The fate of erythromycin in soils and its effect on soil microbial community structure

Shen, Dahang; Gu, Xiaoxiong; Zheng, Yaoying; Delgado-Moreno, Laura; Jia, Weibin; Ye, Qingfu; Wang, Wei

doi:10.1016/j.scitotenv.2022.153373

Cited by 14 publications

(5 citation statements)

References 37 publications

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“…This study identified the presence of seven antibiotics belonging to four distinct classes, namely sulfonamides (SDZ, TMP), quinolones and fluoroquinolones (CIP, OFL), tetracyclines (TC, OTC) and cephalosporins (CEF), within the soil samples analyzed. None of the soil samples collected exhibited the presence of macrolides (ERY), which could potentially be attributed to their rapid degradation by soil microorganisms, as previously elucidated (Shen et al 2022). The results of the study indicated that oxytetracycline was present in the soil at the highest concentration, ranging from 1.58 to 14.42 ± 1.32 μg kg −1 , across all soil types.…”

Section: Heavy Metals In Agriultural Soilsmentioning

confidence: 61%

Occurrence and distribution of antibiotics and antibiotic resistance genes in the different croplands along the Yellow River shoreline

Zhang

Yuan

2023

Environ. Res. Commun.

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Many antibiotics and their related antibiotic resistance genes (ARGs) are found in agricultural soil, raising concerns for public and environmental health. As a result, it is crucial to examine the abundance of sulfonamides, fluoroquinolones, tetracyclines, macrolides, and β-lactam antibiotics and their corresponding ARGs in agricultural soils. We investigated the abundance of aadA, sul1, aac(6')-Ib, tetX, tetA, ermB, mphB, qnrA, intI1, intI2, and ISCR1 genes and explore their relationships with antibiotics in rice, peach orchard, maize, peanut, and garlic croplands along the Yellow River in Zhongmu and Yuanyang, Henan Province. There was no significant difference across the five croplands (P > 0.05), however, the paddy field had the highest average concentration (> 10 µg/kg) of oxytetracycline, tetracycline, ciprofloxacin, and norfloxacin antibiotics. The predominant ARGs were aadA, sul1, with the highest number of ARGs and MGEs detected in paddy rice, followed by maize, peanut, garlic, and peach soils. Integrase gene intI1 was significantly greater than intI2 and ISCR1, which was positively linked with sul1, aadA, aac(6')-Ib, tetA, tetX, and ermB genes (P < 0.05). According to redundancy analysis, antibiotics may accelerated the prevalence of ARGs. Redundancy analysis demonstrated that antibiotics contributed 78.7% of the total ARG variations. Notably, the concentration of oxytetracycline in all the croplands ranged from 10.33 to 14.42 µg/kg, which had impacted the frequency of ermB, blaCTX-M, intI2, and mphB genes as demonstrated by RDA analysis. Results revealed that effective techniques are required to lower ARG prevalence in agroecosystems.

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Section: Heavy Metals In Agriultural Soilsmentioning

confidence: 61%

Occurrence and distribution of antibiotics and antibiotic resistance genes in the different croplands along the Yellow River shoreline

Zhang

Yuan

2023

Environ. Res. Commun.

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“…The direct correlation between antimicrobial residues and AMR in the environment is difficult to predict because antimicrobial residues can impose additive and co-selective pressure. A recent study showed that an erythromycin concentration of 2.5 mg/Kg in soil was capable of changing the microbial diversity [ 53 ]. This concentration is still much higher than that found in farms in this study.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Residue Accumulation Contributes to Higher Levels of Rhodococcus equi Carrying Resistance Genes in the Environment of Horse-Breeding Farms

Higgins,

Cohen,

Slovis

et al. 2024

Veterinary Sciences

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Antimicrobial residues excreted in the environment following antimicrobial treatment enhance resistant microbial communities in the environment and have long-term effects on the selection and maintenance of antimicrobial resistance genes (AMRGs). In this study, we focused on understanding the impact of antimicrobial use on antimicrobial residue pollution and antimicrobial resistance (AMR) in the environment of horse-breeding farms. Rhodococcus equi is an ideal microbe to study these associations because it lives naturally in the soil, exchanges AMRGs with other bacteria in the environment, and can cause disease in animals and humans. The environment is the main source of R. equi infections in foals; therefore, higher levels of multidrug-resistant (MDR) R. equi in the environment contribute to clinical infections with MDR R. equi. We found that macrolide residues in the environment of horse-breeding farms and the use of thoracic ultrasonographic screening (TUS) for early detection of subclinically affected foals with R. equi infections were strongly associated with the presence of R. equi carrying AMRGs in the soil. Our findings indicate that the use of TUS contributed to historically higher antimicrobial use in foals, leading to the accumulation of antimicrobial residues in the environment and enhancing MDR R. equi.

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“…The results showed that macrolide and sulfonamide antibiotics significantly influenced the microbial community structure, although their residual concentrations in the vegetable soils were substantially low, which is consistent with the results of previous studies conducted on aquaculture sediment and farmland soils in natural settings [ 9 , 10 , 61 ]. Macrolide antibiotics, which have broad-spectrum activity against many Gram-positive bacteria, can significantly decrease microbial diversity [ 62 ]. The strong correlation observed between the presence of macrolide antibiotics and certain bacterial phyla (e.g., Proteobacteria , Acidobacteria , Actinobacteria , Firmicutes , and Chloroflexi ) in this study may be due to potential macrolide-resistant bacteria using macrolides as carbon and energy sources.…”

Section: Discussionmentioning

confidence: 99%

Adaptation of Rhizosphere Microbial Communities to Continuous Exposure to Multiple Residual Antibiotics in Vegetable Farms

Qiu

Chen

Feng

et al. 2023

IJERPH

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The constant application of manure-based fertilizers in vegetable farms leads to antibiotic residue accumulation in soils, which has become a major stressor affecting agroecosystem stability. The present study investigated the adaptation profiles of rhizosphere microbial communities in different vegetable farms to multiple residual antibiotics. Multiple antibiotics, including trimethoprim, sulfonamides, quinolones, tetracyclines, macrolides, lincomycins, and chloramphenicols, were detected in the vegetable farms; the dominant antibiotic (trimethoprim) had a maximum concentration of 36.7 ng/g. Quinolones and tetracyclines were the most prevalent antibiotics in the vegetable farms. The five most abundant phyla in soil samples were Proteobacteria, Actinobacteria, Acidobacteria, Chloroflexi and Firmicutes, while the five most abundant phyla in root samples were Proteobacteria, Actinobacteria, Bacteroidetes, Firmicutes and Myxococcota. Macrolides were significantly correlated with microbial community composition changes in soil samples, while sulfonamides were significantly correlated with microbial community composition changes in root samples. Soil properties (total carbon and nitrogen contents and pH) influenced the shifts in microbial communities in rhizosphere soils and roots. This study provides evidence that low residual antibiotic levels in vegetable farms can shift microbial community structures, potentially affecting agroecosystem stability. However, the degree to which the shift occurs could be regulated by environmental factors, such as soil nutrient conditions.

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The fate of erythromycin in soils and its effect on soil microbial community structure

Cited by 14 publications

References 37 publications

Occurrence and distribution of antibiotics and antibiotic resistance genes in the different croplands along the Yellow River shoreline

Occurrence and distribution of antibiotics and antibiotic resistance genes in the different croplands along the Yellow River shoreline

Antimicrobial Residue Accumulation Contributes to Higher Levels of Rhodococcus equi Carrying Resistance Genes in the Environment of Horse-Breeding Farms

Adaptation of Rhizosphere Microbial Communities to Continuous Exposure to Multiple Residual Antibiotics in Vegetable Farms

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