The fate and function of oligodendrocyte progenitor cells after traumatic spinal cord injury

Duncan, Greg J.; Manesh, Sohrab B.; Hilton, Brett J.; Assinck, Peggy; Plemel, Jason R.; Tetzlaff, Wolfram

doi:10.1002/glia.23706

Cited by 81 publications

(71 citation statements)

References 239 publications

(416 reference statements)

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“…Failure of recruitment of OPCs to the SCI lesion site is associated with the inability of axon remyelination and sensitivity to degeneration (Irvine & Blakemore, 2008). Promoting the recruitment and differentiation of OPCs to the lesion site can is a lesser-explored avenue (Duncan et al, 2019). Various growth factors and hormones can stimulate the differentiation of OPCs in vitro but their in vivo efficacy is unclear (Plemel et al, 2014).…”

Section: Remyelinationmentioning

confidence: 99%

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

2020

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The recent years saw the advent of promising preclinical strategies that combat the devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials. However, individually, these treatments produce only modest levels of recovery in animal models of SCI that could hamper their implementation into therapeutic strategies in spinal cord injured humans. Combinational strategies have demonstrated greater beneficial outcomes than their individual components alone by addressing multiple aspects of SCI pathology. Clinical trial designs in the future will eventually also need to align with this notion. The scenario will become increasingly complex as this happens and conversations between basic researchers and clinicians are required to ensure accurate study designs and functional readouts.

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Section: Remyelinationmentioning

confidence: 99%

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

2020

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“…Reactive microglia also produce many cytotoxic components that are responsible for the eradication of local oligodendrocytes [58]. Oligodendrocyte precursor cells (OPCs) respond to this by migrating to the lesion then proliferating and differentiating, which further forms a structurally layered glial scar and helps stabilize dystrophic axons within the hostile lesion environment [59,60]. Overall, peripheral axons regenerate more readily than central nervous system axons, and many experts attribute this difference to the Schwann cell response to injury.…”

Section: Healthy and Pathological Glial Activitymentioning

confidence: 99%

“…After CNS injury, oligodendrocyte populations are vital in remyelinating regenerating axons and improving their conduction velocities, a crucial component of restoring sensory and motor function [59]; thus, it is important to understand how various characteristics of electrospun fibers affect the ability of oligodendrocytes to remyelinate postinjury. Although the effects of electrospun fiber orientation have been readily investigated with other glia, such as Schwann cells and astrocytes, only one study has investigated the effect of fiber orientation on OPCs.…”

Section: Oligodendroglia Response To Electrospun Fibers In Vitromentioning

confidence: 99%

Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration

et al. 2020

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Electrospinning is a fabrication technique used to produce nano- or micro- diameter fibers to generate biocompatible, biodegradable scaffolds for tissue engineering applications. Electrospun fiber scaffolds are advantageous for neural regeneration because they mimic the structure of the nervous system extracellular matrix and provide contact guidance for regenerating axons. Glia are non-neuronal regulatory cells that maintain homeostasis in the healthy nervous system and regulate regeneration in the injured nervous system. Electrospun fiber scaffolds offer a wide range of characteristics, such as fiber alignment, diameter, surface nanotopography, and surface chemistry that can be engineered to achieve a desired glial cell response to injury. Further, electrospun fibers can be loaded with drugs, nucleic acids, or proteins to provide the local, sustained release of such therapeutics to alter glial cell phenotype to better support regeneration. This review provides the first comprehensive overview of how electrospun fiber alignment, diameter, surface nanotopography, surface functionalization, and therapeutic delivery affect Schwann cells in the peripheral nervous system and astrocytes, oligodendrocytes, and microglia in the central nervous system both in vitro and in vivo. The information presented can be used to design and optimize electrospun fiber scaffolds to target glial cell response to mitigate nervous system injury and improve regeneration.

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“…Moreover, oligodendrocytes precursor cells change their gene expression following CNS damage, starting to express cytokines, and perpetuating the immune response. On the other hand, oligodendrocyte progenitor cells participate in the resolution of the scar, limiting the extent of neurotoxic inflammatory lesion core cells ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

Fibrotic Scar in Neurodegenerative Diseases

D’Ambrosi

Apolloni

2020

Front. Immunol.

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The process of uncontrolled internal scarring, called fibrosis, is now emerging as a pathological feature shared by both peripheral and central nervous system diseases. In the CNS, damaged neurons are not replaced by tissue regeneration, and scar-forming cells such as endothelial cells, inflammatory immune cells, stromal fibroblasts, and astrocytes can persist chronically in brain and spinal cord lesions. Although this process was extensively described in acute CNS damages, novel evidence indicates the involvement of a fibrotic reaction in chronic CNS injuries as those occurring during neurodegenerative diseases, where inflammation and fibrosis fuel degeneration. In this mini review, we discuss recent advances around the role of fibrotic scar formation and function in different neurodegenerative conditions, particularly focusing on the rising role of scarring in the pathogenesis of amyotrophic lateral sclerosis, multiple sclerosis, and Alzheimer's disease and highlighting the therapeutic relevance of targeting fibrotic scarring to slow and reverse neurodegeneration.

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The fate and function of oligodendrocyte progenitor cells after traumatic spinal cord injury

Cited by 81 publications

References 239 publications

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration

Fibrotic Scar in Neurodegenerative Diseases

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