The fat body of the cheek: a modern view of the problem

Zhidkov, R.A.; Tsitsiashvili, A.M.; Vasil’ev, Yu.L.; Panin, A.M.; Darawsheh, H.M.; Fakhrislamova, L.R.

doi:10.17116/operhirurg2022604152

Cited by 1 publication

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“…The buccal fat pad is represented by a paired encapsulated fat formation. On the one hand, it has biological implementation at different ages of the patient, and on the other hand, it can be used in small and large reconstructive surgical procedures, especially in the maxillofacial region [3]. These include the repair of oral cavity defects after resective surgeries, closure of clefts of the hard and soft palate, treatment of peri-implantitis and repair of defects around dental implants, and the management of tooth recessions and OAC [4], as well as in the treatment of temporomandibular joint ankylosis [5][6][7][8][9], congenital pathologies, jawbone necrosis, and postoperative reconstructions in cancer patients [10].…”

Section: Introductionmentioning

confidence: 99%

Morphological Evaluation and Immunohistochemical Analysis of the Reparative Potential of the Buccal Fat Pad

Zhidkov,

Panin,

Drobyshev

et al. 2024

Medicina

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Background and Objectives: There are many surgical techniques for oroantral communication treatment, one of which is the buccal fat pad. Of particular interest is the high reparative potential of the buccal fat pad, which may be contributed to by the presence of mesenchymal stem cells. The purpose of this work is to evaluate the reparative potential of BFP cells using morphological and immunohistochemical examination. Materials and Methods: 30 BFP samples were provided by the Clinic of Maxillofacial and Plastic Surgery of the Russian University of Medicine (Moscow, Russia) from 28 patients. Morphological examination of 30 BFP samples was performed at the Institute of Clinical Morphology and Digital Pathology of Sechenov University. Hematoxylin–eosin, Masson trichrome staining and immunohistochemical examination were performed to detect MSCs using primary antibodies CD133, CD44 and CD10. Results: During staining with hematoxylin–eosin and Masson’s trichrome, we detected adipocytes of white adipose tissue united into lobules separated by connective tissue layers, a large number of vessels of different calibers, as well as the general capsule of BFP. The thin connective tissue layers contained neurovascular bundles. Statistical processing of the results of the IHC examination of the samples using the Mann–Whitney criterion revealed that the total number of samples in which the expression of CD44, CD10 and CD133 antigens was confirmed was statistically significantly higher than the number of samples where the expression was not detected (p < 0.05). Conclusions: During the morphological study of the BFP samples, we revealed statistically significant signs of MSCs presence (p < 0.05), including in the brown fat tissue, which proves the high reparative potential of this type of tissue and can make the BFP a choice option among other autogenous donor materials when eliminating OAC and other surgical interventions in the maxillofacial region.

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