The Fcγ Receptor IIA-R/R131 Genotype Is Associated with Severe Sepsis in Community-Acquired Pneumonia

Endeman, Henrik; Cornips, Marie Claire A.; Grutters, Jan C.; Bosch, J.L.H. Ruud; Ruven, Henk J.T.; Velzen‐Blad, Heleen van; Rijkers, Ger T.; Biesma, Douwe H.

doi:10.1128/cvi.00037-09

Cited by 42 publications

(31 citation statements)

References 19 publications

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“…The Fc␥RIIa-H131 allotype has higher binding efficiency for IgG2 and greater phagocytic capability for IgG2-opsonized bacteria than the Fc␥RIIa-R131 allotype. A recent study by Endeman et al showed that the Fc␥RIIa-R131R genotype was found more frequently in patients with severe community-acquired pneumonia caused by S. pneumoniae and H. influenzae (5). In our patients with bacterial coinfections, this association was not obvious (Table 3).…”

Section: Discussionmentioning

confidence: 49%

The Lower Serum Immunoglobulin G2 Level in Severe Cases than in Mild Cases of Pandemic H1N1 2009 Influenza Is Associated with Cytokine Dysregulation

Chan

Tse

et al. 2011

Clin Vaccine Immunol

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The majority of patients with pandemic influenza H1N1 2009 had mild illness, but some, including those with no risk factors for severe disease, may succumb to this infection. Besides viral factors such as the D222/225G substitution of the hemagglutinin, host factors such as IgG2 subclass deficiency recently was reported to be associated with severe disease in a cohort of Australian patients besides other known risk factors, including underlying chronic illness, extremes of age, and pregnancy. We conducted a case-control study of 38 Asian patients with respiratory failure due to severe pandemic influenza and compared the results to those for 36 mild cases. None had selective IgG2 deficiency, but the level of IgG2 subclass was significantly lower in the severe cases (3.55 g/liter versus 4.75 g/liter; P ‫؍‬ 0.002), whereas the levels of IgG1, IgG3, and IgG4 were not significantly different from those of the mild cases. Previous studies suggested that some IgHG2 and Fc␥RIIa genotypes were associated with IgG2 deficiency. The allelic frequency of the IgHG2 genotypes in our severe cases was not correlated with their levels of IgG2, while that of Fc␥RIIa was not significantly different from that of the general Han Chinese population (P ‫؍‬ 0.216). Only the overall cytokine/chemokine profile (P ‫؍‬ 0.029) and serum globulin level (P ‫؍‬ 0.005) were found to be independently associated with the IgG2 level by multivariate analysis. The lower IgG2 level in our severe group might be related to cytokine dysregulation rather than being a significant risk factor for severe pandemic influenza. The importance of this finding for therapeutic intervention will require further studies of larger cohorts of patients.

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Section: Discussionmentioning

confidence: 49%

The Lower Serum Immunoglobulin G2 Level in Severe Cases than in Mild Cases of Pandemic H1N1 2009 Influenza Is Associated with Cytokine Dysregulation

Chan

Tse

et al. 2011

Clin Vaccine Immunol

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“…For example, the low affinity variant of FcγRIIa (R131) confers increased susceptibility to severe bacterial infections and sepsis, likely due to impaired microbial clearance (37, 103, 104). In contrast, in dengue infection, where antibody-mediated enhancement (ADE) of virus infectivity can occur, this low binding FcγRIIa polymorphism is associated with asymptomatic infection and improved clinical outcomes (105, 106).…”

Section: Signaling and Function Of Anti-tumor Antibodiesmentioning

confidence: 99%

Signaling by Antibodies: Recent Progress

Bournazos

Wang²,

Dahan³

et al. 2017

Annu. Rev. Immunol.

182

184

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IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through Type I and Type II Fc receptors is required for the control of pro-inflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation, as well as determine susceptibility to infection and autoimmunity, and responsiveness to antibody-based therapeutics, and vaccine responses.

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“…[4] Our results also suggest that immune cells in patients' HI express different levels of ICAM-1 and therefore ICAM-1 during the formation of HI may be involved in the adhesion, capture, immune adjustment, and phagocytosis between immune cells and pathology hematopoietic cells.…”

Section: Discussionmentioning

confidence: 77%

“…So it plays an important biological role in killing intracellular pathogen. [4,12] Immunofluorescence staining showed that immune cells in three types of HI all secreted IL-12 which was closely related with elevated serum IL-12 levels. Meanwhile, in patients with AIRH CD19 + B lymphocytes and CD3 + CD8 + lymphocytes were significantly increased.…”

Section: Discussionmentioning

confidence: 98%

“…In addition, it plays a negative feedback effect on B lymphocyte activation. [4][5][6][7] MR, through its extracellular region, recognizes a variety of sugar molecules on the cell surface or the pathogen's cell wall and combines with them. Afterwards, these immune cells capture antigen, devour diseased blood cells by participating in receptor-mediated endocytosis and phagocytosis, and play an important biological effects in the maintenance of homeostasis and the body's innate immunity and adaptive immune defense process.…”

Section: Discussionmentioning

confidence: 99%

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Mechanisms of Immune Injury and Heterogeneity of Bone Marrow Hematopoietic Cells Island in Patients with Auto-Immuno-Related Hematocytopenia

Sun

Han

et al. 2014

Journal of Immunoassay and Immunochemistry

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Because of environmental pollution more and more people are suffered with auto-immuno-related hematocytopenia (AIRH). Serum IL-12, IL-17, and IFN-γ levels were detected by ELISA and lymphocyte subsets were analyzed by flow cytometry. Peroxidase (POX) and HLA-DR of immune cells were detected by cytochemical and immunochemical staining. Cells expressing anti-human IgG, FcγR II, MR, and other molecules in HI were detected by immunofluorescence. Serum IL-12, IL-17, and IFN-γ levels of patients were significantly higher than control group. Lymphocyte subsets of patients showed that the percentages of CD19+ B cells and CD3+ CD8+ T cell in peripheral blood were both significantly elevated. HI were mainly classified into three types, in these three types of hematopoietic cells island, peroxidase, and HLA-DR expression varied. Hematopoietic cells with pathological changes expressed anti-human IgG. The immunocytes with different levels of immunomolecules adhered captured and devoured abnormal hematopoietic cells. Immune cells expressed IL-12, IL-17A, and IL-17RA, leading to inflammatory injury of hematopoietic cells. HI destroys cells which connect auto-antibodies. Immune cells in HI express a variety of immune molecules, promote cell immune responses, and amplify the inflammatory reaction by ADCC effect or phagocytosis. These ultimately destruct directly and damage indirectly hematopoietic cells.

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The Fcγ Receptor IIA-R/R131 Genotype Is Associated with Severe Sepsis in Community-Acquired Pneumonia

Cited by 42 publications

References 19 publications

The Lower Serum Immunoglobulin G2 Level in Severe Cases than in Mild Cases of Pandemic H1N1 2009 Influenza Is Associated with Cytokine Dysregulation

The Lower Serum Immunoglobulin G2 Level in Severe Cases than in Mild Cases of Pandemic H1N1 2009 Influenza Is Associated with Cytokine Dysregulation

Signaling by Antibodies: Recent Progress

Mechanisms of Immune Injury and Heterogeneity of Bone Marrow Hematopoietic Cells Island in Patients with Auto-Immuno-Related Hematocytopenia

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