The timing of the positive result did not show a trend. Furthermore, 2 employees tested positive at initiation of the protocol: 1 was asymptomatic and 1 with mild symptoms. Of the remaining 3 employees, 2 developed symptoms and tested positive on the second test. The last employee remained asymptomatic and tested positive on the final test in the protocol.The cycle threshold (Ct) values for the asymptomatic individuals were 37 and 38, and the Ct values were 21, 26, and 30 for the symptomatic employees (Table 1). These relatively high Ct values are consistent with reports that viral loads, as measured by Ct values, are lower >12 days after mRNA vaccination compared to nonvaccinated individuals. 7 All 5 vaccinated employees who tested positive had a domestic partner as the positive household contact. None of employees who were exposed to a positive child or nonsignificant other adult became infected. Spousal relationship has previously been shown to be a high risk for secondary infection, with a mean household secondary attack rate of spouses of 37.8% in prevaccination data. 8 In our limited sample, the rate of secondary infection in vaccinated healthcare workers when exposed to a SARS-CoV-2-positive partner was 22.7%, which represents a significant risk of infection.Although our study had a small sample size, the data demonstrate a persistent risk of acquisition of infection following exposure to a household member, particularly a partner with COVID-19. None of the vaccinated employees developed severe disease, which is encouraging but could also be due to risk profile. Further research into COVID-19 after vaccination is needed, including the likelihood of transmission by fully vaccinated, asymptomatic individuals in different settings.