1976
DOI: 10.1016/0002-9610(76)90351-2
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The fate of patients with intermittent claudication managed nonoperatively

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Cited by 96 publications
(25 citation statements)
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“…Claudication and CLI represent a continuum of the same atherosclerotic process. The expected rate of progression from claudication to amputation is reported as 1% per year, although more than 20% of claudicants will develop incapacitating LLC, seriously restricting the quality of life and independence of older patients (1,2,18,19). Surgical options for patients with severe LLC are limited, especially if venous conduit must be conserved for future coronary artery bypass.…”
Section: Discussionmentioning
confidence: 99%
“…Claudication and CLI represent a continuum of the same atherosclerotic process. The expected rate of progression from claudication to amputation is reported as 1% per year, although more than 20% of claudicants will develop incapacitating LLC, seriously restricting the quality of life and independence of older patients (1,2,18,19). Surgical options for patients with severe LLC are limited, especially if venous conduit must be conserved for future coronary artery bypass.…”
Section: Discussionmentioning
confidence: 99%
“…17,39 Soon after its onset, PAD stabilizes clinically in 65-75% of patients, with only 25-35% deteriorating significantly. 17,40 -42 The amputation rate in hospital patients with PAD is 7% in 6 years; 41,43 however, in large population studies 17,44,45 among patients with claudication the rate is lower (2%). Although the impact of atherosclerosis on the life span of claudicants is high (5-30% 5-year cumulative mortality rate in males), 17,46 only 3-22% of those who seek medical advice for their PAD will ever require revascularization.…”
Section: Delis and Nicolaidesmentioning
confidence: 99%
“…PAD is associated with symptomatic claudication in approximately 20-40% of persons with PAD and thereby causes a deterioration of quality of life. [1][2][3][4][5][6] PAD is also a potent predictor of cardiovascular ischemic events (e.g. angina, myocardial infarction, and stroke) and death.…”
Section: Introductionmentioning
confidence: 99%