six actinobacteria inhibited or stopped the growth of P. destructans, with 32 (88.9%) actinobacteria belonging to the genus Streptomyces. Isolates in the genera Rhodococcus, Streptosporangium, Luteipulveratus, and Nocardiopsis also showed inhibition. Twenty-five of the isolates with antifungal activity against P. destructans represent 15 novel Streptomyces spp. based on multilocus sequence analysis. Our results suggest that bats in western North America caves possess novel bacterial microbiota with the potential to inhibit P. destructans. IMPORTANCE This study reports the largest collection of actinobacteria from bats with activity against Pseudogymnoascus destructans, the fungal causative agent of white-nose syndrome. Using multigene analysis, we discovered 15 potential novel species. This research demonstrates that bats and caves may serve as a rich reservoir for novel Streptomyces species with antimicrobial bioactive compounds.KEYWORDS Actinobacteria, bats, caves, Pseudogymnoascus, Streptomyces, white-nose syndrome P resently, 90% of antibiotics are derived from microorganisms within the phylum Actinobacteria (1-3). The family Streptomycetaceae is particularly known for the production of chitinases capable of hydrolyzing the cell wall (4) and targeting ergosterol in the cell membrane of fungi (5). The rapid development of antibiotic resistance and the emergence of infectious diseases in humans and other animals, including bats and amphibians, have prompted the study of the bacterial microbiome and use for probiotic treatment in vertebrates (6, 7).

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Section: Resultsmentioning

confidence: 99%

Western Bats as a Reservoir of Novel Streptomyces Species with Antifungal Activity

Hamm

Caimi

Northup

et al. 2017

Appl Environ Microbiol

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“…Diffused melanoid pigments were sometimes observed. On YM plates colonies were irregular, flat, covered with white aerial mycelia, on ST plates colonies were elevated, and covered with white aerial mycelia and spores and on AI plates colonies were elevated and covered with grayish aerial mycelia as described by Kmpfer (2006).…”

Section: Resultsmentioning

confidence: 92%

MEDIUM OPTIMIZATION OF LIPSTATIN FROM Streptomyces toxytricini ATCC 19813 BY SHAKE FLASK STUDY

Luthra¹,

Dubey²

2012

Int J of Micr Res

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Abstract-Effect of medium composition on lipstatin production by Streptomyces toxytricini ATCC 19813 was investigated in shake flasks. The nutritional components of the medium was optimized by using Plackett-Burman, three factorial and one variable-at-a-time approach. Among the five factors studied, soya oil, soya lecithin and soya bean flour had significant effects on lipstatin production. The optimum levels of these key variables were further determined using a three factorial design and one variable-at-a-time. The highest lipstatin production was obtained in the medium consisting of glycerol 22.5 g/l, Soya flour 35 g/l, soya oil 15 g/l, soya lecithin 25 g/l and PPG 0.5 g/l at pH 7.20, 28 o C and 220 rpm. The whole optimization strategy enhanced the lipstatin production from 0.097 g/l to 0.885 g/l. Here we report 8 fold enhancements in lipstatin production following Plackett-Burman, three factorial and one variable-at-a-time approach from Streptomyces toxytricini ATCC 19813.

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“…[47]. Streptomycetaceae is a family of Actinobacteria, which constitute the monotypic suborder Streptomycineae.…”

Section: The Genus Streptomycesmentioning

confidence: 99%

A Review of the Application of Biofloccualnts in Wastewater Treatment

Agunbiade¹,

Pohl²,

Ashafa³

2016

Pol. J. Environ. Stud.

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The Family Streptomycetaceae, Part I: Taxonomy

Cited by 112 publications

References 250 publications

Western Bats as a Reservoir of Novel Streptomyces Species with Antifungal Activity

Western Bats as a Reservoir of Novel Streptomyces Species with Antifungal Activity

MEDIUM OPTIMIZATION OF LIPSTATIN FROM Streptomyces toxytricini ATCC 19813 BY SHAKE FLASK STUDY

A Review of the Application of Biofloccualnts in Wastewater Treatment

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