The Fertility of Mice After Androgen Injection in Early Infancy

Peters, Hannah; Sørensen, Ivan Nørbaek

doi:10.1159/000178186

Cited by 4 publications

(2 citation statements)

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“…This is at variance with the reported total sterility of androgenized Swiss albino mice after pairing at the age of 3 months (Barraclough & Leathern, 1954). In order to clarify whether the reported difference in the reproductive performance of androgenized mice was due to a strain difference, a difference in the age at which the male became available to the andro¬ genized female, or other factors, a group of androgenized mice of the same strain as that used in the early mating experiment (Peters & Serensen, 1970) was placed with males at the age of 3 months. Their reproductive behaviour was tested and their reproductive organs examined.…”

Section: Introductionmentioning

confidence: 89%

Fertility and Mating Behaviour of Androgenized Mice

Peters¹,

Sørensen²

1971

Journal of Endocrinology

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Female Bagg mice injected with 1 mg testosterone propionate when 5 days old (androgenized mice) were sterile when they were mated at the age of 3 months. It was shown that the sterility was not due to a failure to ovulate but rather to aggressive behaviour towards the male which apparently prevented sexual consummation. The results of this study are compared with those of an earlier study (Peters & S\l=o/\rensen,1970) in which androgenized Bagg mice were mated immediately after weaning at the age of 1 month. These animals showed reduced fertility, but were not sterile. Fighting in this group of mice was only moderate and copulation and impregnation took place throughout maturity. The possible reasons for the different fertility and behaviour towards the male in androgenized mice that are mated at different ages are discussed. Androgenized females housed with males from the time of weaning, however, behave in a manner similar to that of mice which have been reared together: they fight rarely and then only moderately. It is thought that in androgenized mice a stimulus (probably a pheromone) activates their brain, previously programmed for aggression, when their first contact with a male is in adulthood: they do not become sensitive to the stimulus if they remain in constant contact with a male from the time they are weaned.Consequently, androgenized mice that are first mated when they are adult, fight their male mates, preventing insemination: those reared with a male accept and permit sexual contact when they are adult.

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Section: Introductionmentioning

confidence: 89%

Fertility and Mating Behaviour of Androgenized Mice

Peters¹,

Sørensen²

1971

Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

“…When administered to 30-day old male mice for 5 consecutive days, doses of 0-5 mg, 1 -0 mg and 2-0 mg/mouse resulted in highly significant decreases in the weights and sizes of the testes and seminal vesicles. (Kind, 1970(Kind, , 1971Peters & Sorensen, 1970;Eshkol, Lunenfeld & Peters, 1970). In the present study, Swiss strain female mice were injected with a single dose of 1 mg progesterone at the age of 5 days and ovarian devel¬ opment was studied in the neonatal and the juvenile periods.…”

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confidence: 99%