The Fear of β-Blocker Therapy in Heart Failure

Insufficient reduction in heart rate during hospitalization despite beta‐blocker treatment in acute decompensated heart failure: insights from the ASCEND‐HF trial

“…Beta‐blocker up‐titration should be considered when HF is well compensated. If reluctance to up‐titrate beta‐blockers is related to undesirable side effects, such as bronchospasm and hypotension, alternative treatment strategies to reduce HR (e.g. ivabradine) have shown the potential to achieve HR reduction .…”

Características da fadiga de pacientes com insuficiência cardíaca

“…The fear of beta blocker therapy in heart failure: Time to forget. 37 A terapia com beta bloqueador não foi associada com qualquer aumento significante do risco para fadiga. Embora o relato da incidência de vertigem fosse maior em grupos em uso de betabloqueador, outros sinais e sintomas, como bradicardia e hipotensão, foram apontados.…”

How should dexmedetomidine and clonidine be prescribed in the critical care setting?

“…increased incrementally to 1.5µg.kg-1.h-1 over 3 - 12 hours). We propose this overtly cautious approach and termed it “ start slow, go slow”, borrowed from the administration of beta-blockers in heart failure ( 128 ) ( Figure 3 ). No alpha-2 agonist bolus is ever administered.…”