The fate of radiocarbon-labeled propoxyphene in rat, dog, and human

McMahon, Robert E.; Ridolfo, Anthony S.; Culp, Hilman W.; Wolen, Robert L.; Marshall, Frederick J.

doi:10.1016/0041-008x(71)90002-0

Cited by 72 publications

(11 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…McMahon et al (15) have shown that the major metabolite of propoxyphene in the human is norpropoxyphene which is in turn converted to norpropoxyphene amide during the extraction process. Kaiko et al (11) have observed the conversion of NNAM to AMIDE at pH > 10.…”

Section: Resultsmentioning

confidence: 99%

Isotope Dilution Technique for the Estimation of l-Alpha-[2-3H]-Acetylmethadol and Its Metabolites in Biological Samples

Man¹,

Harris²,

Woods³

et al. 1980

Pharmacology

View full text Add to dashboard Cite

An isotope dilution technique for the determination of l-α-(2-³H)-acetylmethadol and its metabolites from biological samples is described. The parent drug and metabolites were extracted from biological samples with chlorobutane after the addition of unlabeled internal standards. The extracts were purified by two-dimensional thin-layer chromatography for quantification by gas-liquid chromatography and scintillation counting. Dinoracetylmethadol (NNAM) was found to be converted to 6-acetamido-4,4-diphenyl-3-heρtanol (AMIDE) during the extraction procedure. The conversion of NNAM to AMIDE was confirmed by gas chromatography-mass spectrometry.

show abstract

Section: Resultsmentioning

confidence: 99%

Isotope Dilution Technique for the Estimation of l-Alpha-[2-3H]-Acetylmethadol and Its Metabolites in Biological Samples

Man¹,

Harris²,

Woods³

et al. 1980

Pharmacology

View full text Add to dashboard Cite

show abstract

“…Studies in humans with unlabelled materials showed that the main metabolite excreted in the urine was N-demethylated propoxyphene (norpropoxyphene). Further work (McMahon et al, 1971) with [1-14C] propoxyphene showed that urinary excretion is the main route of elimination of propoxyphene 38S metabolites in man. Ring hydroxylation and glucuronide formation are less important metabolic pathways.…”

Section: Biotransformationmentioning

confidence: 96%

Pharmacokinetics of Propoxyphene

Pearson

1984

Human Toxicology

View full text Add to dashboard Cite

“…One further problem in the assay of nordextropropoxyphene by the procedure described here arises from the instability of this compound in neutral or basic solution (McMahon et al, 1971). Although the standard solutions are stable for at least 6 months if stored in 1 ml portions at -20 °C, at room temperature decomposition may be marked even during the course of a working day.…”

Section: Qualitative Analysismentioning

confidence: 98%

“…Such procedures are advantageous in that many other drugs may be detected and identified simultaneously. Nordextropropoxyphene, the principal metabolite of dextropropoxyphene found in human urine, is unstable and, especially under strongly basic conditions, undergoes an intramolecular acyl shift to yield a stable amide, nordextropropoxyphene amide (McMahon et al, 1971). …”

Section: Qualitative Analysismentioning

confidence: 98%

Measurement of Dextropropoxyphene and Nordextropropoxyphene in Biological Fluids

1984

View full text Add to dashboard Cite

1 Detection, identification and measurement of dextropropoxyphene and its principal plasma metabolite, nordextropropoxyphene, can be important in the diagnosis of acute poisoning. 2 A combination of thin-layer chromatography (TLC) and gas-liquid chromatography (GLC) of solvent or solid-phase extracts of urine or gastric contents usually serves to detect these and many other compounds, and an homogeneous enzyme immunoassay (EMIT-DAU) is also available for dextropropoxyphene. 3 Measurement of dextropropoxyphene by GLC is complicated by the instability of this compound under certain conditions. However, a relatively polar stationary phase such as Carbowax 20M together with nitrogen-selective detection can give adequate sensitivity and selectivity for the measurement of the plasma concentrations attained after overdosage. 4 High-performance liquid chromatography (HPLC) has not been widely applied in the assay of dextropropoxyphene and nordextropropoxyphene since these compounds have no pronounced ultraviolet absorption or fluorescence spectra. However, electrochemical oxidation detection can be used with a silica column/non-aqueous ionic eluent system. This gives good selectivity and sensitivity, and can facilitate the measurement of both compounds in plasma specimens after single oral dosage.

show abstract

The fate of radiocarbon-labeled propoxyphene in rat, dog, and human

Cited by 72 publications

References 16 publications

Isotope Dilution Technique for the Estimation of <i>l</i>-Alpha-[2-<sup>3</sup>H]-Acetylmethadol and Its Metabolites in Biological Samples

Isotope Dilution Technique for the Estimation of <i>l</i>-Alpha-[2-<sup>3</sup>H]-Acetylmethadol and Its Metabolites in Biological Samples

Pharmacokinetics of Propoxyphene

Measurement of Dextropropoxyphene and Nordextropropoxyphene in Biological Fluids

Contact Info

Product

Resources

About