The fate of acutely inflamed joints with a negative synovial fluid culture

Hujazi, Ihab; Oni, D. B.; Arora, Arvind; Muniz, Garciela; Khanduja, Vikas

doi:10.1007/s00264-012-1503-z

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…Its use in synovial fluid has been claimed to be highly specific, although sensitivity is only 40 to 45%. 17 In our study too, Gram staining did not offer great sensitivity and correlated well with culture in only 35.71%. Apart from the diagnostic challenges, the management of these patients is a far more challenging issue, with scanty literature on the subject.…”

Section: Discussioncontrasting

confidence: 50%

A Prospective Study to Assess the Optimal Incubation Times for Culture and Aerobic Bacterial Profile in Prosthetic Joint Infections

et al. 2021

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Introduction With an increase in the number of total joint arthroplasties, the count of prosthetic joint infections (PJIs) is also increasing and has become a nightmare for an orthopaedic surgeon. Microbiological diagnosis is important for administering definitive antimicrobial treatment. Negative culture reports hamper patient management and prolonged incubation periods have increased the culture yield but at the risk of culture contamination in conventional microbiology settings. Thus, we aimed to optimize the best incubation time for culture and the aerobic bacterial profile of PJIs. Material and Methods Over a year, samples from clinically suspected PJI patients were collected and processed for culture using standard techniques. The samples were incubated for up to 10 days with daily subculturing on to solid media. The bacterial isolates were identified and antibiotic susceptibility was performed. Results Out of 200 patients, 105 were included in the study and samples were collected in triplicate. In 70 cases culture was positive and 35 were culture negative PJIs. Mean incubation days to culture positivity was 3.6 days with 97.14% culture positivity seen by the seventh day of incubation. Twenty-four percent methicillin-resistant Staphylococcus aureus, and more than 50% extended spectrum β lactamase producing Klebsiella pneumoniae and Escherichia coli were isolated. Discussion Culture positivity in PJIs provides definitive evidence of infection and guides the treatment. Increasing the incubation times can help in maximizing the culture yield, and we found that 97.14% pathogens grew within 7 days of incubation. Prolonging it further would not provide an added advantage especially in a resource-constraint setting.

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Section: Discussioncontrasting

confidence: 50%

A Prospective Study to Assess the Optimal Incubation Times for Culture and Aerobic Bacterial Profile in Prosthetic Joint Infections

et al. 2021

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“…Although the culture of the synovial aspirate was negative, septic arthritis could not be excluded given the fact that up to 48% of septic arthritis cases are culture negative. 13 Of note, although the patient's blood culture was negative, the culture was drawn after systemic antibiotic therapy was administered. Atypical presentation of reactive arthritis may be also a possibility in our patient given the history of urethritis and presumed reactive arthritis.…”

Section: Discussionmentioning

confidence: 99%

Endogenous endophthalmitis caused by Staphylococcus capitis

Elhusseiny

Shamim

Sanders

et al. 2022

American Journal of Ophthalmology Case Reports

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“…The most common causative agent in all ages is Staphylococcus aureus in almost half of the cases 6 . However, it has been stated that the pathogen cannot be identified in almost 40% of cases 7 , this scenario has been associated with a longer hospital stay and increased mortality 8 . Rapid identification of the infected joint is essential for preserving joint function and to avoid a wide number of complications related to the disease.…”

Section: Introductionmentioning

confidence: 99%

Glucose and leukocyte esterase levels are possible biomarkers for bacterial septic arthritis

Gonzalez-Chapa,

Peña-Martínez,

Gonzalez

et al. 2024

CIRUE

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Objective:The objective of the study was to determine the added value of synovial fluid (SF) glucose levels and other biochemical parameters as possible biomarkers of bacterial septic arthritis (SA). Materials and methods: We prospectively examined adult patients with SA. As a control group, adults with uninfected joints were enrolled. SF samples were obtained, and microbiological analyses were made. SF glucose levels, pH, and leukocyte esterase were measured using a glucometer and colorimetric test strips. Blood samples were collected from both groups to determine glucose levels. Results: We included eight subjects with knee ligaments lesions, six with meniscus lesions, and five with osteoarthritis as the control group, as well as 20 patients with SA. SF culture was positive in 60%. SF glucose levels from patients were lower than the controls (p = 0.0018) with the lowest concentration in patients with a positive culture (p = 0.0004). Blood and SF glucose concentration from the positive culture patients were compared (p < 0.0001). Leukocyte esterase presented the highest values in patients with a positive culture (p < 0.0001) and a more acidic pH was found compared to the control group (p < 0.0001). Conclusion: These biochemical parameters might be a quick and inexpensive added value for distinguishing between infective and non-infective joint disease.

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The fate of acutely inflamed joints with a negative synovial fluid culture

Cited by 8 publications

References 25 publications

A Prospective Study to Assess the Optimal Incubation Times for Culture and Aerobic Bacterial Profile in Prosthetic Joint Infections

A Prospective Study to Assess the Optimal Incubation Times for Culture and Aerobic Bacterial Profile in Prosthetic Joint Infections

Endogenous endophthalmitis caused by Staphylococcus capitis

Glucose and leukocyte esterase levels are possible biomarkers for bacterial septic arthritis

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