The Favorable Effect of Style of Zea mays L. on Streptozotocin Induced Diabetic Nephropathy

Suzuki, Ryuichiro; Okada, Yoshihito; Okuyama, Toru

doi:10.1248/bpb.28.919

Cited by 31 publications

(12 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Elevated blood glucose can damage the cells and microblood vessels of the kidney [28]. Our previous study found that FPS affected chronic renal failure and diabetic complications [15,22].…”

Section: Resultsmentioning

confidence: 99%

The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy

Wang

Liu

et al. 2014

Marine Drugs

View full text Add to dashboard Cite

Diabetic nephropathy (DN) has long been recognized as the leading cause of end-stage renal disease, but the efficacy of available strategies for the prevention of DN remains poor. The aim of this study was to investigate the possible beneficial effects of fucoidan (FPS) in streptozotocin (STZ)-induced diabetes in rats. Wistar rats were made diabetic by injection of STZ after removal of the right kidney. FPS was administered to these diabetic rats for 10 weeks. Body weight, physical activity, renal function, and renal morphometry were measured after 10 weeks of treatment. In the FPS-treated group, the levels of blood glucose, BUN, Ccr and Ucr decreased significantly, and microalbumin, serum insulin and the β2-MG content increased significantly. Moreover, the FPS-treated group showed improvements in renal morphometry. In summary, FPS can ameliorate the metabolic abnormalities of diabetic rats and delay the progression of diabetic renal complications.

show abstract

“…Elevated blood glucose can damage the cells and microblood vessels of the kidney [28]. Our previous study found that FPS affected chronic renal failure and diabetic complications [15,22].…”

Section: Resultsmentioning

confidence: 99%

The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy

Wang

Liu

et al. 2014

Marine Drugs

View full text Add to dashboard Cite

show abstract

“…In Mexico this preparation is also used to manage diabetes (Andrade-Cetto et al, 2006;Andrade-Cetto and Heinrich, 2005). Accordingly, Suzuki et al (2005) showed a positive effect of the style of this species on streptozotocin-induced diabetic nephropathy (Suzuki et al, 2005). The flavones, chrysoeriol 6-C-β-boivinopyranosyl-7-O-β glucopyranoside and chrysoeriol 6-Cβ-L-boivinopyranoside, have been isolated from the style of this species, and they exhibited glycation inhibitory activity (Suzuki et al, 2003), which provides some scientific explanation for the traditional use for diabetes in Mexico.…”

Section: Plant Species Used To Treat Diabetes and Its Sequelae In Cenmentioning

confidence: 99%

Medicinal plants used in the traditional management of diabetes and its sequelae in Central America: A review

Giovannini

Howes

Edwards

2016

Journal of Ethnopharmacology

122

View full text Add to dashboard Cite

This review provides an overview of the medicinal plants used to manage diabetes and its sequelae in Central America and of the current scientific knowledge that might explain their traditional use. In Central America a large number of medicinal plants are used to treat this condition and its sequelae, although relatively few species are widely used across the region. For the species used to manage diabetes, there is variation in the availability and quality of pharmacological, chemical and clinical studies to explain traditional use.

show abstract

“…Corn silk (CS), which is the yellowish thread-like strands from corn herbal hwabongwa (Zey mays L.), has been used as treatments for obesity, kidney-related diseases, neurodegenerative diseases, and diabetes [ 3 4 5 6 7 8 9 10 11 12 13 ]. CS extract includes various bio-functional substances such as tartaric acid, isoquercitrin, allantoin, stigmasterol, hordenine, maysin, resin, cryptoxanthin, and anticyanins [ 14 15 ].…”

Section: Introductionmentioning

confidence: 99%

Corn silk extract improves cholesterol metabolism in C57BL/6J mouse fed high-fat diets

Hoon

Kim²,

Kang³

et al. 2016

Nutr Res Pract

View full text Add to dashboard Cite

BACKGROUND/OBJECTIVESCorn silk (CS) extract contains large amounts of maysin, which is a major flavonoid in CS. However, studies regarding the effect of CS extract on cholesterol metabolism is limited. Therefore, the purpose of this study was to determine the effect of CS extract on cholesterol metabolism in C57BL/6J mouse fed high-fat diets.MATERIALS/METHODSNormal-fat group fed 7% fat diet, high-fat (HF) group fed 25% fat diet, and high-fat with corn silk (HFCS) group were orally administered CS extract (100 mg/kg body weight) daily. Serum and hepatic levels of total lipids, triglycerides, and total cholesterol as well as serum free fatty acid, glucose, and insulin levels were determined. The mRNA expression levels of acyl-CoA: cholesterol acyltransferase (ACAT), cholesterol 7-alpha hydroxylase (CYP7A1), farnesoid X receptor (FXR), lecithin cholesterol acyltransferase (LCAT), low-density lipoprotein receptor, 3-hyroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), adiponectin, leptin, and tumor necrosis factor α were determined.RESULTSOral administration of CS extract with HF improved serum glucose and insulin levels as well as attenuated HF-induced fatty liver. CS extracts significantly elevated mRNA expression levels of adipocytokines and reduced mRNA expression levels of HMG-CoA reductase, ACAT, and FXR. The mRNA expression levels of CYP7A1 and LCAT between the HF group and HFCS group were not statistically different.CONCLUSIONSCS extract supplementation with a high-fat diet improves levels of adipocytokine secretion and glucose homeostasis. CS extract is also effective in decreasing the regulatory pool of hepatic cholesterol, in line with decreased blood and hepatic levels of cholesterol though modulation of mRNA expression levels of HMG-CoA reductase, ACAT, and FXR.

show abstract

The Favorable Effect of Style of Zea mays L. on Streptozotocin Induced Diabetic Nephropathy

Cited by 31 publications

References 6 publications

The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy

The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy

Medicinal plants used in the traditional management of diabetes and its sequelae in Central America: A review

Corn silk extract improves cholesterol metabolism in C57BL/6J mouse fed high-fat diets

Contact Info

Product

Resources

About