The Fate of L5–S1 With Low-Dose BMP-2 and Pelvic Fixation, With or Without Interbody Fusion, in Adult Deformity Surgery

Annis, Prokopis; Brodke, Darrel S.; Spiker, W. Ryan; Daubs, Michael D.; Lawrence, Brandon D.

doi:10.1097/brs.0000000000000867

Cited by 35 publications

(25 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kim et al 15 justify that for long fusions to the sacrum BMP use significantly decreases pseudarthrosis rates in this patient population when compared with ICBG alone. Which corroborates with Annis et al 17 study where the use of low dose of BMP-2 at the L5–S1 level in combination with sacro-pelvic fixation achieved satisfactory fusion rates in adult deformity surgery.…”

Section: Discussionsupporting

confidence: 91%

“…Strategies for decreasing it include interbody fusion, use of BMP-2 at the lumbosacral junction, and the use of sacro-pelvic fixation, individually or in combination 17 . The repair in the lumbar spine presents a challenging surgical problem with high failure rates been reported, resulting from poor vascularity in a scarred fusion bed, inadequate posterior bony surface area, loss of sagittal alignment, and exposure to adverse systemic factors such as nicotine.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The use of bone morphogenetic proteins (BMP) and pseudarthrosis, a literature review

Oliveira

Martins

Lima

et al. 2017

Revista Brasileira de Ortopedia (English Edition)

View full text Add to dashboard Cite

Bone morphogenetic proteins (BMP) are multi-functional growth factors to promote bone healing with the proposal of less morbidity compared to the usual methods of bone graft harvest. Pseudoarthrosis occur when the fusion attempt fails, a solid fusion is not achieved, or there is motion across the segment leading to it, and it can be clinically symptomatic as pain, deformity, neurocompression, or hardware failure. BMPs are used at spinal fusion as a tool for the treatment of degenerative, traumatic, neoplastic and infectious conditions of the spine. This review shows that the use of BMPS is effective and secure when compared with iliac crest bone graft (ICGB); however, depending of the location of usage (cervical spine, lumbar spine or sacrum) and the medical status of the patient (presence of comorbidities, tobacco usage), it is more likely to exhibit complications. Therefore, the use of these proteins must be an informed decision of patient and physician preferences.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The use of bone morphogenetic proteins (BMP) and pseudarthrosis, a literature review

Oliveira

Martins

Lima

et al. 2017

Revista Brasileira de Ortopedia (English Edition)

View full text Add to dashboard Cite

show abstract

“… 30 , 33 , 34 Patients required deformity correction via Smith-Peterson osteotomies or pedicle subtraction osteotomies. Anterior lumbar interbody fusion (ALIF), posterior lumbar interbody fusion (PLIF), or transforaminal lumbar interbody fusion (TLIF) were supplementally performed in some patients, 19 , 37 , 38 depending on prior history of abdominal surgeries and irradiation, comorbidities, and surgeons’ preference. BMP-2 (INFUSE, Medtronic, Minneapolis, MN, USA) was used off-label for posterolateral fusion in some cases.…”

Section: Methodsmentioning

confidence: 99%

“… 10 , 11 In light of these risk factors, a wide variety of treatment strategies have been explored, such as vertebral cement augmentation, 12 - 15 dynamic spine stabilization, 16 and minimally invasive instrumentation placement. 17 To prevent pseudarthrosis, use of iliac screws (IS) for long-segment fusion ending at the sacrum or other pelvic fixation techniques such as the Galveston technique, 18 use of bone morphogenetic protein–2 (BMP-2), 19 and simultaneous or subsequent L5-S1 interbody fusion 20 have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Comparison Between S2-Alar-Iliac Screw Fixation and Iliac Screw Fixation in Adult Deformity Surgery: Reoperation Rates and Spinopelvic Parameters

Ishida

Elder

Holmes

et al. 2017

Global Spine Journal

View full text Add to dashboard Cite

Study Design:Retrospective cohort study.Objective:The S2-alar-iliac (S2AI) technique has been described as an alternative method for pelvic fixation in place of iliac screws (ISs) in spinal deformity surgery. The objective of this study was to analyze the impact of S2AI screws on radiographical outcomes, including spinopelvic parameters.Methods:A retrospective review of 17 patients receiving ISs and 46 patients receiving S2AI screws for correction of adult spinal deformity between 2010 and 2015 with minimum 1-year follow-up was conducted. Patient data on postoperative complications, including reoperation rates and proximal junctional kyphosis (PJK), and radiographical parameters was collected and statistically analyzed.Results:With mean follow-up of 21.1 months, the overall reoperation rate was significantly lower in the S2AI group than in the IS group (21.7% vs 58.8%, P = .01), but the incidence of PJK was similar (32.6% vs 35.3%, P > .99). Moreover, the time to reoperation in the IS group was significantly shorter than in the S2AI group (P = .001), and the S2AI group trended toward a longer time to reoperation due to PJK (P = .08). There was a significantly higher change in pelvic incidence (PI) in the S2AI group (−6.0°) compared with the IS group (P = .001).Conclusions:Compared with the IS technique, the S2AI technique demonstrated a lower rate of overall reoperation, a similar rate of PJK, longer time to reoperation, and possible reduction in PI. Future studies may be warranted to clarify the mechanism of these results and how they can be translated into improved patient care.

show abstract

“…One carrier with this ability is HA. HA is used as a bone graft extender for posterolateral spinal fusion in humans [ 12 ]. It is also useful as an ErhBMP-2 carrier because of its high affinity for ErhBMP-2.…”

Section: Introductionmentioning

confidence: 99%

Rapid bone regeneration by Escherichia coli -derived recombinant human bone morphogenetic protein-2 loaded on a hydroxyapatite carrier in the rabbit calvarial defect model

et al. 2015

View full text Add to dashboard Cite

BackgroundThe aim of this study was to determine the osteoconductivity of hydroxyapatite particles (HAP) as a carrier for Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2). Two 8-mm diameter bicortical calvarial defects were created in each of 20 rabbits. One of each pair of defects was randomly assigned to be filled with HAP only (HAP group) or ErhBMP-2 loaded HAP (ErhBMP-2/HAP group), while the other defect was left untreated (control group). The animals were killed after either 2 weeks (n = 10) or 8 weeks (n = 10) of healing, and histological, histomorphometric, and tomographic analyses were performed.ResultsAll experimental sites showed uneventful healing during the postoperative healing period. In both histomorphometric and tomographic analyses, the new bone area or volume of the ErhBMP-2/HAP group was significantly greater than that of the HAP and control groups at 2 weeks (p < 0.05). However, at 8 weeks, no significant difference in new bone area or volume was observed between the ErhBMP-2/HAP and HAP groups. The total augmented area or volume was not significantly different between the ErhBMP-2/HAP and HAP groups at 2 and 8 weeks.ConclusionsCombining ErhBMP-2 with HAP could significantly promote rapid initial new bone formation. Moreover, HAP graft could increase new bone formation and space maintenance, therefore it might be one of the effective carriers of ErhBMP-2.

show abstract

The Fate of L5–S1 With Low-Dose BMP-2 and Pelvic Fixation, With or Without Interbody Fusion, in Adult Deformity Surgery

Abstract: 4.

Cited by 35 publications

References 50 publications

The use of bone morphogenetic proteins (BMP) and pseudarthrosis, a literature review

The use of bone morphogenetic proteins (BMP) and pseudarthrosis, a literature review

Comparison Between S2-Alar-Iliac Screw Fixation and Iliac Screw Fixation in Adult Deformity Surgery: Reoperation Rates and Spinopelvic Parameters

Rapid bone regeneration by Escherichia coli -derived recombinant human bone morphogenetic protein-2 loaded on a hydroxyapatite carrier in the rabbit calvarial defect model

Contact Info

Product

Resources

About