The Fat Halo Sign

Ahualli, Jorge

doi:10.1148/radiol.2423041600

Cited by 43 publications

(25 citation statements)

References 10 publications

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“…It can be differentiated from true lipoma which appears as an asymmetric mass, whereas lipomatosis manifests as a symmetric enlargement 2 8. Chronic inflammatory bowel diseases (Crohn's disease and ulcerative colitis) may cause a similar appearance called a ‘fat halo sign’ in which fatty infiltration of the submucosa is present 9. This sign is mostly seen in patients with a longer disease duration 10.…”

Section: Discussionmentioning

confidence: 99%

Lipomatosis of the terminal ileum and ileocaecal valve: multidetector CT findings

et al. 2013

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Intestinal lipomatosis, also known as lipohyperplasia, is a rare disease. Diffuse infiltration of fatty tissue mainly in the submucosal layer is characteristic. It is usually asymptomatic and found incidentally. We report a case of lipomatosis in the terminal ileum and ileocaecal valve. Multidetector CT with contrast enhancement showed fatty infiltration of the terminal ileum and ileocaecal valve.

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Section: Discussionmentioning

confidence: 99%

Lipomatosis of the terminal ileum and ileocaecal valve: multidetector CT findings

et al. 2013

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“…In patients with Crohn's disease mesenteric adipose tissue hypertrophy is a characteristic feature of this disease [3] whereas submucosal fat deposition (fat halo sign) is known in CD and UC [4]. Adiponectin is an adipose tissue-derived protein with protective effects in diseases associated with low grades of chronic inflammation like type 2 diabetes or atherosclerosis [5,6].…”

Section: Introductionmentioning

confidence: 99%

Circulating levels of chemerin and adiponectin are higher in ulcerative colitis and chemerin is elevated in Crohnʼs disease

Weigert

Obermeier

Neumeier

et al. 2010

Inflammatory Bowel Diseases

143

111

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Serum collection and IBD biobank supported by the Bundesministerium für Bildung und Forschung (German Ministry of Education and Research), Kompetenznetz chronisch entzündliche Darmerkrankungen (Competence network "Inflammatory Bowel Disease"). AbstractChemerin is an adipose tissue-secreted protein that stimulates chemotaxis of cells of the innate immune system. Inflammatory bowel disease (IBD) is linked to an impaired immune response and, therefore, we hypothesized that systemic chemerin may be altered in IBDpatients. Serum was collected from patients with Crohn´s disease (CD, 230 patients), ulcerative colitis (UC, 80 patients) and healthy controls (HC, 80 probands). Chemerin and adiponectin, which has already been measured in the serum of similar cohorts by others, were determined by ELISA. Sytemic chemerin concentrations were significantly elevated in serum of CD and UC patients compared to HC, and were also found to be higher in the serum of males with CD compared to males with UC. Adiponectin levels were lower in CD compared to UC and HC with similar circulating concentrations. In serum of male but not female patients chemerin levels were higher in UC patients with active disease whereas adiponectin was reduced. In CD elevated chemerin was associated with remission in males only.Treatment with corticosteroids was linked to elevated adiponectin in male CD patients and higher chemerin in female UC patients. Unlike adiponectin that is elevated in female serum in all cohorts analysed, chemerin was only higher in the serum of female UC patients.These data indicate that the levels of circulating chemerin are elevated in patients suffering from UC and CD whereas adiponectin is reduced in the latter. Relations of the systemic 2 concentrations of these adipokines to disease activity and treatment are disease-and genderspecific.3

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“…MBCT imaging for Crohn’s disease can delineate extraluminal complications such as fluid collections and enterocutaneous/enteroenteric fistulas. MBCT can also identify widening and fatty infiltration of the submucosal layer of the bowel due to chronic inflammation, consistent with the fat-halo sign [15]. Extra-enteric abnormalities associated with Crohn’s disease, including gallstones, renal stones and sacroiliitis, can often be identified.…”

Section: Discussionmentioning

confidence: 99%

Modified small bowel CT (MBCT) for evaluating sub-acute and chronic conditions affecting the small bowel: a low radiation-dose, unenhanced CT protocol

2011

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The Fat Halo Sign

Cited by 43 publications

References 10 publications

Lipomatosis of the terminal ileum and ileocaecal valve: multidetector CT findings

Lipomatosis of the terminal ileum and ileocaecal valve: multidetector CT findings

Circulating levels of chemerin and adiponectin are higher in ulcerative colitis and chemerin is elevated in Crohnʼs disease

Modified small bowel CT (MBCT) for evaluating sub-acute and chronic conditions affecting the small bowel: a low radiation-dose, unenhanced CT protocol

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