The famine exposure in early life and metabolic syndrome in adulthood

Wang, Ningjian; Wang, Xiaojin; Qin, Li; Han, Bing; Chen, Yi; Zhu, Chunfang; Lin, Donghui; Wang, Bingshun; Jensen, Michael D.; Lu, Yingli

doi:10.1016/j.clnu.2015.11.010

Cited by 137 publications

(115 citation statements)

References 31 publications

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“…Of these 71 articles, 24 were further excluded for various reasons (Appendix S1). Finally, 47 articles were included in the present meta‐analysis. The articles were published between 2006 and 2019, mostly published from 2014 onwards.…”

Section: Resultsmentioning

confidence: 99%

“…Foetal exposure to famine was associated with higher risks of T2DM (RR 1.37, 95% CI, 1.23‐1.52; Figure ), metabolic syndrome (RR 1.26, 95% CI, 1.07‐1.50; Figure ), hypertension (RR 1.30, 95% CI, 1.07‐1.57; Figure ), hyperglycaemia (RR 1.27, 95% CI, 1.11‐1.45; Figure ), dyslipidaemia (RR 1.48, 95% CI, 1.33‐1.66; Figure 2), obesity (RR 1.19, 95% CI, 1.02‐1.39; Figure ), overweight (RR 1.17, 95% CI, 1.07‐1.29; Figure ), coronary heart disease (RR 1.22, 95% CI, 1.00‐1.51; Figure ), and moderate‐to‐severe NAFLD (RR 1.66, 95% CI, 1.07‐2.57; Figure 3) . No association was observed for the risks of stroke (RR 1.21, 95% CI, 0.96‐1.52; Figure ) or mild NAFLD (RR 1.04, 95% CI, 0.64‐1.70; Figure 3) .…”

Section: Resultsmentioning

confidence: 99%

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Foetal and childhood exposure to famine and the risks of cardiometabolic conditions in adulthood: A systematic review and meta‐analysis of observational studies

Hidayat

Shi

et al. 2020

Obesity Reviews

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Summary A systematic review and meta‐analysis of observational studies was performed to provide a deeper understanding of the associations between foetal and childhood exposure to famine and the risks of type 2 diabetes mellitus (T2DM), metabolic syndrome, hypertension, hyperglycaemia, dyslipidaemia, obesity, overweight, coronary heart disease, stroke, and nonalcoholic fatty liver disease (NAFLD) in adulthood. Both foetal and childhood exposure to famine were positively associated with the risks of T2DM (foetal exposure: RR 1.37, 95% CI, 1.23‐1.52; childhood exposure: RR 1.33, 95% CI, 1.08‐1.64), metabolic syndrome (RR 1.26, 95% CI, 1.07‐1.50; RR 1.24, 95% CI, 1.13‐1.35), hypertension (RR 1.30, 95% CI, 1.07‐1.57; RR 1.33, 95% CI, 1.02‐1.74), hyperglycaemia (RR 1.27, 95% CI, 1.11‐1.45; RR 1.25, 95% CI, 1.10‐1.42), dyslipidaemia (RR 1.48, 95% CI, 1.33‐1.66; RR 1.27, 95% CI, 1.12‐1.45), obesity (RR 1.19, 95% CI, 1.02‐1.39; RR 1.13, 95% CI, 1.00‐1.28), overweight (RR 1.17, 95% CI, 1.07‐1.29; RR 1.07, 95% CI, 1.00‐1.14), coronary heart disease (RR 1.22, 95% CI, 1.00‐1.51; RR 1.21, 95% CI, 1.09‐1.35), and moderate‐to‐severe NAFLD (RR 1.66, 95% CI, 1.07‐2.57; RR 1.68, 95% CI, 1.41‐1.99) in adulthood. No association was observed for the risks of stroke or mild NAFLD. Adjustments for age, alcohol, smoking, body mass index, and physical activity nullified some associations. The associations were generally stronger in women than in men. In summary, foetal and childhood exposure to famine may confer greater risks of developing certain cardiometabolic conditions in adulthood, particularly in women. The extent to which risks for cardiometabolic conditions are associated with early‐life famine appears to be determined by certain factors in adulthood.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Foetal and childhood exposure to famine and the risks of cardiometabolic conditions in adulthood: A systematic review and meta‐analysis of observational studies

Hidayat

Shi

et al. 2020

Obesity Reviews

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“…Several studies on the association between the Great Chinese Famine and the risk of T2DM or metabolic syndrome have been published . Unfortunately, few studies were conducted nationwide.…”

Section: Introductionmentioning

confidence: 99%

Association between famine exposure in early life and type 2 diabetes mellitus and hyperglycemia in adulthood: Results from the China Health And Retirement Longitudinal Study (CHARLS)

Sun

Zhang

Duan

et al. 2018

Journal of Diabetes

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For females, the risk of hyperglycemia was higher for famine-exposed than not exposed cohort (odds ratios [OR] 1.34 and 95% confidence intervals [CIs]: 1.34 [1.04-1.74], 1.48 [1.15-1.90], 1.38 [1.06-1.79], and 1.57 [1.25-1.98] for fetal, early, middle, and late childhood exposure, respectively), and this association was even stronger in female participants who lived in rural areas before the age of 16 years. In males, the risk of T2DM was lower for the early and late childhood exposure than no exposure cohorts (OR [95% CIs]: 0.65 [0.49-0.86] and 0.74 [0.56-0.98], respectively). [Correction added on 23 July 2018, after first online publication: Parts of the above 'Results' section have been corrected to interchange the citation of the words 'late' and 'early'.] CONCLUSION: Exposure to famine during early life can increase the risk of hyperglycemia in female adults, but may decrease the risk of T2DM in males.

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“…Body mass index (BMI) was calculated as weight in kilograms divided by height in meters squared. Each of the 16 study sites was categorized as having a high or low economic status in comparison with the GDP per capita of the whole nation (6,807 US dollars, based on a World Bank estimate) in 2013 [10] .…”

Section: Clinical and Anthropometric Measurementsmentioning

confidence: 99%

Hypothalamic-Pituitary-Gonadal Axis in Aging Men and Women: Increasing Total Testosterone in Aging Men

Xia

Wang²,

Han³

et al. 2016

Neuroendocrinology

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Background: Aging is associated with variations in hypothalamic-pituitary-gonadal (HPG) axis hormones. However, it is not clear how aging changes these hormones. This study examined the natural alterations in the HPG axis in aging men and women in China. Methods: Data were obtained from our cross-sectional study (SPECT-China) in 16 areas of three provinces in East China between February and June 2014. There were 6,825 subjects selected, including 2,908 men and 3,917 women aged 25-93 years who had no diseases affecting HPG hormones and did not take exogenous supplements. Total testosterone (TT), estradiol (E2), free testosterone, sex hormone-binding globulin (SHBG), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were measured. Results: In men, the ranges of the 10-90th percentiles for each hormone were as follows: TT, 9.9-23.4 nmol/l; SHBG, 20.6-79.54 nmol/l; E2, 34.84-187 pmol/l. TT values were higher in men aged 25-30 years than in those aged 31-35 years and began to increase progressively at the age of 41-50 years until men reached their eighties. The unadjusted annual age trend (β) was 0.079 nmol/l/year (p < 0.001). A linear regression analysis, after full adjustment for demographic variables, metabolic factors, other hormones, lifestyle and co-morbidities, showed that higher TT levels were still associated with aging (p < 0.05). However, the ratio of TT to LH decreased with age (β = -0.272/year, p < 0.001). E2 and SHBG increased with age (β = 1.774 pmol/l/year and 1.118 nmol/l/year, respectively, p < 0.001). In women, the 10-90th percentile range of E2 was 32.79-565.8 pmol/l. E2 began to decrease at the age of 46-50 years, declined sharply at the age of 51-55 years (β = -5.73 pmol/l/year, p < 0.001) and then stabilized at a low concentration after the age of 55 years. The 10-90th percentile ranges of LH and FSH in men were 2.4-9.2 and 3.4-15.5 IU/l, and in women they were 3-36.6 and 4-89.28 IU/l, respectively. FSH increased by 7.11% per annum in men and by 12.76% per annum in women, but LH increased by only approximately 4.00% per annum in both sexes. Conclusions: The influence of aging on the HPG axis is sex dependent. The pattern of age-related TT was different in Chinese Han men when compared with previous studies in Western populations. TT values increased in aging men, so it is not suitable to estimate the life quality of older Chinese men just based on TT.

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The famine exposure in early life and metabolic syndrome in adulthood

Abstract: Exposure to famine in early life had sex-specific association with MS. It also suggests the adverse effects of malnutrition might extend beyond the 'first 1000 days' and last 9 years.

Cited by 137 publications

References 31 publications

Foetal and childhood exposure to famine and the risks of cardiometabolic conditions in adulthood: A systematic review and meta‐analysis of observational studies

Foetal and childhood exposure to famine and the risks of cardiometabolic conditions in adulthood: A systematic review and meta‐analysis of observational studies

Association between famine exposure in early life and type 2 diabetes mellitus and hyperglycemia in adulthood: Results from the China Health And Retirement Longitudinal Study (CHARLS)

Hypothalamic-Pituitary-Gonadal Axis in Aging Men and Women: Increasing Total Testosterone in Aging Men

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