The fellow eye effect of unilateral intravitreal conbercept injections in eyes with diabetic macular edema

Di, Yu; Li, Zhiqing; Ye, Junjie; Li, Lue; Li, Bing; Yu, Rongguo

doi:10.1007/s00592-020-01511-x

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…It was found that aflibercept and bevacizumab could reduce free VEGF levels in serum, and this result was consistent with that of Bakri et al (2007a, b). Our previous study also found a significant decrease in CRT, and the increased/unchanged BCVA accounted for a high proportion of untreated eyes (67%) after unilateral intravitreal injections of conbercept in bilateral (Di et al, 2020). In the present study, the results showed that conbercept could also be detected in the corresponding non-injected rabbit eyes and serum.…”

Section: Discussionsupporting

confidence: 81%

“…In patients with bilateral DME, we investigated the best corrected visual acuity (BCVA) and central retinal thickness (CRT) changed in untreated eyes after receiving the unilateral intravitreal conbercept injection. At the last visit, CRT decreased significantly in the untreated eyes and increased/unchanged BCVA accounted for a large proportion of the eyes (67%) after treatment ( Di et al, 2020 ). Nevertheless, the anti-VEGF mechanism in untreated eyes is controversial at present.…”

Section: Introductionmentioning

confidence: 99%

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A Study on the Drug Concentration in Fellow Eyes After Unilateral Intravitreal Injection of Conbercept Into New Zealand Rabbit Eyes

et al. 2021

Front. Pharmacol.

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Intravitreal injections of anti-vascular endothelial growth factor (VEGF) have become increasingly popular in the treatment of ocular diseases. However, few studies have determined the efficiency of unilateral intravitreal anti-VEGF injection in the fellow eye. Herein, we performed a study to investigate the drug concentration in fellow eyes and venous serum after unilateral intravitreal injection of conbercept into rabbit eyes. This is an experimental animal study. Thirty male New Zealand rabbits (60 eyes) were used. One eye of each rabbit was intravitreally injected with 0.5 mg of conbercept. Both eyes from six rabbits were enucleated on days 1, 3, 7, 14, and 30. Conbercept concentrations were measured in the serum, aqueous humor, and vitreous humor. We found conbercept was detected in the fellow eyes and serum of rabbits. Conbercept concentrations in the vitreous humor of the fellow eyes increased from 74.11 ng/ml on day 1 to 246.69 ng/ml on day 3 and then declined to 69.11 ng/ml after 30 days. The concentration in the aqueous humor peaked on day 1 with a concentration of 244.82 ng/ml and declined to 40.13 ng/ml after 30 days. The maximum conbercept concentrations in the aqueous humor and vitreous humor of fellow eyes were similar, which were 0.2 and 1.3% of those of the injected eye, respectively. A peak concentration of 102.49 ng/ml was achieved in the venous serum 1 day after intravitreal injection of conbercept, which was 0.08 and 0.5% of those of the maximum conbercept concentrations in the vitreous humor and aqueous humor of the injected eye, respectively, and 41.5 and 41.8% of the maximum conbercept concentrations in the vitreous humor and aqueous humor of the non-injected eye, respectively. In conclusion, after intravitreal injection of 0.5 mg of conbercept into rabbit eyes, very small amounts of conbercept were detected in the fellow non-injected eyes and venous serum.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

A Study on the Drug Concentration in Fellow Eyes After Unilateral Intravitreal Injection of Conbercept Into New Zealand Rabbit Eyes

et al. 2021

Front. Pharmacol.

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“…Under the combined action of ischemia and increased inflammatory secretions, the macular volume increases, the blood vessels in the macular area increase, and the permeability of the surrounding capillary osmotic pressure changes increases [ 6 ], which makes the protein molecules, water, and other components in the blood easily penetrate out through the vascular wall and effusion under the retina, causing retinal thickening, and the fibers in the macula are arranged in a radial pattern [ 11 ]. When the accumulated fluid reaches a certain amount, it will cause diabetic macular edema, affecting the visual recovery of patients [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Intravitreal Injection of Triamcinolone Acetonide and Conbercept for Intraocular Lens after Cataract Surgery

Tang¹,

Wang

Luo³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the effect of intravitreal injection of triamcinolone acetonide and conbercept on the efficacy and safety of diabetic macular edema (DME) after cataract intraocular lens (IOL) surgery. Methods. A total of 350 patients with cataract complicated with diabetic macular edema in our hospital from January 2017 to July 2021 were randomly divided into conbercept group and triamcinolone acetonide group. Patients in the conbercept group were given intravitreal injection of conbercept during IOL surgery, and patients in the triamcinolone acetonide group were given injection of triamcinolone acetonide during surgery. Results. Three months after treatment, the best-corrected visual acuity of the two groups was significantly higher than before, the corrected visual acuity of the conbercept group was more significant than the triamcinolone acetonide group, and the intraocular pressure of the triamcinolone acetonide group was higher than the conbercept group. The foveal thickness and macular volume were significantly reduced in both groups, and was reduced more in the conbercept group than in the triamcinolone acetonide group. The contents of VEGF, SDF-1, and IL-6 in both groups were significantly decreased, and the decrease was more significant in the conbercept group than in the triamcinolone acetonide group. The patients with elevated intraocular pressure, headache and vomiting, orbital swelling pain, eye swelling pain, and eye pain in the triamcinolone acetonide group were significantly higher than those in the conbercept group ( P < 0.05 ). Conclusions. Conbercept and triamcinolone acetonide has a good therapeutic effect on DME in pseudophakic eyes after cataract IOL surgery, which can reduce the degree of macular edema and improve the visual function. However, the therapeutic effect of injection therapy with conbercept is safe, the prognosis is better, and the complication rate is low.

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“…Interestingly, studies have shown that after monocular injection of anti-VEGF drugs, they can effectively enter the contralateral eye through the systemic circulation and play a certain role in reducing the thickness of macula and improving vision to a certain extent. [23,24] We considered that anti-VEGF drugs which have a positive effect on the contralateral eye, might also cause significant side effects on contralateral eye. Therefore, in this study, we also observed the changes of the various indexes of corneal nerve fibers in contralateral eyes after the multiple injections.…”

Section: Discussionmentioning

confidence: 99%

Effect of repeated intravitreal anti-vascular endothelial growth factor drugs on corneal nerves

Chen

Zhang

et al. 2023

Medicine

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To investigate the potential effect of repeated intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) drugs on corneal nerves. A total of 64 patients were treated with intravitreal injection of anti-VEGF drugs. There were 19 cases of neovascular age-related macular degeneration (AMD), 20 cases of diabetic macular edema (DME) and 25 cases of retinal vein occlusion (RVO). Twenty-nine cases were treated with aflibercept (2 mg/0.05 mL) whereas 35 cases were managed with ranibizumab (0.5 mg/0.05 mL). A corneal confocal microscope was used to collect images of corneal subbasal nerve plexus, and Image J was used for image analysis. The changes in corneal nerve were compared between 1 month after each injection and before injection. There were no significant differences in the density and length of corneal nerve at specific time after the surgery in comparison with baseline in patients who were given 3 intravitreal injections. There was no significant correlation between the numbers of injections and the changes of the corneal nerves. After 3rd injection, the nerve length of the DME group was markedly lower than that of AMD and RVO groups, the difference was statistically significant (P < .05). The nerve density of the DME group was not significantly different from that of AMD and RVO groups, whereas the nerve length and nerve density of the AMD and RVO groups were not statistically significant between each other also. The corneal nerve length after the 2nd and 3rd injections of Aflibercept were lower than that before surgery, the difference was statistically significant. There were no significant differences in nerve density and nerve length at each time point after Ranibizumab injection. The length and density of the corneal nerve after multiple injections in contralateral eye displayed no significant changes compared with the baseline. Repeated intravitreal anti-VEGF drug can reduce the length of corneal nerves. For patients who need repeated intravitreal injections of anti-VEGF drugs, especially in DM, attention should be paid on the changes affecting the corneal nerves. It is also needed to strengthen the local anti-inflammatory therapy to avoid infection and to use artificial tears to protect the microenvironment of the ocular surface after the surgery.

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The fellow eye effect of unilateral intravitreal conbercept injections in eyes with diabetic macular edema

Cited by 8 publications

References 23 publications

A Study on the Drug Concentration in Fellow Eyes After Unilateral Intravitreal Injection of Conbercept Into New Zealand Rabbit Eyes

A Study on the Drug Concentration in Fellow Eyes After Unilateral Intravitreal Injection of Conbercept Into New Zealand Rabbit Eyes

Efficacy and Safety of Intravitreal Injection of Triamcinolone Acetonide and Conbercept for Intraocular Lens after Cataract Surgery

Effect of repeated intravitreal anti-vascular endothelial growth factor drugs on corneal nerves

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