The Fate of Cadaver Renal Allografts Contaminated Before Transplantation

Mccoy, Guy C.; Loening, Stefan A.; Braun, William E.; Magnusson, Magnus O.; Banowsky, Lynn H.; McHenry, Martin C.

doi:10.1097/00007890-197512000-00004

Cited by 54 publications

(25 citation statements)

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“…Given the poor outcomes associated with Candida arteritis, systematic nephrectomy has been suggested in cases in which graft preservation solution samples have positive culture results for Candida species [9]. However, in 1990, the overall rate of positive preservation solution culture results ranged from 5%-23%, with fungi represented in 2%-10% of all positive cultures [37][38][39][40][41][42]. Recently, the systematic culture of the preservation solutions for at least 5 days at 30ЊC established a 3.6% incidence of positive culture results for preservation solutions without subsequent consequence for the transplant recipients who empirically received antifungal treatment [43].…”

Section: Discussionmentioning

confidence: 99%

Evidence That Graft‐Site Candidiasis after Kidney Transplantation Is Acquired during Organ Recovery: A Multicenter Study in France

Albano¹,

Bretagne²,

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Evidence That Graft‐Site Candidiasis after Kidney Transplantation Is Acquired during Organ Recovery: A Multicenter Study in France

Albano¹,

Bretagne²,

et al. 2009

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“…7 In solid organ transplants, infectious processes are responsible for the majority of graft losses despite new immunosuppression protocols and efforts to identify infectious agents in both the donor and the recipient. [8][9][10] Prospective studies have reported mortality rates after transplants around 50% in the case of invasive fungal processes and up to 30% in the case of bacterial infections. 11 Up to 75% of transplanted patients will present some infectious process in the first year after transplant.…”

Section: Methodsmentioning

confidence: 99%

“…These microbes are of low virulence and rarely cause a significant infectious process. 4,8 The high incidence of these agents allows us to propose that their origin may be from breach of aseptic techniques during collection. 4 However, there is a possibility of contamination of the preservation solution with organisms of high virulence and multidrug resistance.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the presence of microorganisms in solid-organ preservation solution

Mattana

Marra

Machado³

et al. 2011

Braz J Infect Dis

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Objective: To assess the presence of microorganism contamination in the preservation solution for transplant organs (kidney/pancreas). Method: Between August 2007 and March 2008, 136 samples of preservation solution were studied prior to graft implantation. Variables related to the donor and to the presence of microorganisms in the preservation solution of organs were evaluated, after which the contamination was evaluated in relation to the "recipient culture" variable. Univariate and multivariate statistical analyses were performed. Results: The contamination rate of the preservation solution was 27.9%. Coagulase-negative Staphylococcus was the most frequently isolated microorganism. However, highly virulent agents, such as fungi and enterobacteria, were also isolated. In univariate analysis, the variable "donor antibiotic use" was significantly associated to the contamination of the preservation solution. On the other hand, multivariate analysis found statistical significance in "donor antibiotic use" and "donor's infectious complications" variables. Conclusions: In this study, 27.9% of the preservation solutions of transplant organs were contaminated. Infectious diseases and non-use of antibiotics by the donor were significantly related to the presence of microorganisms in organ preservation solutions. Contamination in organ preservation solutions was not associated with infection in the recipient.

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“…The transmission of various infectious agents along with the transplanted kidney has been described; they include Staphylococcus aureus [1], gram-negative organ isms [2], Candida albicans [3], Histoplasma capsulatum [4], Cryptococcus neoformans [5], and cytomegalovirus (CMV) [6,7]. The allografts may be contaminated in the potential cadaver donor, before or during the procure ment process; they also may be contaminated by cold electrolyte solution or the perfusate during the preserva tion period [8,9]: finally, latent and asymptomatic infec tions can be reactivated when host susceptibility to infec tion is increased by immunosuppressive therapy [6,7], In this report we describe 2 cadaver kidney recipients who received allografts procured on the same donor and subsequently developed disseminated mycobacterial in fection.…”

Section: Introductionmentioning

confidence: 99%

Transmission of <i>Mycobacterium tuberculosis</i> with Renal Allografts

Mourad

Soulillou

Chong

et al. 1985

Nephron

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Disseminated tuberculosis occurred in 2 allograft recipients of kidneys procured on the same donor. Both recipients were treated by low dose prednisolone and azathioprine, and one of them was on a special protocol including antilymphocyte globulins as rejection prophylaxis. None of them experienced acute rejection. The early posttransplant period was uneventful except for the occurrence of mild viral infections in both cases (herpes simplex virus in case 1 and cytomegalovirus in case 2). 2 and 6 months after transplantation, respectively, patient 1 developed acute fever, asthenia, and disorientation while patient 2 presented with spiking fever and miliary pneumonitis. Mycobacterium tuberculosis grew in the urine of both recipients in the absence of clinical genitourinary symptoms. The two mycobacterial species had the same bacteriologic characteristics and the same antibiotic sensitivity. As the recipients had no evidence of a previous history of active tuberculosis, it is suggested, as for some other infectious agents, that mycobacterium was transmitted along with the transplanted kidneys.

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The Fate of Cadaver Renal Allografts Contaminated Before Transplantation

Cited by 54 publications

References 0 publications

Evidence That Graft‐Site Candidiasis after Kidney Transplantation Is Acquired during Organ Recovery: A Multicenter Study in France

Evidence That Graft‐Site Candidiasis after Kidney Transplantation Is Acquired during Organ Recovery: A Multicenter Study in France

Evaluation of the presence of microorganisms in solid-organ preservation solution

Transmission of <i>Mycobacterium tuberculosis</i> with Renal Allografts

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