BackgroundCardiovascular disease (CVD) risk reduction programs led by a nurse/community health worker team are effective in urban settings. This strategy has not been adequately tested in rural settings.ObjectiveA pilot study was conducted to examine the feasibility of implementing an evidence-based CVD risk reduction intervention adapted to a rural setting and evaluate the potential impact on CVD risk factors and health behaviors.MethodsA 2-group, experimental, repeated-measures design was used; participants were randomized to a standard primary care group (n = 30) or an intervention group (n = 30) where a registered nurse/community health worker team delivered self-management strategies in person, by phone, or by videoconferencing. Outcomes were measured at baseline and at 3 and 6 months. A sample of 60 participants was recruited and retained in the study.ResultsIn-person (46.3%) and telephone (42.3%) meetings were used more than the videoconferencing application (9%). Mean change at 3 months differed significantly between the intervention and control groups for CVD risk (−1.0 [95% confidence interval (CI), −3.1 to 1.1] vs +1.4 [95% CI, −0.4 to 3.3], respectively), total cholesterol (−13.2 [95% CI, −32.1 to 5.7.] vs +21.0 [95% CI, 4.1–38.1], respectively), and low-density lipoprotein (−11.5 [95% CI, −30.8 to 7.7] vs +19.6 [95% CI, 1.9–37.2], respectively). No between-group differences were seen in high-density lipoprotein, blood pressure, or triglycerides.ConclusionsParticipants receiving the nurse/community health worker–delivered intervention improved their risk CVD profiles, total cholesterol, and low-density lipoprotein levels at 3 months. A larger study to explore the intervention impact on CVD risk factor disparities experienced by rural populations is warranted.