The Features of Posttraumatic Stress Disorder Development in Patients With Diabetes Mellitus 2 Type

Kohut, Anna; Чабан, Олег; Dolynskyi, Roman G.; Sandal, Olha; Bursa, Andrii I.; Bobryk, M.I.; Vertel, Anton V.

doi:10.36740/wlek202208115

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…Epidemiological studies in pediatric and adult populations show that PTSD is associated with a variety of comorbidities and doubles the risk of T2D, metabolic syndrome, and obesity [ 16 , 118 , 131 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 ]. Interestingly, a reduction in body weight may predict improvement in PTSD, and recovery from PTSD is associated with a reduced risk of T2D [ 137 , 146 , 147 ].…”

Section: Stress Ptsd and Obesity-related Morbiditiesmentioning

confidence: 99%

“…Moreover, genotypes with the same SNP manifest different phenotypes under similar circumstances, which explains the heterogeneity of PTSD subtypes [ 158 ]. Most studies suggest that PTSD is characterized by low cortisol levels, but there are also studies showing that PTSD is correlated with high cortisol levels [ 140 , 156 ].…”

Section: Stress Ptsd and Obesity-related Morbiditiesmentioning

confidence: 99%

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360-Degree Perspectives on Obesity

Cuciureanu,

Caratașu,

Gabrielian

et al. 2023

Medicina

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Alarming statistics show that the number of people affected by excessive weight has surpassed 2 billion, representing approximately 30% of the world’s population. The aim of this review is to provide a comprehensive overview of one of the most serious public health problems, considering that obesity requires an integrative approach that takes into account its complex etiology, including genetic, environmental, and lifestyle factors. Only an understanding of the connections between the many contributors to obesity and the synergy between treatment interventions can ensure satisfactory outcomes in reducing obesity. Mechanisms such as oxidative stress, chronic inflammation, and dysbiosis play a crucial role in the pathogenesis of obesity and its associated complications. Compounding factors such as the deleterious effects of stress, the novel challenge posed by the obesogenic digital (food) environment, and the stigma associated with obesity should not be overlooked. Preclinical research in animal models has been instrumental in elucidating these mechanisms, and translation into clinical practice has provided promising therapeutic options, including epigenetic approaches, pharmacotherapy, and bariatric surgery. However, more studies are necessary to discover new compounds that target key metabolic pathways, innovative ways to deliver the drugs, the optimal combinations of lifestyle interventions with allopathic treatments, and, last but not least, emerging biological markers for effective monitoring. With each passing day, the obesity crisis tightens its grip, threatening not only individual lives but also burdening healthcare systems and societies at large. It is high time we took action as we confront the urgent imperative to address this escalating global health challenge head-on.

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Section: Stress Ptsd and Obesity-related Morbiditiesmentioning

confidence: 99%

Section: Stress Ptsd and Obesity-related Morbiditiesmentioning

confidence: 99%

360-Degree Perspectives on Obesity

Cuciureanu,

Caratașu,

Gabrielian

et al. 2023

Medicina

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“…У низці публікацій доведено, що стрес є одним із потужних факторів ризику розвитку ССЗ та інших хронічних неінфекційних захворювань (НІЗ). Стрес взагалі значно підвищує ризик розвитку та прогресування як АГ, так і ЦД 2-го типу, а також атеросклерозу, дисліпідемії та ішемічної хвороби серця (ІХС) [4,5]. На жаль в Україні з 24 лютого 2022 року і дотепер триває повномасштабна війна.…”

Section: актуальність проблемиunclassified

Adjustment disorders, hypertension and type 2 diabetes: a cardiologist’s view (literature review)

Miloslavsky,

Koval

2023

Mìžnarodnij endokrinologìčnij žurnal

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The role of the stress factor and adjustment disorders among patients of a very high-risk group, namely with hypertension against the background of type 2 diabetes, was examined in the review of domestic and foreign sources of literature from the PubMed database. The authors provide data on the classification and terminology of adjustment disorders in this category of patients, and the contribution of the stress factor and activation of neurohumoral systems in their formation is considered in the historical aspect. The issue of the role of such adjustment disorders as anxiety, depression, sleep disorders, violent behavior in the family, at work is considered separately in terms of the negative course and progression of these dangerous diseases. Data are given on a number of non-modifiable and modifiable risk factors, namely genetic, haemodynamic, neurohumoral, hormonal and cardiometabolic characteristics of patients, prevalence, morbidity and mortality from complications of hypertension and type 2 diabetes in the presence of adjustment disorders; a brief description of diagnostic and preventive approaches to the correction of adjustment disorders among patients at a very high risk are described from a cardiologist’s standpoint.

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“…SIH has been found to double the rate of mortality risk (20) and that is more true in hospitalized patients (19). The development of PTSD among patients with diabetes can be further emphasised by insulin resistance, uncontrolled glycemia, dysfunction in the hypothalamic-pituitary-adrenal (HPA) axis and psychological contributions (21). PTSD and hyperglycemia can affect the patient's mental and physical health, as they are related conditions that have a bidirectional relationship.…”

Section: Introductionmentioning

confidence: 99%

Uncontrolled glycemia and PTSD in diabetic patients living in high conflict zones: A cross-sectional study

Bleibel,

Nasser,

Dorra

et al. 2024

Preprint

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BackgroundLocal conflicts such as those occurring in Palestinian camps in Lebanon have led to detrimental effects on the physical and psychological aspects of the people living in these regions. PTSD and uncontrolled glycemia are expected to be the consequences of these events.AimTo determine the impact of the Ein El Helwe events on blood glycemic levels and the possibility of developing post-traumatic stress disorders.DesignA cross-sectional questionnaire with self-administered questionnaires.MethodsParticipants were identified from the community of South Lebanon in the area surrounding, or inside, the Ein El Helwe Camp during the time of the events. The participants completed an electronic questionnaire which included sociodemographic data, diabetes condition and the DSM-IV symptoms of PTSD and its level. The Scale is a validated scale that had previously been translated to Arabic.ResultsA total of 234 participants were included in the final analysis of the study with almost 30% having uncontrolled glycemia. The mean age of the study participants was 53.49+13.09 years with more female than male participants and more living around rather than inside the camp. Glycemic control was associated with gender, educational level, living in or outside the camp and the body mass index. Multivariate analysis confirmed the impact of educational level, living area and PTSD on the glycemic control. The relationship between glycemic control and PTSD was based on some of the latter’s symptoms.ConclusionThe study highlighted the impact of conflicts and wars on the development of uncontrolled glycemia among participants living in and around Ein El Helwe Camp. Multiple factors contributed to the findings including sociodemographic, lifestyle factors and cultural aspects which should further be analysed in future studies. Additionally, glycemia levels should be monitored for more reliable findings in future studies.

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The Features of Posttraumatic Stress Disorder Development in Patients With Diabetes Mellitus 2 Type

Cited by 7 publications

References 35 publications

360-Degree Perspectives on Obesity

360-Degree Perspectives on Obesity

Adjustment disorders, hypertension and type 2 diabetes: a cardiologist’s view (literature review)

Uncontrolled glycemia and PTSD in diabetic patients living in high conflict zones: A cross-sectional study

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