The feasibility of ultra-early and fast total‑body [68 Ga]Ga-FAPI-04 PET/CT scan

Chen, Ruohua; Yang, Xinlan; Yu, Xiaofeng; Zhou, Xiang; Ng, Yee Ling; Chen, Yumei; Li, Lianghua; Zhou, Yun; Jahanger, Atif; Li, Jianjun

doi:10.1007/s00259-022-06004-3

Cited by 8 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When extending the PET scan duration to match the long brain MR protocol in PET/MR, the tracer dose in PET imaging can possibly be reduced to minimize radiation exposure. We, herein, conducted a thorough analysis of scan duration and tracer dose in 18 The recent introduction of low-dose imaging on long axial field-of-view PET scanners has yielded very promising results regarding lesion detectability and image quality in many studies [44][45][46]. Besides, several PET tracers and novel strategies have also been explored to reduce the activity dose while maintaining image quality and lesion detection rate [29,30,47,48].…”

Section: Discussionmentioning

confidence: 99%

Optimizing scan duration and tracer dose in radiomic analysis for 18F-FDG PET/MR brain cancer

Zhuang,

Qiu,

et al. 2024

Preprint

View full text Add to dashboard Cite

Objectives: This study is to optimize scan duration and tracer dose in radiomic analysis for 18F-FDG PET/MR brain cancer. Methods: Seventeen patients with brain cancer underwent PET/MR scans with injection of 3.70 MBq/kg 18F-FDG. PET images were split into 5 (PETSD5), 10 (PETSD10), 15 (PETSD15), and 25 (PETSD25) min duration groups, and the injected dose for each group with 10% (PETD10%), 20% (PETD20%), 33% (PETD33%) and 50% (PETD50%) dose levels were then simulated. 93 radiomic features were extracted and ICC was calculated for each feature between groups, respectively. Results: ICC varied with the feature type, scan duration, and tracer dose. ICC for PETSD10, PETSD15, and PETSD25 in relation to PETSD5 showed an obviously decrease with the lengthen of scan duration and the reduction of tracer dose. ICC on PETD10%, PETD20%, PETD33%, and PETD50% in relation to full-dose PET gradually increased with the enlargement of tracer dose and the extending of scan duration. ICC on different combinations with respect to PETSD5 at full-dose presented similar trends in most features for PETSD10 at 50%, PETSD15 at 33%, and PETSD25 at 20%. Besides, 28 features were non-sensitive to different scan durations and/or dose levels. The intertations between features were slightly affected by different scan durations and/or dose levels, in which discrepancies were sensitive to the specific feature type. Conclusions: PETSD10 at 50% might be the clinically adaptable solution for 18F-FDG PET/MR brain cancer, showing reduced radiation burden, better compatibility and clinical feasibility. Changes in scan duration and/or tracer dose in PET should be approached with caution.

show abstract

Section: Discussionmentioning

confidence: 99%

Optimizing scan duration and tracer dose in radiomic analysis for 18F-FDG PET/MR brain cancer

Zhuang,

Qiu,

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Similarly, Chen et al. [12] indicated that 68 Ga‐FAPI‐04 TB‐PET scans conducted with and acquisition time of 30 s at 5 min post‐injection can achieve diagnostic accuracy comparable to that of conventional scans with an acquisition time of 60 min and duration of 300 s, thereby increasing patient throughput and comfort in oncologic evaluations.…”

Section: Current Clinical Applicationsmentioning

confidence: 99%

“…In 18 F‐FDG TB‐PET, this reduction can potentially decrease the internal effective dose to approximately 0.6–0.9 mSv. Further investigations have established that TB‐PET imaging using 50% of the standard dose of 68 Ga‐PSMA‐11 [16] or 68 Ga‐FAPI‐04 [17], along with shortened acquisition times of 2–5 min, provides sufficient image quality for oncologic evaluations. In the context of scanning, CT plays an integral role in localization, attenuation correction, and diagnostic processes.…”

Section: Current Clinical Applicationsmentioning

confidence: 99%

“…Owing to its high sensitivity, resolution, and complete coverage of all organs, TB‐PET not only produces superior images [2–4] with reduced radiation doses [7, 14, 16, 17, 20, 54] and scan times [5, 6, 8, 9] but also enables the transformation of PET from traditional single‐parameter imaging to multi‐parameter imaging [39, 42, 47–50, 52]. Previously impossible, TB‐PET enables the determination of radiotracer kinetics and distribution across multiple organs, which facilitates the elucidation of inter‐relationships among physiological/pathological factors influencing the distribution of specific radiotracers between organs [1, 11, 26, 41, 55].…”

Section: Current Clinical Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Current progress and future perspectives in total‐body positron emission tomography/computed tomography. Part II: Clinical applications

Chen,

Sun,

Huang

et al. 2024

iRADIOLOGY

View full text Add to dashboard Cite

Total‐body positron emission tomography (TB‐PET) has significantly advanced from initial conception to global commercial availability. The high sensitivity of TB‐PET has led to superior lesion detection, thereby expanding the range of clinical applications. TB‐PET technology offers several advantages: (a) It enables the detection of small lesions, facilitating precise cancer staging and targeted cancer formulation. (b) The technology shortens the acquisition time while maintaining the quality of diagnostic images. (c) TB‐PET allows for a reduction in the amount of administered radiotracer, which minimizes image noise, reduces the effective radiation dose to patients, and enhances staff safety. (d) The scanner supports the development of new tracers and the dynamic imaging of these tracers throughout the entire body. (e) TB‐PET accommodates delayed scanning, which has been shown to improve the detection of small and previously undetected malignant lesions by enhancing the clearance in areas of significant background activity. (f) Owing to its high‐quality images, TB‐PET is suitable for parametric imaging, which offers several advantages over conventional standardized uptake value imaging. However, TB‐PET still faces several challenges. There is a lack of consensus on the optimal dose and scan duration for clinical diagnosis using TB‐PET. Additionally, unified standards for parametric imaging via TB‐PET are yet to be established, and the full clinical significance of this technology remains under‐explored. The accompanying review (Part 1) covers TB‐PET data manipulation and analysis.

show abstract

The earliest optimal timing for total-body 68Ga-fibroblast activation protein inhibitor-04 PET scans: an evidence-based single-centre study

Zheng,

Gao,

Lin

et al. 2023

Eur Radiol

View full text Add to dashboard Cite

The feasibility of ultra-early and fast total‑body [68 Ga]Ga-FAPI-04 PET/CT scan

Cited by 8 publications

References 17 publications

Optimizing scan duration and tracer dose in radiomic analysis for 18F-FDG PET/MR brain cancer

Optimizing scan duration and tracer dose in radiomic analysis for 18F-FDG PET/MR brain cancer

Current progress and future perspectives in total‐body positron emission tomography/computed tomography. Part II: Clinical applications

The earliest optimal timing for total-body 68Ga-fibroblast activation protein inhibitor-04 PET scans: an evidence-based single-centre study

Contact Info

Product

Resources

About