The fatty acid profile of adipose tissue as a predictor of the ponderal and inflammatory response in adult women six years after bariatric surgery

Almeida, Cecília Calhau; Viana, Elaine Cristina; Moreira, Ana Vládia Bandeira; Miguel, Gustavo Peixoto Soares; Pedra, Fernanda Semião Garcia; Oliveira, Fabiana Eleotério; Quimquim, Tayla Neves; Bissoli, Nazaré Souza; Alves, Raquel Duarte Moreira; Bressan, Josefina

doi:10.1186/s12944-020-01229-3

Cited by 7 publications

(7 citation statements)

References 45 publications

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“…In the mulberry silage group, amounts of oleic acid (C 18:1 ), MUFA, stearic acid (C 18:0 ), SFA, myristic acid (C 14:0 ), and arachidonic acid (C 20:1 ) decreased, whereas amounts of ω-3FA, α-linolenic acid (C 18:3 ), arachidonic acid (C 20:2 and C 20:4 ), linoleic acid (C 18:2 ), PUFA, and ω-6FA increased. The α-linolenic acid (C 18:3 ) is the precursor of long-chain ω-3 fatty acids, which have a wide range of anti-inflammatory and cardioprotective effects ( 29 ). The ω-3FAs are most beneficial to human health and can reduce cholesterol and triglyceride contents in plasma and help prevent cardiovascular diseases ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Silage Diet on Meat Quality through Shaping Gut Microbiota in Finishing Pigs

Niu

Liu

et al. 2023

Microbiol Spectr

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Section: Discussionmentioning

confidence: 99%

Effects of Silage Diet on Meat Quality through Shaping Gut Microbiota in Finishing Pigs

Niu

Liu

et al. 2023

Microbiol Spectr

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“…Elevated body mass index, dyslipidemia, and hypertension, besides the hormonal modifications observed in postmenopause, are associated with increasing white adipose tissue. These metabolic alterations are related to increased release of inflammatory markers leading to a low-grade inflammatory state promoted by augmented serum levels of IL-6 and TNF-α and reduction in IL-10 [26][27][28][29][30]34]. A chronic low-grade inflammatory state is evident in postmenopause women, and controlling this condition can be relevant for the prevention of the most common diseases in women [35].…”

Section: Discussionmentioning

confidence: 99%

“…The ovarian dysfunction in postmenopause may contribute to the increase of proinflammatory cytokines. Some, such as TNF-α, seem to aggravate hypertension associated with hyperglycemia, visceral obesity, and dyslipidemia to configure the MS scenario [24][25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women

et al. 2022

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The increased deposition of visceral fat in the postmenopause period increases the production of inflammatory cytokines and the release of tumor necrosis factor- α (TNF-α), interleukin-6 (IL-6), and decrease in IL-10. This study investigated the relationship between inflammatory biomarkers and metabolic syndrome (MS) in postmenopausal women considering different diagnostic criteria. We conducted a cross-sectional observational study based on STROBE. Data were collected regarding the diagnostic criteria for MS (International Diabetes Federation; NCEP (International Diabetes Federation (IDF), National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III), and Harmonized criteria), body composition, comorbidities, time without menstruation, values of IL-6, IL-10, and TNF-α. ANOVA, Kruskal–Wallis, Levene tests, ROC, and odds ratio were performed to analyze the data. The results showed no significant difference between the methods and no interaction between the method and the presence of MS. However, for the values of WC, body fat percentage, TNF-α, and IL-10/TNF-α ratio, a significant effect of MS was observed. In subjects with MS, lower values of body fat percentage and TNF-α and higher values of the IL-10/TNF-α ratio were also observed. The higher IL-10/TNF-α ratio in the MS group is related to the greater anti-inflationary action of IL-10. The IL-10/TNF-α ratio showed significant accuracy to discriminate patients with MS according to the NCEP-ATP III criteria.

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“…The inclusion criteria encompassed individuals aged 18 years or older, with a BMI between 35 and 45 kg/m 2 , who underwent surgery using the Roux-en-Y bypass method [ 25 , 42 , 46 ], in accordance with the indication criteria outlined in the legislation of the Ministry of Health of Brazil [ 47 ], and expressed willingness to participate by signing the Informed Consent Form (ICF).…”

Section: Methodsmentioning

confidence: 99%

“…The Roux-en-Y gastric bypass procedure was standardized with a 40 cm biliopancreatic limb length and 150 cm alimentary limb length [ 25 , 42 , 46 ].…”

Section: Methodsmentioning

confidence: 99%

Dynamic Changes in Adiponectin and Resistin Drive Remission of Cardiometabolic Risk Biomarkers in Individuals with Obesity Following Bariatric Surgery

Fiorotti,

Gomes,

Bortoli

et al. 2024

Pharmaceuticals

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The remission of obesity-related diseases following bariatric surgery appears to result from the reorganization of metabolic and hormonal pathways involving adipokines. This study aimed to investigate the relationship between changes in body adiposity and serum adipokine levels, as well as the association between variations in adiponectin or resistin levels and cardiometabolic risk blood biomarkers before and after Roux-en-Y gastric bypass. A longitudinal and prospective study was conducted with bariatric surgery patients. Anthropometric, body composition and blood biochemical parameters were measured before and at 2 and 6 months post-surgery. The data were analyzed using ANOVA, Pearson or Spearman correlation, and simple linear regression with a significance level of p < 0.05. Among 36 mostly female patients aged 30 to 39 years, significant reductions in body weight (−26.8%), fat mass (−50%), waist circumference (−18%) and waist-to-height ratio (−22%) were observed post-surgery. Serum adiponectin levels increased (+107%), while resistin (−12.2%), TNF-α (−35%), and PAI-1 (−11.1%) decreased. Glucose, insulin, CRP, cholesterol, LDL-c, triglycerides, and vitamin D also decreased. Waist circumference variation showed a positive correlation with PAI-1 and TNF-α and a negative correlation with adiponectin. The total fat mass showed a positive correlation with PAI-1. Adiponectin variation correlated negatively with glucose, resistin, and CRP but positively with HDL-c. Resistin showed a positive correlation with insulin and CRP. In conclusion, 6 months post-bariatric surgery, reducing abdominal adiposity had a more significant impact on serum adipokine levels than total fat mass. Adiponectin increase and resistin decrease acted as endocrine mediators driving the remission of cardiometabolic risk biomarkers in individuals with obesity following Roux-en-Y gastric bypass.

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The fatty acid profile of adipose tissue as a predictor of the ponderal and inflammatory response in adult women six years after bariatric surgery

Cited by 7 publications

References 45 publications

Effects of Silage Diet on Meat Quality through Shaping Gut Microbiota in Finishing Pigs

Effects of Silage Diet on Meat Quality through Shaping Gut Microbiota in Finishing Pigs

Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women

Dynamic Changes in Adiponectin and Resistin Drive Remission of Cardiometabolic Risk Biomarkers in Individuals with Obesity Following Bariatric Surgery

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