The Features of Blood Immunological Parameters in Patients With Various Forms of Brucellosis

Abstract

Abstract. Results of current study have shown that acute brucellosis is characterized by increase of T-helper and cytotoxic T-lymphocytes and decrease of phagocytic activity of neutrophyls in the blood. In patients with chronic form of disease the decline of T-helper and cytotoxic T-lymphocytes together with activation of humoral immunity and increasing of B-lymphocytes and levels of immunoglobulins A and G have been observed. Thus, revealed changes indicating the formation of secondary immunodeficiency in chronic disease course. Results of the study confirmed the needs for a permanent immunological monitoring of patients with brucellosis as well as conducting a comprehensive immunological testing of patients to develop the individual scheme of corrective therapy.

Presentation of severe brucellosis in 5-year-old boy - challenges and results

“…Immunological disfunction in patients with brucellosis present a great interest and are differ in cases of acute and chronic forms. The decline of T-helper and cytotoxic T-lymphocytes together with activation of humoral immunity and increasing of B-lymphocytes, levels of immunoglobulins A and G have been described in literature reports and were revealed in our case (24). Most studies of the Ig isotype response in brucellosis concerned IgG, IgM and IgA, mostly, for differentiating between the acute and chronic stages of disease (25).…”

“…Besides these classes of Ig elevation, IgE was found to be a part of immune response and a helpful marker in post treatment monitoring and predicting a risk of relapse in both groups (26,27). Mentioned data indicate on the formation of secondary immunode ciency affecting the progress of brucellosis and evidence of necessity for immune regulation therapy (24,28).…”

Pathogenesis of brucellosis: analysis of the immunopathological concept

“…Модель (схема) двухкомпонентной регуляторно-сенсорной системы адаптации (BvrR/BvrS) у бруцелл (цит. по[34]) NK-клетках показала, что антиген приводит к активации большого количества спленоцитов (моноцит, образующийся в ретикулярной ткани селезенки), однако наиболее раннюю индукцию детектировали на EK-клетках…”