The fate of mamaku gum in the gut: effect on <i>in vitro</i> gastrointestinal function and colon fermentation by human faecal microbiota

Bisht, Akshay; Goh, Kelvin K.T.; Matía-Merino, Lara

doi:10.1039/d3fo01665j

Food Funct.

2023

DOI: 10.1039/d3fo01665j

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The fate of mamaku gum in the gut: effect on in vitro gastrointestinal function and colon fermentation by human faecal microbiota

Akshay Bisht

Kelvin K.T. Goh

Lara Matía-Merino

Abstract: Mamaku gum, extracted from the New Zealand Black Tree Fern can affect in vitro gastrointestinal enzyme activity and colonic fermentation.

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Cited by 8 publications

References 83 publications

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Insights Into Metabolic Signatures and Regulatory Effect of Dendrobium officinale Polysaccharides in Gut Microbiota: A Comparative Study of Healthy and Diabetic Status

Song,

Zou,

Cheng

et al. 2024

Food Science & Nutrition

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Dendrobium officinale is a kind of popular functional food to be consumed by both healthy and diabetic people. As its major constituent, D. officinale polysaccharide (DOP) is mainly utilized by gut microbiota. Despite distinctive gut microbiota composition between healthy and diabetic individuals, no study compared the interplay between DOP and gut microbiota under healthy and diabetic status. The current study aims to investigate and compare the metabolic signatures and regulatory potential of DOP on gut microbiota between healthy and diabetic status. Our serial in vitro fermentation investigations found that mannose in DOP was more utilized by gut microbiota under diabetic status with higher production of propanoic acid and lower production of butyric acid compared with those under healthy status. Moreover, metabolomic analyses revealed different impacts of DOP on intestinal microbial metabolites between healthy and diabetic status with upregulating taurine and downregulating 2‐hydroxybutyric acid only occurring under diabetic status. Biodiversity analyses demonstrated that DOP treatment could only significantly improve the diversity of gut microbiota under diabetic status while there was no significant effect on that under healthy status. Further gut microbiota composition analyses indicated that DOP treatment could promote probiotics (Dubosiella, Bifidobacterium, and Akkermansia) under both healthy and diabetic status while inhibit pathogens (Escherichia‐Shigella) only under diabetic status. In summary, our current insights into metabolic signatures and regulatory effects of DOP in the gut microbiota under healthy and diabetic status provided scientific evidence for its broad use as functional food.

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Insights Into Metabolic Signatures and Regulatory Effect of Dendrobium officinale Polysaccharides in Gut Microbiota: A Comparative Study of Healthy and Diabetic Status

Song,

Zou,

Cheng

et al. 2024

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

Interplay between traditional Chinese medicine polysaccharides and gut microbiota: The elusive “polysaccharides‐bond‐bacteria‐enzyme” equation

Rong,

Shen,

Shu

2024

Phytotherapy Research

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Polysaccharides are one of the most important components of traditional Chinese medicine (TCM) and have been extensively studied for their immunomodulatory properties. The functions and effects of TCM polysaccharides are closely related to the gut microbiota, making the study of their interaction a hot topic in the field of TCM metabolism. This review follows two main inquiries: first, how the gut microbiota breaks down TCM polysaccharides to produce bioactive metabolites; and second, how TCM polysaccharides reshape the gut microbiota as a carbon source. Understanding the interaction mechanism involves a challenging equation of the structural association of TCM polysaccharides with the metabolic activities of the microbiota. This review has meticulously searched, partially organized literature spanning the past decade, that delves into the interaction mechanism between TCM polysaccharides and gut microbiota. It also gives an overview of the complex factors of the elusive “polysaccharides‐bond‐bacteria‐enzyme” equation: the complexity of polysaccharide structures, the diversity of glycosidic bond types, the communal nature of metabolizing microbiota, the enzymes involved in functional degradation by microbiota, and the hierarchical roles of polysaccharide utilization locus and gram‐positive PULs. Finally, this review aims to facilitate discussion among peers in the field of TCM microbiota and offers prospects for research in related fields, paving the way for pharmacological studies on TCM polysaccharides and gut microbiota therapeutics, and providing a reference point for further clinical research.

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Acid resistance of different polysaccharide hydrocolloids: pH effects

Cui,

Ai,

Xiong

et al. 2024

Bioactive Carbohydrates and Dietary Fibre

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The fate of mamaku gum in the gut: effect on in vitro gastrointestinal function and colon fermentation by human faecal microbiota

Abstract: Mamaku gum, extracted from the New Zealand Black Tree Fern can affect in vitro gastrointestinal enzyme activity and colonic fermentation.

Cited by 8 publications

References 83 publications

Insights Into Metabolic Signatures and Regulatory Effect of Dendrobium officinale Polysaccharides in Gut Microbiota: A Comparative Study of Healthy and Diabetic Status

Insights Into Metabolic Signatures and Regulatory Effect of Dendrobium officinale Polysaccharides in Gut Microbiota: A Comparative Study of Healthy and Diabetic Status

Interplay between traditional Chinese medicine polysaccharides and gut microbiota: The elusive “polysaccharides‐bond‐bacteria‐enzyme” equation

Acid resistance of different polysaccharide hydrocolloids: pH effects

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