The feasibility of serving liquid yoghurt supplemented with probiotic bacteria, Lactobacillus rhamnosus LB 21, and Lactococcus lactis L1A — A pilot study among old people with dementia in a residential care facility

Carlsson, Maine; Gustafson, Yngve; Håglin, Lena; Eriksson, Sture

doi:10.1007/s12603-009-0218-3

Cited by 19 publications

(7 citation statements)

References 43 publications

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“…Only four papers reporting results of studies where probiotics were administered to human subjects fulfilled the search criteria 85–88. In three of them, healthy volunteers were involved, with a randomized, placebo-controlled study design 85–87.…”

Section: Resultsmentioning

confidence: 99%

Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review

Ticinesi¹,

Tana²,

Nouvenne³

et al. 2018

CIA

169

133

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Cognitive frailty, defined as the coexistence of mild cognitive impairment symptoms and physical frailty phenotype in older persons, is increasingly considered the main geriatric condition predisposing to dementia. Recent studies have demonstrated that gut microbiota may be involved in frailty physiopathology by promoting chronic inflammation and anabolic resistance. The contribution of gut microbiota to the development of cognitive impairment and dementia is less defined, even though the concept of “gut–brain axis” has been well demonstrated for other neuropsychiatric disorders. The aim of this systematic review was to summarize the current state-of-the-art literature on the gut microbiota alterations associated with cognitive frailty, mild cognitive impairment and dementia and elucidate the effects of pre- or probiotic administration on cognitive symptom modulation in animal models of aging and human beings. We identified 47 papers with original data (31 from animal studies and 16 from human studies) suitable for inclusion according to our aims. We concluded that several observational and intervention studies performed in animal models of dementia (mainly Alzheimer’s disease) support the concept of a gut–brain regulation of cognitive symptoms. Modulation of vagal activity and bacterial synthesis of substances active on host neural metabolism, inflammation and amyloid deposition are the main mechanisms involved in this physiopathologic link. Conversely, there is a substantial lack of human data, both from observational and intervention studies, preventing to formulate any clinical recommendation on this topic. Gut microbiota modulation of cognitive function represents, however, a promising area of research for identifying novel preventive and treatment strategies against dementia.

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Section: Resultsmentioning

confidence: 99%

Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review

Ticinesi¹,

Tana²,

Nouvenne³

et al. 2018

CIA

169

133

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“…Proprietary ONS (‘Tonexis’) vs usual food I = 15 C = 14 NR AD N/A → E intake ↑ Cognitive function 15 weeks Beck 2002 Denmark [ 32 ] RCT Nursing home (risk of malnourishment). Home-made ONS vs usual food I = 8 C = 8 NR NR → Weight → E intake N/A 2 months Carlsson 2009 Sweden [ 34 ] CCT (BA) Group-living facilities for people with dementia. Drinkable yogurt 13 NR Mixed ↓ Weight → E intake → Fluid intake → Functional status 6 months Carver 1995 UK [ 36 ] RCT Psychiatric hospital/elderly ward (under-weight).…”

Section: Resultsmentioning

confidence: 99%

“…Staff time increased (by 1.7 minutes/resident/offer), as did product and staff costs ( p < 0.01). A CCT [ 34 ] on 15 people living in Swedish dementia facilities reported significant weight loss after six months drinkable probiotic yogurt (−3.9 kg, SD 3.9, range −9.2-3), but no change in energy or fluid intake.…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of interventions to directly support food and drink intake in people with dementia: systematic review and meta-analysis

et al. 2016

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Background: Eating and drinking difficulties are recognised sources of ill health in people with dementia. In the EDWINA (Eating and Drinking Well IN dementiA) systematic review we aimed to assess effectiveness of interventions to directly improve, maintain or facilitate oral food and drink intake, nutrition and hydration status, in people with cognitive impairment or dementia (across all settings, levels of care and support, types and degrees of dementia). Interventions included oral nutrition supplementation, food modification, dysphagia management, eating assistance and supporting the social element of eating and drinking. Methods: We comprehensively searched 13 databases for relevant intervention studies. The review was conducted with service user input in accordance with Cochrane Collaboration's guidelines. We duplicated assessment of inclusion, data extraction, and validity assessment, tabulating data, carrying out random effects meta-analysis and narrative synthesis. Results: Forty-three controlled interventions were included, disappointingly none were judged at low risk of bias. Oral nutritional supplementation studies suggested small positive short term but unclear long term effects on nutritional status. Food modification or dysphagia management studies were smaller and of low quality, providing little evidence of an improved nutritional status. Eating assistance studies provided inconsistent evidence, but studies with a strong social element around eating/drinking, although small and of low quality provided consistent suggestion of improvements in aspects of quality of life. There were few data to address stakeholders' questions. Conclusions: We found no definitive evidence on effectiveness, or lack of effectiveness, of specific interventions but studies were small and short term. People with cognitive impairment and their carers have to tackle eating problems despite this lack of evidence, so promising interventions are listed. The need remains for high quality trials tailored for people with cognitive impairment assessing robust outcomes. Systematic review registration: The systematic review protocol was registered (CRD42014007611) and is published, with the full MEDLINE search strategy, on Prospero [1].

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“…All of them (Pitkala et al 2007; Carlsson et al 2009; An et al 2010) involve elderly people living in nursing homes. Selection of these volunteers is justified by the higher incidence of constipation among ‘institutionalised’ elderly (Gallagher and O’Mahony 2009; Spinzi et al 2009; An et al 2010) and has the advantage of providing a highly homogeneous population with regard to nutritional habits and lifestyle, but this low variability does not reflect the situation of the free-living elderly population.…”

Section: Critical Points In the Modulation Of The Gut Microbiota In Ementioning

confidence: 99%

“…Moreover, only the study of Pitkala et al (2007) was performed on a large number of subjects ( n = 209) and reported the ability of two strains of Bifidobacterium longum and Bifidobacterium lactis to increase the frequency of bowel movements in institutionalised Finnish elderly. By comparison, the clinical trials undertaken by Carlsson et al (2009) and An et al (2010) involved 15 and 19 nursing home residents, respectively. The first was presented as a pilot study to evaluate the feasibility of a probiotic treatment on institutionalised aged people with dementia in Sweden, but the results obtained were not promising: Strains of Lactobacillus rhamnosus and Lactococcus lactis were not able to produce detectable effects on constipation.…”

Section: Critical Points In the Modulation Of The Gut Microbiota In Ementioning

confidence: 99%

Ageing of the human metaorganism: the microbial counterpart

Biagi

Candela

Fairweather‐Tait

et al. 2011

AGE

332

206

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Human beings have been recently reviewed as ‘metaorganisms’ as a result of a close symbiotic relationship with the intestinal microbiota. This assumption imposes a more holistic view of the ageing process where dynamics of the interaction between environment, intestinal microbiota and host must be taken into consideration. Age-related physiological changes in the gastrointestinal tract, as well as modification in lifestyle, nutritional behaviour, and functionality of the host immune system, inevitably affect the gut microbial ecosystem. Here we review the current knowledge of the changes occurring in the gut microbiota of old people, especially in the light of the most recent applications of the modern molecular characterisation techniques. The hypothetical involvement of the age-related gut microbiota unbalances in the inflamm-aging, and immunosenescence processes will also be discussed. Increasing evidence of the importance of the gut microbiota homeostasis for the host health has led to the consideration of medical/nutritional applications of this knowledge through the development of probiotic and prebiotic preparations specific for the aged population. The results of the few intervention trials reporting the use of pro/prebiotics in clinical conditions typical of the elderly will be critically reviewed.

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The feasibility of serving liquid yoghurt supplemented with probiotic bacteria, Lactobacillus rhamnosus LB 21, and Lactococcus lactis L1A — A pilot study among old people with dementia in a residential care facility

Cited by 19 publications

References 43 publications

Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review

Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review

Effectiveness of interventions to directly support food and drink intake in people with dementia: systematic review and meta-analysis

Ageing of the human metaorganism: the microbial counterpart

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