The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) - an update on the status

“…In vitro study was done in February 2020, by Chinese researchers has showen darunavir significantly inhibited SARS-CoV-2 replication and its inhibition efficacy was more than that in the untreated group by 280-fold [68]. An anti-parasitic drug called ivermectin has been shown to be effective against the SARS-CoV-2 virus in an in-vitro study by researchers at Monash University in Melbourne, Australia [69]. Further clinical trials need to be completed to confirm the effectiveness of the drug in humans with COVID-19.…”

Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses

“…Recently Caly et al reported in vitro activity of ivermectin against SARS-CoV-2 following a single addition to Vero-hSLAM cells, and suggest that these data "demonstrate that ivermectin is worthy of further consideration as a possible SARS-CoV-2 antiviral" [1]. In isolation, these in vitro data are robust and encouraging but the report does not include a correlation of the in vitro findings with clinically achievable plasma and, more relevantly, lung concentrations that would permit the determination of whether the macrocyclic lactones (and specifically in this case ivermectin) are genuine therapeutic options.…”

“…The 5 th and 95 th percentiles are also shown. The red-line is the IC 50 (2µM) against SARS-CoV-2 determined in vitro by Caly et al[1]…”

Potential use of hydroxychloroquine, ivermectin and azithromycin drugs in fighting COVID-19: trends, scope and relevance

“…Another study revealed that ivermectin which is a broad spectrum anti-parasitic drug demonstrated its efficacy against COVID-19 which comes as a second line of drug [5].…”

“…Numerous researchers across the world are working on finding the cure and chemoprophylaxis of this disease with many of them are even putting their efforts to develop the vaccine. Recently some of the reports on Hydroxychloroquine [2, 3 and 4], Ivermectin [5] and Azithromycin [6], have shown therapeutic effects against novel coronavirus infection. However, it was not reported that which drug has better efficacy in comparison to other or a combination of them can give life saving results.…”