The Fetal Membranes and Mechanisms Underlying Their Labour-Associated and Pre-Labour Rupture During Pregnancy

McParland, Penny; Bell, Steven

doi:10.1017/s0965539504001238

Cited by 13 publications

(7 citation statements)

References 125 publications

(184 reference statements)

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“…The term and preterm women (without infection) all went into spontaneous labor and delivered vaginally. The term women all had spontaneous rupture of the fetal membranes with labor, while most of the preterm women (83%) had pre-labor rupture of membranes (PROM;McParland & Bell 2004). The duration of fetal membrane rupture was significantly less in the term group compared with the preterm group.…”

Section: Resultsmentioning

confidence: 94%

Preterm and infection-driven preterm labor: the role of peroxisome proliferator-activated receptors and retinoid X receptor

Holdsworth-Carson¹,

Permezel²,

Rice³

et al. 2009

Reproduction

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Approximately 8% of births are complicated by preterm delivery. To improve neonatal outcomes, a greater understanding of the mechanisms surrounding preterm parturition is required. Peroxisome proliferator-activated receptors (PPARs) have been implicated in the regulation of labor at term where they exhibit anti-inflammatory properties. Thus, we hypothesize that dysregulation of PPAR expression and activity may be associated with preterm labor and infection-associated preterm labor. The aim of this study was to compare the expression and activity of PPARs and the expression of retinoid X-receptor a (RXRA) in gestational tissues from term and preterm deliveries, and from infection-associated preterm deliveries. Quantitative RT-PCR, western blotting and activity ELISA were used to study expression and DNA binding profiles. Compared with term, preterm parturition was associated with an increased expression of PPAR d (PPARD; mRNA and protein), PPAR g (PPARG; protein) and RXRA (protein) in the placenta and PPARD (mRNA and protein) and RXRA (mRNA) in the choriodecidua. There was, however, no change in preterm PPAR DNA binding activity compared with term. Preterm chorioamnionitis (CAM) demonstrated protein degradation in the choriodecidua and was associated with a decline in the mRNA expression of PPAR a (PPARA) and RXRA compared with uninfected preterm cases. PPAR DNA binding activity increased in the placenta (PPARD and PPARG) and decreased in the amnion (PPARA and PPARG) in association with preterm CAM. In conclusion, idiopathic preterm deliveries were associated with an increase in PPAR:RXR expression and preterm CAM was associated with a decrease in PPAR:RXR expression and tissue-specific alterations in transcriptional activity. The reasons for such dysregulation remain to be determined; however, the data are consistent with the hypothesis that PPARs may play a role in preterm labor and infection-complicated preterm deliveries.

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Section: Resultsmentioning

confidence: 94%

Preterm and infection-driven preterm labor: the role of peroxisome proliferator-activated receptors and retinoid X receptor

Holdsworth-Carson¹,

Permezel²,

Rice³

et al. 2009

Reproduction

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“…PEMR mortalite ve morbiditesinde intrauterin enfeksiyon önemli rol oynar ve klinik olarak aflikar enfeksiyon varl›¤›nda mortalite ve morbiditenin dört kat artt›¤› bilinmektedir (3) .…”

Section: G‹r‹fiunclassified

THE ROLE OF uPAR,ST2,IL-33,IL-6 FOR THE DIAGNOSIS OF PRETERM PREMATURE RUPTURE OF MEMBRANES

Çekmez¹,

Öcal²,

Özkaya³

et al. 2013

J Turk Soc Obstet Gynecol

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“…3 Remodelling of the lower uterine segment and cervix and associated alterations in the fetal membrane morphology may make women more susceptible to ascending infection. The characteristic loss of the decidual layer and the resident macrophage population may contribute to this.…”

Section: Sirmentioning

confidence: 99%

A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study

McParland

Kenyon

Bae

et al. 2006

BJOG

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The Fetal Membranes and Mechanisms Underlying Their Labour-Associated and Pre-Labour Rupture During Pregnancy

Cited by 13 publications

References 125 publications

Preterm and infection-driven preterm labor: the role of peroxisome proliferator-activated receptors and retinoid X receptor

Preterm and infection-driven preterm labor: the role of peroxisome proliferator-activated receptors and retinoid X receptor

THE ROLE OF uPAR,ST2,IL-33,IL-6 FOR THE DIAGNOSIS OF PRETERM PREMATURE RUPTURE OF MEMBRANES

A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study

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