The fate of inhaled uranium-containing particles upon clearance to gastrointestinal tract

Respirable coal mine dust (RCMD) exposure is one of the utmost health hazards to the mining community causing various health issues, including coal worker pneumoconiosis (CWP). Considering multiple potential sources of RCMD having different physicochemical properties within the same mine suggests a wide range of health impacts that have not yet been studied extensively. In this work, we investigate the toxicity of lab-created RCMD based on different sources: coal seam, rock dust, host floor, and host roof collected from the same mine. Comparative samples obtained from several mines situated in various geographic locations were also assessed. This work quantifies metal leaching in simulated lung fluids and correlates dissolution with in vitro immune responses. Here, dissolution experiments were conducted using two simulated lung fluids; Gamble solution (GS) and artificial lysosomal fluid (ALF). In vitro studies were performed using a lung epithelial cell line (A549) to investigate their immune responses and cell viability. Si and Al are the most dissolved metals, among several other trace metals, such as Fe, Sr, Ba, Pb, etc. RCMD from the coal seam and the rock dust showed the least metal leaching, while the floor and roof samples dissolved the most. Results from in vitro studies showed a prominent effect on cell viability for floor and roof dust samples suggesting high toxicity.

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A Toxicological Study of the Respirable Coal Mine Dust: Assessment of Different Dust Sources within the Same Mine

Das

Salinas

LeBoeuf

et al. 2023

Minerals

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The fate of inhaled uranium-containing particles upon clearance to gastrointestinal tract

Abstract: Uranium-bearing respirable dust can cause various health problems, such as cardiovascular and neurological disorders, cancers, immunosuppression, and autoimmunity. Exposure to elevated levels of uranium is linked to many such health...

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A Toxicological Study of the Respirable Coal Mine Dust: Assessment of Different Dust Sources within the Same Mine

A Toxicological Study of the Respirable Coal Mine Dust: Assessment of Different Dust Sources within the Same Mine

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