The Ferric Hydroxamate Uptake ReceptorFhuAand RelatedTonB‐Dependent Transporters in the Outer Membrane of Gram‐Negative Bacteria

Abstract

FUNCTIONAL CLASSchemiosmotic gradient; ABC transporter; bacteriophage infection; colicin import; siderophore -antibiotic conjugate and peptide antibiotic sensitivity; Ton B-dependent receptor; structurally related to the ferric enterobactin receptor, and Active transporter; siderophore; integral outer membrane protein; ferric hydroxamate uptake receptor, known as FhuA;(a) (b) 3D Structure The three-dimensional structure of FhuA in complex with ferricrocin. (a) FhuA in ribbon representation. The view is perpendicular to the barrel axis. The strands that comprise the front of th e barrel domain have bee n removed to provide an un obstructed view of the cork domain. (b) FlllI A as viewed from th e externa l environment along the barrel axis. In panels a and b, the bar rel domalll (residues 161 -714) and the cork domain (residues 1-160) are colored blue and ye ll ow, respectively. The ferr icrocin molecule IS shown as a bond model with carbon atoms white, oxygen atoms red, and nitrogen atoms blue. The ::rric iron atom is shown as a large red sphere. These and all the following color fi gures were prepared using MOLSCl111'T 95 ancl I1AST EII3 D. PDB code: IQFF.