The Fate of Leydig Cells in Men with Spermatogenic Failure

Adamczewska, Daria; Słowikowska-Hilczer, Jolanta; Walczak-Jędrzejowska, Renata

doi:10.3390/life12040570

Cited by 18 publications

(10 citation statements)

References 305 publications

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“…The results of observing and calculating the sperm motility of mice found a decrease in the percentage of sperm motility in mice after receiving treatment according to each group of mice. This result was following the statement of Adamczewska et al 19 and Whirledge et al 20 stated that increasing stress in mice can cause process barriers at the hypothalamic level and cause hormonal disturbances, failing Leydig cells to secrete the hormone testosterone. As a result, there is a disruption in the process of sperm maturation in the epididymis, especially disturbances in the glycolysis process.…”

Section: Discussionsupporting

confidence: 61%

Effect of Giving Traditional Drinks Kameko and Pongasih from Southeast Sulawesi on Sperm Quality of Mice (Mus musculus)

Hafizah¹,

Tien²,

Akka³

et al. 2022

Pakistan J. of Biological Sciences

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Background and Objective: The traditional beverage of Southeast Sulawesi is Kameko and Pongasih, which is a traditional alcoholic beverage. One of the bad effects of alcohol on reproductive health is the occurrence of infertility. This research aimed to determine the effect of consuming traditional beverages of Kameko and Pongasih on the quality of sperm of mice (Mus musculus). Materials and Methods: This research used a true experiment. The samples were some healthy mice (Mus musculus) aged 6-8 weeks as much 24 tails and divided into 4 groups. On the 36th day after the treatment was completed, the mice were terminated and prepared for microscopic sperm quality analysis. The quality of sperm includes motility, viability, concentration and morphology. The data test uses the Shapiro-Wilk Test, One-way ANOVA and post hoc LSD Test. Results: Kameko traditional beverage had a significant influence on sperm quality with motility, morphology, sperm concentration (p = 0.000) and viability (p = 0.001). Pongasih traditional beverage has a significant influence on sperm quality with motility parameter, morphology, sperm concentration (p = 0.000) and viability (p = 0.001). Kameko and Pongasih traditional beverages did not have a significant difference in sperm quality with motility parameter (p = 0.463), viability (p = 1.000), morphology (p = 0.553) and amount of concentration (p = 0.714). Conclusion: South East Sulawesi traditional beverages Kameko and Pongasih have effects on miceʼs (Mus musculus) sperm quality, but there was no difference in the group of mice which have been given Kameko and Pongasih.

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Section: Discussionsupporting

confidence: 61%

Effect of Giving Traditional Drinks Kameko and Pongasih from Southeast Sulawesi on Sperm Quality of Mice (Mus musculus)

Hafizah¹,

Tien²,

Akka³

et al. 2022

Pakistan J. of Biological Sciences

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“…An increase in LH levels but normal testosterone levels indicate normal pituitary compensation and leydig cell malfunction. 22 The mean estradiol levels in all men sampled were within normal limits. This maybe as a result of the fact that circulating androgens and testes are converted peripherally to produce estradiol.…”

Section: Reproductive Hormones and Semen Analysismentioning

confidence: 74%

“…A study in Germany found that a history of UDT was associated with high LH levels, lower testosterone levels, and lower estradiol levels. 22 Nevertheless, a study conducted showed that men with bilateral UDT had significantly higher levels of LH, but their estradiol levels were no different from normal men. 8 All of the men's average AMH levels fell within the normal range and did not differ significantly between all groups.…”

Section: Reproductive Hormones and Semen Analysismentioning

confidence: 97%

Impact of Men with Undescended Testis on Fertility and Hormonal Function Promoting Hypogonadism

Yuri,

Wenang,

Midwifery

et al. 2023

Bangladesh J Med Sci

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Objectives: Undescended testes or cryptorchidism is a disorder in men and is associated with hypogonadism and infertility. UDT is the majority factor in male adults. Studies on the effects of UDT on hormoneassociated hypogonadism are limited. Materials and Methods: This study aimed to assess the effects of UDT on fertility and testicular hormonal function in adult men. Data from medical records were gathered, laboratory tests, and retrospective interviews from 2018 to 2020. The independent variable was men with UDT, while the dependent variable was fertility and reproductive hormones that trigger hypogonadism. Data on infertility, reproductive hormones, semen analysis, and symptoms of hypogonadism from 20 patients with and without UDT. ANOVA, Kruskal-Wallis test, Pearson chi-square test, and Fisher’s exact test helped perform the analysis. Results and Discussion: Undescended testes were associated with infertility so that levels of FSH and LH were considerably greater than men without UDT (p < 0.05). Bilateral UDT men had the highest levels of FSH and LH but not significantly different from unilateral UDT (p > 0.05). Bilateral UDT men had the lowest mean estradiol, testosterone and sperm quality (p < 0.05). All men had prolactin and AMH levels within normal limits (p > 0.05). Men with UDT had more significant hypogonadal symptoms (p < 0.001) Conclusion: Infertility, FSH, and LH levels were highest in men with bilateral UDT, but testosterone and estradiol levels were lowest. It also has the worst sperm quality and the most hypogonadal symptoms. All of the men had normal prolactin and AMH levels. Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 859-868

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“…Leydig cell hyperplasia (LCH) is common among men with NOA. LCH can occur with an increased number of Leydig cells that display intertubular growth patterns and form multiple clusters ( 26 ). This differs from the LCT that usually presents as a well-defined, solitary nodule ( 26 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

X-linked RBBP7 mutation causes maturation arrest and testicular tumors

Li,

Zheng,

Hou

et al. 2023

Journal of Clinical Investigation

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Maturation arrest (MA) is a subtype of non-obstructive azoospermia, and male infertility is a known risk factor for testicular tumors. However, the genetic basis for many affected individuals remains unknown. Here, we identified a deleterious hemizygous variant of X-linked retinoblastoma-binding protein 7 ( RBBP7 ) as a potential key cause of MA, which was also found to be associated with the development of Leydig cell tumors. This mutation resulted in premature protein translation termination, affecting the sixth WD40 domain of the RBBP7 and the interaction of the mutated RBBP7 with histone H4. Decreased BRCA1 and increased γH2AX were observed in the proband. In mouse spermatogonial and pachytene spermatocyte-derived cells, deprivation of rbbp7 led to cell cycle arrest and apoptosis. In Drosophila , knockdown of RBBP7/Caf1-55 in germ cells resulted in complete absence of germ cells and reduced testis size, whereas knockdown of RBBP7/Caf1-55 in cyst cells resulted in hyperproliferative testicular cells. Interestingly, male infertility caused by Caf1-55 deficiency was rescued by ectopic expression of wild-type human RBBP7 but not mutant variants, suggesting the importance of RBBP7 in spermatogenesis. Our study provides insights into the mechanisms underlying the co-occurrence of MA and testicular tumors and may pave the way for innovative genetic diagnostics of these 2 diseases.

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The Fate of Leydig Cells in Men with Spermatogenic Failure

Cited by 18 publications

References 305 publications

Effect of Giving Traditional Drinks Kameko and Pongasih from Southeast Sulawesi on Sperm Quality of Mice (Mus musculus)

Effect of Giving Traditional Drinks Kameko and Pongasih from Southeast Sulawesi on Sperm Quality of Mice (Mus musculus)

Impact of Men with Undescended Testis on Fertility and Hormonal Function Promoting Hypogonadism

X-linked RBBP7 mutation causes maturation arrest and testicular tumors

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